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CBG and CBGa Cannabinoids Professor DeBacco Research Article Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects. British journal of pharmacology, 163(7), 1344-1364. https://www.researchgate.net/publication/51485891_Taming_THC_Potential_cannabis_synergy_and_phytocannabinoid-terpenoid_entourage_effects CBGA Pathway CBGA is produced from GPP and OA by the synthase “Aromatic Prenyltransferase” or AP. This biochemistry takes place in the plastid, which is also where the MEP pathway produces GPP and terpenes. GPP is a shared substrate for both cannabinoids and terpenes. After CBGA is synthesized, it is transported out of the plastid in a “hyaline” glob (Mahlberg), into the apoplast (Gulck). This is where the conversion of CBGA to subsequent cannabinoids takes place. If CBGA is not converted into a subsequent cannabinoid, it will accumulate in the trichome. Heat may cause it to convert to its neutral, active form, CBG. Interaction with Cannabinoid Receptors CBGA and CBG have been shown to interact with cannabinoid receptors that bind CBD and THC, modulating their effect. Anecdotal Reports Many anecdotal reports have shown that CBG has similar effects to CBD. Medical studies have shown that CBG is a “potent adrenoceptor agonist,” (Cascio et al 2010) and other studies have shown that CBG has antibiotic properties (Appendino et al 2008). It is worth noting that all of the general side-chain cannabinoids have been shown to exhibit potent antimicrobial properties. Cannabinoid Biosynthesis CBGA is the cannabinoid precursor The biosynthesis pathway leads through (or can be restricted by) CBGA Link to Lecture Slides: https://drive.google.com/file/d/1txUxTJ9Ho6Z3R4jH5jOYUHjQuzwO2GSm/view?usp=sharing *Due to the description character limit the full work cited for "CBG and CBGa Cannabinoids" can be viewed at... https://drive.google.com/file/d/1wi6esQPT0U7bIZdU5zoJqSstbUTmMCwe/view?usp=sharing

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Welcome Back To Sour Crowns! We’re in Charlotte, recording at Rey Recordings with Rizzy Rey, and we’ve got a special guest, Dapa Don, joining us. This episode features an exclusive review of Delta-8 THC Gummies. Expect honest opinions, good vibes. Check out Dapa Don!!:    instagram.com/dapadonmusic_ Rey Recordings:    instagram.com/reyrecordings Different Viewss:     instagram.com/different_viewss_

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We all know Mike Tyson. Boxing’s former World Heavyweight Champion has been in movies, professional wrestling, and even cartoons. But perhaps more surprising than even his recent announcement about coming out of retirement, is his latest business venture. A recent article in Forbes states that Tyson’s The Ranch Companies has acquired a global license in partnering with Smart Cups for the production of cannabis products. Smart Cups is kind of like those tablets of Easter Egg dye – you know, you drop them in the water/vinegar mix and they dissolve to give you a cup of red, green, blue or purple dye. The difference is that the tablets created by Smart Cups’ proprietary micro-encapsulation printing technology can be used to generate everything from energy drinks to liquid medications by simply adding water. The company’s machines allow for printing active and flavor ingredients from natural products onto the surface of the substrates or capsules. These products are then embedded in the bottom of a biodegradable plastic cup, taking liquid form when water is added. The result for beverage makers is huge savings from reduced packaging, storage and transportation costs. For Tyson and The Ranch Companies, they’ll use the Smart Cup tech to create ingestible cannabis products containing more accurate and consistent amounts of CBD. Their Smart Cups will release the ingredients when they come in contact with any liquid. The ability to provide accurate dosing will be a key competitive advantage for the company, as this has been one of the more challenging issues plaguing the CBD industry. Tyson and company are reportedly waiting on several CBD regulatory rulings before moving forward with any specific products.

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Curious to see our newest video showing how we extract our CBD oil using C02 extraction? Check out our recent vlog on the topic here https://youtu.be/bYt2kBIm5WI or our new documentary version of the step by step process here https://youtu.be/DC7SLoz43_M Would you prefer to make your own cannabis extract at home? At Endoca, we'll show you how to make Cannabis oil/CBD oil at home, EASILY! At Endoca, we produce the highest quality CBD oil and Cannabinoid extracts, using state of the art lab and GMP procedure to create a true medicine that is helping thousands of people all around the world. In this video, however, we step out from the lab and we explain to you how to make this medical Cannabis extractor CBD oil extracts at home.This is a more refined and safe procedure than the one explained by Rick Simpson who was the first person to make Cannabis oil or RSO Oil popular in the mainstream media. If you can't buy the extract we make at endoca.com, make your own natural medicine using Cannabis. What you will need in order to make your own Cannabis oil are the following: Cannabis or hemp plant material (dried and shredded), glass bowls, plastic spoon, alcohol (over 60% pure), Sieve, coffee machine, several Coffee filters (depending on how much material you have to process), water distiller or rice cooker or pan and hot plate paperclip, cigarette lighter. Make your own Cannabis oil at home, EASILY by following few easy steps. The first step consists of putting the cannabis plant material into a bowl and covering it with cold alcohol. Next, you will need to stir for three minutes with the plastic spoon and then sieve the mixture into another bowl. Then, filter the mixture through a coffee filter and distil the liquid until 80% of the alcohol volume has gone. If you use a rice cooker or hot plate to evaporate the alcohol, it is better to do this outside. Don't forget however that the fumes are very flammable and could explode. Afterward, pour the remaining liquid into a small bowl and make sure you heat on the coffee machine hot plate for 24 hours in order to remove the remaining alcohol. The final step is to take a paperclip, dip it in the oil and try lighting it with a flame. If a spark occurs there is still alcohol left so you should place it back on the coffee machine for a few more hours. If you would like to store the oil, draw it up into a medical syringe and keep it in your fridge. Cannabis oil / CBD oil is our specialty at Endoca. We make the highest quality CBD oil and Cannabinoid extracts, using our state of the art lab, supercritical CO2 extraction process and GMP procedures to create a true medicine that is helping thousand of people all around the world. To find out more about our products, make sure you visit our website - https://www.endoca.com. --------------------------------------------------------------------------------- discount code on www.endoca.com = youtubeCBD --------------------------------------------------------------------------------- Don't forget to check us out on our social media sites: Facebook: https://www.facebook.com/endoca Google+: https://plus.google.com/+EndocaCBD Twitter: https://twitter.com/Endocacbdoil Instagram: https://www.instagram.com/endoca/

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