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Welcome back to The Visser Podcast! 👋 Today, I’m diving deep into Retatrutide, often called the 'triple G' agonist, and why it's poised to be a game-changer in metabolic health and longevity. We're talking about the next frontier in weight management and beyond. What is Retatrutide? This groundbreaking compound targets three crucial hormones – GLP-1, GIP, and glucagon. This unique multi-hormonal approach has shown truly remarkable results, even surpassing current leading medications like tirzepatide and semaglutide in weight loss efficacy. The Latest Clinical Insights: In its Phase 2 trials, participants saw an average of 24.2% body weight reduction (that’s about 58 lbs!) over 48 weeks. Some even experienced up to 31% loss, which is quite significant and required careful dose management. We're eagerly anticipating more data from the ongoing Phase 3 TRIUMPH program. Look out for results on obesity and OA knee studies coming in 2025, with further insights into obstructive sleep apnea (OSA) and type 2 diabetes expected by mid-2026. Plus, we'll see Phase 2b renal function trial results in Q4 2025. Safety & What We Know So Far: Like many medications in this class, common side effects include nausea and abdominal pain. The rapid weight loss observed means careful dosing is key, with some participants needing to increase caloric intake to stabilize weight. We did see one reported case of kidney stones, though its direct link to the drug is still being investigated. Beyond Weight Loss: The Broader Benefits: What truly excites me are the potential benefits beyond just weight loss. Early data suggests significant improvements in comorbidities like reduced knee pain, better cholesterol levels, and even improved fatty liver disease. There's promising data pointing to liver fat reduction and potential benefits for MASH (metabolic dysfunction-associated steatohepatitis). The Competitive Edge: Retatrutide could really solidify Eli Lilly's leadership in obesity therapeutics, potentially offering a new solution for those who haven't responded to existing therapies. It's an exciting time with new innovations like oral GLP-1 pills and once-yearly shots also in the pipeline. Key Upcoming Milestones: 2025: Phase 3 obesity/OA knee data release. 2026: Full Phase 3 results (TRIUMPH-1/-2) and potential FDA submission. 2027: Head-to-head trial vs. tirzepatide (TRIUMPH-5). This medication represents a significant step forward in our journey toward better health and longevity. I'll keep you updated as more data emerges! Let me know your thoughts and questions in the comments below! 👇 Relevant Studies & Resources: https://doi.org/10.1093/ehjcvp/pvad080 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915087 https://sciencehub.novonordisk.com/content/dam/sciencehub/global/en/congresses-and-scientific-publications/congresses/ow2024/Garvey/documents/Garvey_OASIS_4_OW24-oral_Final_23Oct24.pdf https://doi.org/10.1001/jamainternmed.2024.2525 https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-successful-phase-3-study-showing-benefit https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-retatrutide-results-published-new-england-journal https://www.boehringer-ingelheim.com/human-health/metabolic-diseases/survodutide-top-line-results-mash-fibrosis https://ir.altimmune.com/news-releases/news-release-details/correction-altimmune-presents-results-phase-2-mri-based-body https://investors.amgen.com/static-files/0176d78e-920b-45b3-b9cc-a727e58e80da https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine https://ir.vikingtherapeutics.com/2024-11-04-Viking-Therapeutics-Reports-New-Data-from-VK2735-Obesity-Program-at-ObesityWeek-R-2024 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915082 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915251 https://medically.roche.com/global/en/medical-material.3d8d7ba5-5a5d-4b7d-bed7-f4f5e05e5a6e.qr.html?cid https://www.kailera.com/press-release/jiangsu-hengrui-pharmaceuticals-and-kailera-therapeutics-report-positive-topline-data-from-8-mg-dose-of-phase-2-obesity-trial-of-glp-1-gip-receptor-dual-agonist-hrs9531/

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