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Carlat Psychiatry News | Stimulant Fraud • Oral Ketamine • E-Cigarettes • Benzo Tapering • CBD 💡Subscribe to our newsletter: https://www.thecarlatreport.com/products ➡️Check out our website: https://www.thecarlatreport.com/ ================ Follow Carlat: 🔴SUBSCRIBE ► / @thecarlatreport ➡️Twitter: / CarlatPsych ================ References: Hines, Lindsey A et al. “Incident psychotic experiences following self-reported use of high- potency cannabis: Results from a longitudinal cohort study.” Addiction (Abingdon, England) vol. 119,9 (2024): 1629-1634. doi:10.1111/add.16517 Fucito, Lisa M et al. “Varenicline for E-Cigarette Cessation in Adults: A Preliminary Placebo- Controlled Randomized Trial.” American journal of preventive medicine vol. 67,2 (2024): 296- 298. doi:10.1016/j.amepre.2024.04.007 Glue, Paul et al. “Extended-release ketamine tablets for treatment-resistant depression: a randomized placebo-controlled phase 2 trial.” Nature medicine vol. 30,7 (2024): 2004-2009. doi:10.1038/s41591-024-03063-x Gundugurti, Prasad Rao et al. “Evaluation of the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol oral solution (150 mg/mL) versus placebo in mild to moderate anxiety subjects: A double blind multicenter randomized clinical trial.” Asian journal of psychiatry vol. 97 (2024): 104073. doi:10.1016/j.ajp.2024.104073 Rohde, Christopher et al. “A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression.” The American journal of psychiatry vol. 181,7 (2024): 630-638. doi:10.1176/appi.ajp.20230477 Tuisku, Anna et al. “Electronic Cigarettes vs Varenicline for Smoking Cessation in Adults: A Randomized Clinical Trial.” JAMA internal medicine vol. 184,8 (2024): 915-921. doi:10.1001/jamainternmed.2024.1822 Benzodiazapene Tapering Guidelines: https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/guidelines/bzd-cpg-narrative-draft-for-public-comment.pdf?sfvrsn=6d96408_2 ================ 0:00 - Intro 0:29 DOJ Charges Telehealth Executives 1:55 Oral Extended Release Ketamine 3:29 MDMA Trials Suspended 04:43 Liquid Clonidine and Liquid Lithium 5:46 Benzodiazepine Tapering Guidelines 8:01 Antidepressants in Bipolar Disorder 10:52 Vaping Trials and Smoking Cessation 12:54 Brexpiprazole & Sertraline For PTSD 14:15 CBD Oil for Anxiety #MentalHealthNews #psychiatry #psychiatricmedications #psychnews #psychiatrynews #psychopharmacology #pmhnp #psychnp ================ In this episode, we explore nine groundbreaking stories in mental health and psychiatric medicine, covering everything from healthcare fraud to the latest advancements in drug trials. Healthcare Fraud Charges: The US DOJ has charged executives at Done, a California telehealth company, for allegedly prescribing 40 million Adderall pills without proper evaluation. Extended Release Oral Ketamine: New trials on an extended release oral ketamine show potential for treatment-resistant depression. (https://pubmed.ncbi.nlm.nih.gov/38914860/) MDMA-assisted Psychotherapy Setbacks: After FDA approval was pulled due to ethical concerns, can upcoming trials revive this promising therapy for PTSD? Liquid Formulations: Onyda is brand name for the new liquid Clonidine XR and the return of liquid lithium citrate offer new options for ADHD and bipolar patients. Benzodiazepine Tapering Guidelines: The American Society of Addiction Medicine's new draft guidelinesadvocate for a careful, patient-centric approach, especially for vulnerable populations. Antidepressants and Bipolar Disorder: A Danish study provides some reassurance about using antidepressants in bipolar disorder, but its methodology leaves some questions unanswered. E-Cigarettes vs. Chantix: A new trial finds nicotine e-cigarettes as effective as Chantix for smoking cessation, but flavored vape products and their health risks continue to spark debate. Brexpiprazole and Sertraline for PTSD: Brexpiprazole showing promise as an add-on treatment to sertraline, but will the FDA approve this new therapy? CBD Oil for Anxiety: A new phase 3 trial offers hope for treating anxiety with CBD oil, though its high cost rmay emain a barrier for many patients.

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Are you struggling to get a good night’s sleep? Do you find yourself tossing and turning, unable to quiet your mind and drift off into a peaceful slumber? If so, you’re not alone. Many people experience difficulty sleeping, whether it’s due to stress, anxiety, or other factors. Fortunately, there are natural remedies that can help promote relaxation and improve sleep quality.

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Nightly Bliss is a unique blend of CBD and melatonin in the form of delicious gummies. CBD, or cannabidiol, is a compound found in the hemp plant that has been shown to have various health benefits, including promoting relaxation and reducing anxiety. Melatonin is a hormone that regulates sleep-wake cycles and can help signal to the body that it’s time to sleep.

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When you consume a Nightly Bliss gummy, the CBD and melatonin work together to help calm your mind and body, preparing you for a peaceful night’s sleep. CBD interacts with the body’s endocannabinoid system, which plays a role in regulating various functions, including sleep, mood, and stress response.

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Melatonin, on the other hand, signals to the body that it’s time to sleep by increasing levels of this hormone in the blood. By combining these two natural ingredients, Nightly Bliss can help reset your sleep-wake cycle, reduce the time it takes to fall asleep, and improve overall sleep quality.

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There are numerous benefits to incorporating Nightly Bliss into your nightly routine. Not only can it help improve your sleep quality, but it can also reduce feelings of stress and anxiety that may be keeping you awake at night. CBD has been shown to have calming and relaxing effects, making it a natural choice for those looking to unwind before bed.

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It is advisable to consult with your healthcare provider before taking any new supplement, especially if you are pregnant, nursing, or have a medical condition.

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