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In this episode, I discuss cannabis (aka marijuana), including the biological mechanisms underlying its effects on the mind and body, its known medical applications, its impact on libido, creativity, hunger, hormones and more. I also cover the known adverse health consequences of chronic and even acute (one-time) use and the factors that determine if cannabis is helpful or harmful. Additionally, I detail how the various strains of cannabis: sativa, indica and hybrid strains, can produce such divergent effects depending on the strain type, THC-to-CBD ratio, total dosage, and frequency of use. I review why cannabis can impact speech patterns and one’s propensity to develop anxiety/depression during and after use and, in some individuals, paranoia. As the legal landscape for cannabis is rapidly evolving, this episode should interest a wide audience, including former/current cannabis users, those in the medical, sports, law enforcement, and educational communities and, of course, children, teenagers, and parents. #HubermanLab #Science #Health Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Levels: https://levels.link/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://www.insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Huberman Lab Premium https://hubermanlab.com/premium Social & Website Instagram: https://www.instagram.com/hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network Articles Inspired by Mary Jane? Mechanisms underlying enhanced creativity in cannabis users: https://bit.ly/3UWZzqT Adults with a history of recreational cannabis use have altered speech production: https://bit.ly/3RDBeDS Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study: https://bit.ly/3y9EcZR Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning: https://go.nature.com/3CrNToT Association of cannabis potency with mental ill health and addiction: a systematic review: https://bit.ly/3ycIwrg Other Links and Resources NSDR Protocol with Dr. Huberman on YouTube: https://youtu.be/AKGrmY8OSHM Timestamps 00:00:00 Cannabis (Marijuana) 00:04:46 New Huberman Lab Premium Membership 00:07:03 Tool: Non-Sleep Deep Rest (NSDR), Sleep & Anxiety 00:10:08 Levels, Thesis, InsideTracker 00:14:01 Momentous Supplements 00:15:08 Cannabis Strains, Psychoactive Compounds: THC & CBD 00:19:34 Sativa vs. Indica, Stimulant vs. Relaxation Effects 00:25:55 Hybrid Cannabis Strains, Type 1, 2 & 3 Strains 00:30:41 AG1 (Athletic Greens) 00:31:56 Naturally Occurring Receptors: Nicotinic & Cannabinoid Receptors (CB1) 00:40:35 THC, CBD vs. Endogenous Cannabinoids, Dependence 00:43:14 Endogenous Cannabinoids, Cannabinoid Receptors & Nervous System Function 00:53:07 Biological Effects of Cannabis 00:56:29 Cannabis Sativa & Subjective Effects: Mood, Stress, Alertness, Paranoia 01:04:58 Cannabis Indica & Subjective Effects, Memory, Dosage 01:09:41 Brain Areas Affected by THC & CBD, Side Effects 01:16:08 Creativity: Convergent vs. Divergent Thinking & Dopamine 01:26:41 Does Cannabis Increase Creativity? 01:35:08 Chronic Cannabis Use & Changes in Speech Patterns 01:46:46 Cannabis & Libido, Dopamine & Prolactin 01:56:55 Cannabis & Hormones: Prolactin, Testosterone, Estrogen & Fertility 02:06:53 Smoking/Vaping Tobacco or Cannabis & Negative Health Consequences 02:10:06 Avoiding Cannabis During Pregnancy/Breastfeeding, Fetal Neural Development 02:18:13 Negative Health Consequences of Cannabis, Anxiety & Depression, Tolerance 02:25:57 Cannabis Use & Adolescence/Young Adulthood, Predisposition to Psychosis 02:34:36 Adolescent Cannabis Use: Brain Development & Mental Health Disorders 02:41:44 Cannabis & Pain Management, Divergent Effects of Cannabis 02:44:54 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Premium Channel, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook, LinkedIn Disclaimer: https://hubermanlab.com/disclaimer Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

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The legality of cannabis for medical and recreational use varies by country, in terms of its possession, distribution, and cultivation, and (in regards to medical) how it can be consumed and what medical conditions it can be used for. These policies in most countries are regulated by three United Nations treaties: the 1961 Single Convention on Narcotic Drugs, the 1971 Convention on Psychotropic Substances, and the 1988 Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances. Cannabis was reclassified in 2020 to a Schedule I-only drug under the Single Convention treaty (from being a Schedule I and IV drug previously), with the schedules from strictest to least being IV, I, II, and III. As a Schedule I drug under the treaty, countries can allow the medical use of cannabis but it is considered to be an addictive drug with a serious risk of abuse. The use of cannabis for recreational purposes is prohibited in most countries; however, many have adopted a policy of decriminalization to make simple possession a non-criminal offense (often similar to a minor traffic violation). Others have much more severe penalties such as some Middle Eastern and Far Eastern countries where possession of even small amounts is punished by imprisonment for several years. Countries that have legalized recreational use of cannabis are Canada, Georgia, Germany, Luxembourg, Malta, Mexico, South Africa, Thailand, and Uruguay, plus 24 states, 3 territories, and the District of Columbia in the United States and the Australian Capital Territory in Australia. Commercial sale of recreational cannabis is legalized nationwide in three countries (Canada, Thailand, and Uruguay) and in all subnational U.S. jurisdictions that have legalized possession except Virginia and Washington, D.C. A policy of limited enforcement has also been adopted in many countries, in particular the Netherlands where the sale of cannabis is tolerated at licensed coffeeshops. Countries that have legalized medical use of cannabis include Albania, Argentina, Australia, Barbados, Brazil, Canada, Chile, Colombia, Costa Rica, Croatia, Cyprus, Czech Republic, Denmark, Ecuador, Finland, Georgia, Germany, Greece, Ireland, Israel, Italy, Jamaica, Lebanon, Luxembourg, Malawi, Malta, Mexico, the Netherlands, New Zealand, North Macedonia, Norway, Panama, Peru, Poland, Portugal, Rwanda, Saint Vincent and the Grenadines, San Marino, South Africa, Spain, Sri Lanka, Switzerland, Thailand, Ukraine, the United Kingdom, Uruguay, Vanuatu, Zambia, and Zimbabwe. Others have more restrictive laws that allow only the use of certain cannabis-derived pharmaceuticals, such as Sativex, Marinol, or Epidiolex.[8] In the United States, 38 states, 4 territories, and the District of Columbia have legalized the medical use of cannabis, but at the federal level its use remains prohibited. Easy Jam by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/

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