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Hey guys, I'm back with another video! This time, we will cover the basics of cannabinoids. We'll discuss the history, biochemistry, pharmacology and total synthesis of these highly useful natural products. Recent research is used as an example of the importance and potential of cannabinoids in medicine. https://www.instagram.com/totalsynthesis_official/ https://www.patreon.com/totalsynthesis https://www.total-synthesis.com This video does not endorse the preparation of illegal substances. No detailed steps or procedures for syntheses of illegal drugs are discussed. I hope it's clear that here we focus on fascinating aspects of science and on the potential that compounds have in improving the lives of patients. 00:00 Introduction of medical cannabinoids; Applications of cannabidiol (CBD) and tetrahydrocannabinol (THC) for treatment of epilepsy and other conditions; Introduction of legal high of liverwort 04:35 History and Isolation of THC; Discovery of the endocannabinoid system, endocannabinoid receptors (CB1 and CB2) and endocannabinoids anandamide and arachidonylglyceride; CB1 antagonists as anti-obesity drugs; Total synthesis of THC and CBD by Raphael Mechoulam at the Weizmann Institute 15:18 Can you get legally high from moss or liverwort? Summary of pharmacological results from the key paper, based on work of Professor Gertsch and co-workers at the University of Bern; Tetrad test, Prostaglandins; Implications for medicinal applications 21:32 Organic synthesis and two total syntheses of cis-perrottetine by Professor Carreira at ETH Zürich (2018) and Professor Kim at Seoul University (2008); Discussion of key steps and synthetic strategies and reaction mechanisms 28:17 Closing remarks Mechoulam interview/documentary: - The Scientist (2015): https://www.youtube.com/watch?v=fu6FhJIyTEc Liverwort paper: - Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high (Science Advances 2018, 4, 2166): http://advances.sciencemag.org/content/4/10/eaat2166 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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This is where I source my CBD oil for my clients. Bill Polyniak is your man, learn more at http://bluegrasshempoil.com/ THUMBS UP FOR MORE VIDEOS :) subscribe: http://bit.ly/BrandSubscribe Book a FREE INTRO CALL with Evan: http://evanbrand.com/free follow me; on facebook: https://facebook.com/mrevanbrand on twitter: https://twitter.com/mrevanbrand instagram: https://instagram.com/mrevanbrand Evan Brand, BCHN, CFMP, NTP, CPT bio: Evan Brand is an Author, Podcast Host and a Louisville, Kentucky-based Board-Certified Holistic Nutritionist, Certified Functional Medicine Practitioner, Nutritional Therapist, and Personal Trainer. He is passionate about healing the chronic fatigue, obesity, and depression epidemics after solving his own IBS and depression issues. He uses at-home lab testing and customized supplement programs to find and fix the root cause of a wide range of health symptoms. His Not Just Paleo Podcast has over 6 million downloads and counting. He is the author of Stress Solutions, REM Rehab and The Everything Guide to Nootropics. He offers free 15-minute functional medicine phone consultations at his site EvanBrand.com MY GEAR: Big Camera: http://amzn.to/2bbwktd Big Microphone: http://amzn.to/2b9ea1o Small Camera: http://amzn.to/2bbc8Ln Bendy Tripod: http://amzn.to/2b9e9L7 Lav Mic: http://amzn.to/2bY5Y48 Laptop: http://amzn.to/2bOaP6x Drone: http://amzn.to/2bbwJvQ Disclaimer: This video is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through my videos, blog posts, website information, I give suggestions for you and your doctor to research and provide general information for educational purposes only. The information provided in this video or site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. Not Just Paleo LLC and Evan Brand are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.

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With the number of foods available today that are now infused with CBD oil, cooking with CBD oil is becoming a popular topic. The question is, how do you cook with CBD oil and what can you make with it. Well, before you get too excited and throw away your sunflower or olive oil to make way for litres of CBD oil, best take some advice from a professional chef. We know a few, and here’s what they all said. Do not sautée or deep fry food in cannabis oil, or even other cooking oils infused with CBD oil. They reckon that when heated above 120 degrees Fahrenheit, CBD oil becomes really bitter, while it is also likely to also lose its potential health benefits. Kiss goodbye to CBD fish and chips then. Instead, they recommend you use it as a finishing oil or in a vinaigrette. When asked what sort of CBD oil you should use, they suggested full-spectrum CBD oil as this also includes terpenes, which are responsible for the distinctive smell and taste of cannabis. Have you got any mouthwatering recipes that use CBD oil? If so, let us know in the comments section below as we can’t find any recipes in Delia Smith’s cookery books! If you enjoyed this video make sure to Like & Subscribe!

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https://www.twitch.tv/cliptis https://discord.gg/cliptonianlegion Planner: https://mobalytics.gg/diablo-4/profile/7de9d7c7-ff76-4e9f-b646-6bcfbec2ecf9/builds/1bfce2c4-b8f6-4e24-91ae-2fb04091765a Join this channel: https://www.youtube.com/channel/UCTNiHLvyyV1r4-OLb8xaL5g/join https://linktr.ee/Cliptis #diablopartner Lazy Lighthouse Planner: https://mobalytics.gg/diablo-4/profile/7de9d7c7-ff76-4e9f-b646-6bcfbec2ecf9/builds/1bfce2c4-b8f6-4e24-91ae-2fb04091765a Check out my website: https://www.Cliptis.com Welcome to the Ultimate Farming Machine. The BMWhirlwind. This build only uses two skills in order to make it the most laid back, but strong farming build out there. Whether you're a seasoned veteran or just gearing up for Season 9, this is everything you need to know to hit the ground running. 👉 Drop your thoughts and builds in the comments—I’d love to hear what you’re planning! Get the best CBD and THC gummies here and save 25% off your first purchase with promo code WELCOME 25! https://sundayscaries.com/?snowball=cliptis Masterworking Guide: https://youtu.be/Im9PIaWGTTM?si=OVTyqP-CUC8G6q6t Don't get Oneshot Guide: https://youtu.be/5IrPJ-H_uLI?si=RijFV_haTy-xtcCS Masters of Sanctuary: https://youtube.com/playlist?list=PL92EvHNN4wYBDuvJKzxextZTR45QNKNgw&si=h1IhrGZp28iOIMC8 Need an energy boost for a long intense gaming session? Check out Rogue Energy! Use the link here https://rogueenergy.com/fnfpuzpv with code Cliptis at checkout to save 20% on your purchase. Season 8 Notes: https://docs.google.com/spreadsheets/d/1bU2uQyxAWjO6Uc0URk_A4dXfuyyEs2FDdoziaxF5ynY/edit?gid=687161748#gid=687161748 #twitch #gaming #viral #youtube #blizzard #streamer #diablo4 #diablo4classes #season8 #vesselofhatred #diabloivgameplay #diablopartner #cliptis #mastersofsanctuary

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#gummyrun #dualisticunity #nycmarathon #weededibles My podcast (Dualistic Unity) can be watched on this account, or wherever you listen to podcasts! I recommend starting with S.1 Ep.1 titled "Scratching the Surface" and going from there... Links to episode 1 on all platforms: https://dualisticunity.podbean.com/e/scratching-the-surface/ And now a little background on this video: This is my full experience taking 60mg of THC (6 x 10mg THC edibles) and running over 13 miles around New York City! This was my 6th "gummy run" video, but first on YouTube. You can find episodes 1 - 5 on my tiktok in the "Runs" playlist on my account @notandrewmurnane (linked here: https://www.tiktok.com/@notandrewmurnane?is_from_webapp=1&sender_device=pc) or just scroll through my instagram, which is also @notandrewmurnane. I started doing the gummy runs because I decided to run the NYC Marathon this year (which is tomorrow 11/5/23 and I hope to see you there!), had to raise $3,500 for the team I was on, and figured they would be a fun way to incorporate running into my content/help me raise the money. I had heard about the benefits of utilizing cannabis for workouts, but had a friend (Timm Chiusano) tell me about incorporating them into runs both to help make the experience a little more intense in certain ways, but very fun in others. For each episode I decided to take the dose of the episode number and I've honestly learned a lot about myself and how much I can actually handle through the episodes. As you probably noticed in this video, some experiences aren't necessarily super comfortable... but that doesn't mean they're bad! I used to completely avoid any amount on edibles because of a few really tough edible experiences when I was younger. I went through the same sort of feelings back then I was just way quicker to resist and fight them as opposed to let go of my opinion of how I thought I should be feeling and just accept what I was feeling. All that said, these episodes were also a sort of experiment and a way for me to figure out the best dose for runs to actually enhance the experience rather than make it more difficult. I would say my sweet spot for runs is 5 - 15mg of THC and if you can find one with some CBD and CBG, even better! I can only speak from my experience, but 5 - 15mg helps make the run more fun (especially with music) and your body feel a bit better (sometimes almost feels like you're floating as opposed to pounding the ground). This is def not advice, but if you would like to try it I would say a low dose like 3 - 5mg is great for just about anyone. Once you get above 20mg it can start getting far more mentally intense (again, just in my experience, and I'm certainly no doctor). Hope you enjoyed and feel free to subscribe so you don't miss future podcast episodes and videos like this!

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CBD(カンナビジオール)を配合した女性のウーマンバランスを考えたロールオンアロマ。簡単に持ち運べて、いつでも手軽にリラックスタイム・ストレスケアをすることができます。アロマの香りはwithmoonの人気フレーバー生理前イメージの香り「Before」の香り。毎日を忙しく過ごす方へ、アロマの香りも楽しみながらぜひCBDを日常に取り入れて頂けたらと思います。 ●商品詳細はこちら https://ashitarunrun.com/Form/Product/ProductDetail.aspx?shop=0&pid=ZZ4580481663469 #CBD #ロールオンアロマ #チル #cbd

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