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CBD ist im Trend. Dutzende Influencer preisen CBD-Öl und andere Produkte als Wundermittel an, das ihr Leben leichter macht. Aber stimmen die ganzen Behauptungen? Die Science Cops denken sich: Studieren geht über Probieren. CBD-Öl soll der Gamechanger sein: Schlafstörungen, Angststörungen, Depressionen, Augeninnendruck und Tumore oder generell Schmerzen, all das soll CBD-Öl heilen oder mindern. Und bei einer derartigen Litanei an Gesundheitsversprechen haben die Quarks Science Cops, Jonathan Focke und Maximilian Doeckel, generell Fragen. Die sie aber auch ihrer Chefin Andy (Aysha Samuel) erklären müssen, denn die ist selbst fleißige Nutzerin von CBD. Aber als sie ihre Fragen stellen, schicken die Hersteller selbst den beiden einen großen Stapel Studien, welche die Wirksamkeit von CBD belegen sollen. Und tatsächlich scheint eine gewisse Wirksamkeit belegbar. Also doch alles gut? Nicht nur die Science Cops, sogar ihr Koch Ralph (Ralph Caspers) wird argwöhnisch und glaubt, die Studien der CBD-Hersteller vernebeln eine unangenehme Wahrheit. Kapitel: 00:00: Intro 01:26: CBD, das Wundermittel der Influencerinnen und Influencer 02:30: Die Versprechen von CBD 04:38: Die Wirkweise von CBD 06:35: Der Fall Charlotte Figi 08:05: Die "Studien" der Hersteller 13:04: Die Studie, bei der CBD gewinnt 15:02: Warum CBD überteuerter Unsinn ist Quellen (Auswahl, volle Liste unter https://www.quarks.de/podcast/quarks-science-cops-allheilmittel-cbd/): "CBD-Öl legal auf dem Markt? (Verbraucherzentrale 2021) https://www.verbraucherzentrale.de/wissen/lebensmittel/nahrungsergaenzungsmittel/cbdoel-legal-auf-dem-markt-37660 Cannabis: Potenzial und Risiko: Eine wissenschaftliche Bestandsaufnahme herausgegeben von Eva Hoch, Chris Maria Friemel, Miriam Schneider (Springer Medizin, 2019) https://link.springer.com/book/10.1007/978-3-662-57291-7 McPartland, J. et al.: Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review (BJP 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301686/ Di Marzo, V. et al.: Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action (National Library of Medicine 1999) https://pubmed.ncbi.nlm.nih.gov/9881850/ Blessing, E. et al.: Cannabidiol as a Potential Treatment for Anxiety Disorders (Neurotherapeutics 2015) (PDF) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/pdf/13311_2015_Article_387.pdf Mol Sci, Int: The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets (PMC 2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124847/ Suraev, A. et al.: Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) for chronic insomnia disorder (‘CANSLEEP’ trial): protocol for a randomised, placebo-controlled, double-blinded, proof-of-concept trial (BMJ 2020) https://bmjopen.bmj.com/content/10/5/e034421 Epidyolex (European Medicines Agency) https://www.ema.europa.eu/en/medicines/human/EPAR/epidyolex Graczyk, M. et al.: Prospects for the Use of Cannabinoids in Psychiatric Disorders (Front Psychiatry 2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994770/ Masataka, N.: Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders (Front Psychol. 2010) https://www.frontiersin.org/articles/10.3389/fpsyg.2019.02466/full Antonio, Z.: Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life (Front Pharmacol 2017) https://www.frontiersin.org/articles/10.3389/fphar.2017.00259/full Lopez, H.: Effects of Hemp Extract on Markers of Wellness, Stress Resilience, Recovery and Clinical Biomarkers of Safety in Overweight, But Otherwise Healthy Subjects (Journal of Dietary Supplements 2020) https://www.tandfonline.com/doi/abs/10.1080/19390211.2020.1765941?journalCode=ijds20 Shannon, S. et al.: Cannabidiol in Anxiety and Sleep: A Large Case Series (The Permanente Journal 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/?report=reader Das, R. et al.: Cannabidiol enhances consolidation of explicit fear extinction in humans (Psychopharmacology 2013) https://link.springer.com/article/10.1007/s00213-012-2955-y Medikamente auf Cannabis‐Basis zur Behandlung chronischer neuropathischer Schmerzen bei Erwachsenen – Mücke, M – 2018 (Cochrane Review 2018) https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012182.pub2/full/de Notcutt, W. et al: Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies (Association of Anaesthetists 2004) https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2044.2004.03674.x?sid=nlm%3Apubmed Ewing, L. et al: Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model (Molecules 2019) https://www.mdpi.com/1420-3049/24/9/1694 #cbd #cbdforlife #cbdöl #quarkssciencecops #sciencecops

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