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THC and THCa Cannabinoids Professor DeBacco Research Article Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects. British journal of pharmacology, 163(7), 1344-1364. https://www.researchgate.net/publication/51485891_Taming_THC_Potential_cannabis_synergy_and_phytocannabinoid-terpenoid_entourage_effects The Famous One… THCA or tetrahydrocannabinolic acid is one of the most recognized cannabinoid ever to be discovered. While there are multiple compounds in cannabis that offer medicinal effects, and many more that modulate the impact of THC, there are none with such a psychoactive impact as THC. THC Effect The effect of consuming decarboxylated THCA, or THC, in high doses can cause near hallucinations for some. Although the effect is not technically “intoxicating,” it is certainly inebriating and often very psychedelic. The Molecule That Started the War It is this cannabinoid that is the target of the now fading drug war, which characterized cannabis as a dangerous and addictive drug. In the absence of THCA, there may never have been a war against cannabis. Original Source is CBGA THCA, like CBDA, is synthesized from CBGA in the apoplastic space of the secretory vesicle in the trichome. The enzyme that does the work is THCAS or THCA synthase. Again, there is a peroxide byproduct which is toxic to the cell, and therefore THCAS biosynthesis must occur in the trichome secretory vessel. THC and Regulations Current regulations require that all CBD hemp flowers with a THC content greater than 0.3% are thereby classified as “marijuana,” and must be destroyed. There are a few exceptions to the rule of THCAS producing THCA, and CBDAS producing CBDA. Biological Expectations vs Regulations Research from Oregon CBD company has shown that in vitro, CBDAS will produce one part THCA for every 20 parts CBDA. Therefore, with cannabinoid contents of hemp exceeding 20%, it may be totally unreasonable to have the THCA content requirement set to 0.3% or less, because we can biologically expect a minimum of 1% THCA for every 20% of CBDA produced by CBDAS, the required synthase for CBDA production. THC Interactions THC primarily interacts with the CB1 receptor in the endocannabinoid system. For the majority, these receptors are found on the nervous system tissues. When bound by THC, they modulate the electrochemical systems that allow us to perceive the world, presumably resulting in the psychoactive effect. THC vs Aspirin This may also explain its analgesic, muscle relaxant, and antispasmodic properties (Pacher et al., 2006). THC has been shown to have “20 times the anti-inflammatory power of aspirin and twice that of hydrocortisone” (Evans 1991, Russo 2011). Link to Lecture Slides: https://drive.google.com/file/d/1lon5qsVTq6Hwgvrtx37riCX6fRc4Yfqv/view?usp=sharing *Due to the description character limit the full work cited for "THC and THCa Cannabinoids" can be viewed at... https://drive.google.com/file/d/1sHnZpOj_WtjS1bkmNuMQpxnXca9DzCL3/view?usp=sharing

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CBG (Cannabigerol) Health Benefits: Nootropic, Inflammation, Mood, Anxiety & Energy (2020) ✅ BUY CBG HERE: https://www.ergogenic.health/product/cbg-extract-isolate ✅ GET MY NEW SUPPLEMENT HERE: https://bit.ly/inb4catuaba 💪🏽 GET MY TESTOSTERONE PROTOCOL HERE: https://trtfree.com 🌎 My Website (Buy World-Class Health Products Here): https://www.ergogenic.health/ 📩 Get My Most Cutting-Edge Men’s Health Hacks Delivered Straight To Your Inbox: https://go.boostyourbiology.com/newslettersignup 📲 My Instagram: https://www.instagram.com/ergogenic_health/ 🧬GET ANY BLOOD TEST WITHOUT A DOCTOR: https://marekhealth.com/ergogenic CBG can act as a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist, which may lead reduced anxiety, and possibly a reduction in anhedonia/PSSD, since 5-HT1A receptors play a key role in this condition (5). CBG may increase natural levels of anandamide (also known as the “bliss molecule”) in the brain, thereby offering anxiety relief (6). CBG may have a neuroprotective effect by protecting against cognitive decline. This may be true for people dealing with serious neurological conditions such as Huntington’s disease. These same properties may also prove helpful for people with Parkinson’s or Alzheimer’s disease (6). CBG may have anti-tumor effects. A few animal studies have suggested that CBG may slow the progression of certain cancers, including breast, colon, and prostate cancers. Additionally, CBG may stimulate appetite, thereby helping to counteract one of the effects of chemotherapy (7) Longevity CBG may offer pain relief. CBG may have pain-relieving properties. This is true for other cannabinoids including CBD and THC, but there’s some evidence that CBG may have even more pain-relieving properties than THC (1). CBG may function as a natural muscle relaxant. CBG may also help relax muscles. For this reason, CBG may be useful for the management of sports injuries or chronic pain (1). CBG may have antibacterial, antifungal, and antimicrobial properties (2) CBG may help strengthen bones. It plays a role in stimulating bone marrow growth. While more research is needed, this suggests CBG might be able to assist in the healing of bone fractures and possibly protect against osteoporosis (3). CBG may soothe inflammatory bowel disease, by reducing inflammation in the lower bowel. Meanwhile, a 2018 study found that cannabinoids in general may help turn off the body’s inflammatory response in the gut (4). DISCLAIMER: DISCLAIMER: The information provided in this video is for entertainment purposes only and IS NOT MEDICAL ADVICE. If you have questions about your health contact a medical professional.This content is strictly the opinion of Lucas Aoun and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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