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Hey guys, I'm back with another video! This time, we will cover the basics of cannabinoids. We'll discuss the history, biochemistry, pharmacology and total synthesis of these highly useful natural products. Recent research is used as an example of the importance and potential of cannabinoids in medicine. https://www.instagram.com/totalsynthesis_official/ https://www.patreon.com/totalsynthesis https://www.total-synthesis.com This video does not endorse the preparation of illegal substances. No detailed steps or procedures for syntheses of illegal drugs are discussed. I hope it's clear that here we focus on fascinating aspects of science and on the potential that compounds have in improving the lives of patients. 00:00 Introduction of medical cannabinoids; Applications of cannabidiol (CBD) and tetrahydrocannabinol (THC) for treatment of epilepsy and other conditions; Introduction of legal high of liverwort 04:35 History and Isolation of THC; Discovery of the endocannabinoid system, endocannabinoid receptors (CB1 and CB2) and endocannabinoids anandamide and arachidonylglyceride; CB1 antagonists as anti-obesity drugs; Total synthesis of THC and CBD by Raphael Mechoulam at the Weizmann Institute 15:18 Can you get legally high from moss or liverwort? Summary of pharmacological results from the key paper, based on work of Professor Gertsch and co-workers at the University of Bern; Tetrad test, Prostaglandins; Implications for medicinal applications 21:32 Organic synthesis and two total syntheses of cis-perrottetine by Professor Carreira at ETH Zürich (2018) and Professor Kim at Seoul University (2008); Discussion of key steps and synthetic strategies and reaction mechanisms 28:17 Closing remarks Mechoulam interview/documentary: - The Scientist (2015): https://www.youtube.com/watch?v=fu6FhJIyTEc Liverwort paper: - Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high (Science Advances 2018, 4, 2166): http://advances.sciencemag.org/content/4/10/eaat2166 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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Nausea can be an incredibly uncomfortable and debilitating sensation. Whether it’s caused by motion sickness, chemotherapy, pregnancy, or another reason, finding relief from nausea is a top priority for those who experience it. One common way to combat nausea is through the use of antiemetics, medications specifically designed to prevent or reduce feelings of nausea and vomiting. But how exactly do these drugs work, and what should you know before taking them?

How Antiemetics Work

Antiemetics work by targeting the various pathways in the body that can trigger the sensation of nausea. One common pathway is the chemoreceptor trigger zone (CTZ) in the brain, which is sensitive to chemical signals from the bloodstream. By blocking these signals, antiemetics can help prevent nausea from occurring.

Another pathway targeted by antiemetics is the vomiting center in the brain. This area receives signals from the CTZ, as well as from other parts of the body, that can trigger the reflex to vomit. Antiemetics can help suppress this reflex, reducing the likelihood of vomiting.

Some antiemetics also work by blocking specific neurotransmitters, such as serotonin or dopamine, that play a role in the sensation of nausea. By interfering with these neurotransmitters, antiemetics can help reduce feelings of nausea and prevent vomiting.

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Types of Antiemetics

There are several different types of antiemetics available, each targeting different pathways in the body to prevent nausea. One common type is 5-HT3 receptor antagonists, which target serotonin receptors in the gut and brain to block signals that trigger nausea and vomiting.

Another type of antiemetic is dopamine receptor antagonists, which block dopamine receptors in the brain to prevent nausea and vomiting. These medications are often used to treat chemotherapy-induced nausea and vomiting, as well as nausea associated with migraines.

Other types of antiemetics include antihistamines, which block histamine receptors in the brain, and corticosteroids, which help reduce inflammation that can contribute to nausea. Each type of antiemetic works in a slightly different way, making it important to work with your healthcare provider to find the best option for your specific needs.

Considerations Before Taking Antiemetics

Before taking antiemetics, it’s important to consider any potential side effects or interactions with other medications you may be taking. Some antiemetics can cause drowsiness, dry mouth, or constipation, so it’s essential to understand how a particular medication may affect you before using it.

Additionally, some antiemetics can interact with other medications, such as antidepressants or antibiotics, leading to potentially harmful effects. It’s crucial to discuss all medications you are taking with your healthcare provider to ensure that antiemetics are a safe option for you.

Lastly, if you are pregnant or breastfeeding, it’s especially important to consult with your healthcare provider before taking antiemetics. Some medications may not be safe for use during pregnancy or while breastfeeding, so it’s vital to discuss the risks and benefits of using antiemetics in these situations.

Conclusion

Overall, antiemetics can be a valuable tool for preventing and reducing nausea and vomiting in a variety of situations. By understanding how these medications work and considering your individual needs and circumstances, you can work with your healthcare provider to find the right antiemetic for you. If you experience frequent or severe nausea, don’t hesitate to seek medical advice to explore the best treatment options available.

In conclusion, antiemetics are a diverse group of medications that work by targeting various pathways in the body to prevent nausea and vomiting. By understanding how these medications work and considering your individual needs and circumstances, you can work with your healthcare provider to find the right antiemetic for you.