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This video is a brief overview of the current state of information on marijuana and its two major cannabinoids - cannabidiol (CBD) and tetrahydrocannabinol (THC) - and their potential uses in head and neck cancer treatment. Epidemiology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947141/ https://pubmed.ncbi.nlm.nih.gov/30466476/ In vitro and in vivo lab data https://www.nature.com/articles/s41598-020-77674-y https://clincancerres.aacrjournals.org/content/26/11/2693 Anxiety, depression, and fatigue in head and neck cancer patients https://pubmed.ncbi.nlm.nih.gov/18513884/ https://pubmed.ncbi.nlm.nih.gov/23239423/ https://pubmed.ncbi.nlm.nih.gov/17398020/ Marijuana as a complementary treatment https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2688527 https://pubmed.ncbi.nlm.nih.gov/27005465/ Xerostomia and salivary flow https://pubmed.ncbi.nlm.nih.gov/16946411/

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The antibacterial properties of cannabinoids primarily operate through disruption of bacterial cell membranes, leading to rapid bactericidal effects. Key mechanisms include: Membrane disruption and depolarization: Cannabidiol (CBD) and cannabigerol (CBG) target the cytoplasmic membrane of Gram-positive bacteria such as Staphylococcus aureus and MRSA. This causes membrane depolarization, increased permeability, and uptake of normally impermeable dyes, indicating loss of membrane integrity. This disruption rapidly inhibits synthesis of proteins, DNA, RNA, and peptidoglycan, effectively shutting down essential bacterial processes. Inhibition of biofilm formation: CBG inhibits the ability of bacteria to form biofilms and can eradicate preformed biofilms, which are typically resistant to antibiotics. This enhances the antibacterial effect and helps clear persistent infections. Synergistic effects with antibiotics: CBD has been shown to enhance the efficacy of certain antibiotics like bacitracin by inducing abnormalities in bacterial cell division and membrane irregularities. Additionally, cannabinoids can work synergistically with polymyxin B to target multidrug-resistant Gram-negative bacteria when their outer membrane is permeabilized. Selective activity against Gram-positive and some Gram-negative bacteria: Cannabinoids are most effective against Gram-positive bacteria due to easier access to the cytoplasmic membrane. However, cannabinoids like CBD and CBG can also act on Gram-negative bacteria with permeabilized outer membranes, including drug-resistant strains such as Neisseria gonorrhoeae. Structure-activity relationship: The antibacterial potency of cannabinoids is influenced by their chemical structure, including the monoterpene region and aromatic side chains, which affect their lipid affinity and membrane interaction. In summary, cannabinoids exert antibacterial effects mainly by disrupting bacterial membranes, inhibiting biofilm formation, and enhancing antibiotic activity, making them promising candidates for new antimicrobial therapies especially against resistant Gram-positive pathogens Join this channel to get access to perks: https://www.youtube.com/channel/UC23aSgHY8WaJGw4nft7Sn7g/join

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In deze korte video gaan jullie zien hoe we een geïnfecteerde staart en vin bij een koi behandelen. De video is gemaakt op dag 4 van het totale behandelingstraject. Na 7 dagen met CBDA creme te hebben gewerkt, was de staart en vin weer compleet infectievrij. CBD is vrij bekend en komt van de cannabisplant. Het product is zo laag in THC dat er geen geestverruimende effecten zijn. Van origine zit er geen CBD in de hennepplant maar CBDA. Door het productieproces wordt CBDA omgezet in CBD. In feite verliezen we door extractie een waardevol basisbestandsdeel. Dankzij slow extraction is Holland House of Hemp er in geslaagd om CBDA te stabiliseren. Onderzoek laat zien dat het 40 tot 60 maal beter door het lichaam wordt opgenomen. Voor meer informatie neem contactop met: [email protected]

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