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A great exercise for seniors to lose weight is to use an aerobic step. Get your heart rate up and lose weight with help from a professional personal trainer in this free video on exercising for seniors. Expert: David Dubail Contact: www.dubailfitness.com Bio: David Dubail is a professional personal trainer and the owner of Dubail Fitness Institute in Miami, Florida. Filmmaker: Paul Muller

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Oral weight loss medications include: 1. Phentermine- Increases energy and reduces appetite. Potential side effects include increased heart rate and blood pressure. Not recommended for individuals over 65 or those with a history of heart disease. Slight chance of worsening glaucoma 2. Topiramate- Suppresses appetite and improves sleep. Common side effects include dopiness and sleepiness. Should not be used on anyone with glaucoma or history of kidney stones 3. Naltrexone/Wellbutrin- Primarily reduces cravings (rather than appetite) and can improve mood. Possible side effects include nausea, vomiting, and vivid dreams. Not suitable for individuals using narcotics or those with a history of seizures. Slight chance of worsening glaucoma 4. Metformin-Helps reduce cravings for sugary and carbohydrate-rich foods, supports blood sugar regulation, and can be beneficial for individuals on antipsychotic medications. Common side effects include abdominal discomfort, diarrhea and gas. 5. Orlistat (available on amazon, approximately $60/month)- Blocks fat absorption from food. Side effects may include oily stools, floating stools, and possible staining of underwear if gas is passed. 6. Plenity (available at myplenity.com)- Expands in the stomach to promote fullness and reduce food intake. A rare but serious side effect includes the risk of obstruction in the stomach or intestines. 7. Vyvanse- Approved for the treatment of binge eating disorder. Side effects include increased heart rate and blood pressure. Not recommended for individuals over 65 or those with a history of heart disease. 8. Injectables: GLP-1 and GLP1/GIP Receptor Agonists: *coverage restricted. Reduces appetite and cravings, slows gut emptying, supports blood sugar regulation. Reduces chance of heart attack and stroke even if you do not lose weight. It takes several months to work up to an effective dose.

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Oral GLP-1 agonists—like oral semaglutide—are poised to transform the future of obesity and type 2 diabetes treatment. But how close are we to seeing these medications approved and widely available? In this video, we explore the following: How close are we to oral GLP-1s? Will we ever see ozempic and mounjaro tablets? If so, when? Will Eli Lilly, Novo Nordisk or someone else be first to market? Links: Pfizer’s press release discontinuing research on their candidate molecule: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-provides-update-oral-glp-1-receptor-agonist Eli Lilly’s April press release on Orfoglipron https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-demonstrated-statistically#:~:text=News%20Release-,Lilly's%20oral%20GLP%2D1%2C%20orforglipron%2C%20demonstrated%20statistically%20significant%20efficacy,orforglipron%20worldwide%20without%20supply%20constraints. And their follow-up press release on having these results prublished in the New England Journal of Medicine: https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-showed-compelling-efficacy-and#:~:text=Lilly's%20oral%20GLP%2D1%2C%20orforglipron,Medicine%20%7C%20Eli%20Lilly%20and%20Company NovoNordisk’s progress as of May 2025: https://www.reuters.com/sustainability/boards-policy-regulation/us-fda-accepts-novo-nordisks-application-oral-wegovy-2025-05-02/ Animal study linking *liraglutide* with thyroid cancer, suggesting it may be species-specific https://academic.oup.com/endo/article-abstract/151/4/1473/2456651?redirectedFrom=fulltext&login=false Timestamps: Timeline for getting a new drug to market [00:28] Who is developing oral GLP-1 agonists? [01:22] Eli Lilly - Orforglipron [02:22] Novo Nordisk - Rybelsus (semaglutide) and NN-9932 [04:42] What else is brewing (“The best of the rest”) [06:11] Okay, so you’ve hear a little something about ozempic, wegovy and the gang, a group of utterly revolutionary large molecules that can help aid in really significant weight loss through a series of injections helping to curb appetite and slow gastric emptying, making you feel fuller for longer, wouldn’t it be neat if this came as a tablet? Eli Lilly and Novo Nordisk think so. Eli Lilly, producer of Mounjaro and Zepbound has one drug in Phase III trials, orforglipron, with results coming out from last month and expected to keep rolling in for the rest of the year and the start of next. After which, we may see it launched as an oral medication for both diabetes and weight loss Novonordisk, already has an oral medication FDA approved but only for the management of diabetes, Rybelsus Eli Lilly have over 6,000 people enrolled in ACHIEVE phase 3 trial that is investigating orforglipron as a diabetes medicine and intend to publish the rest of the data in late 2025 and 2026. They are also running their phase 3 trials investigating its efficacy as a weight management drug under the name ATTAIN and expect to submit to the FDA and other global regulatory bodies before the end of 2025, meaning that if the trials continue to come in with positive results and the FDA are happy, Eli Lilly will be bringing an oral weight loss drug to market around the middle of 2026. as for Novo, they’ve been a lot quieter with their press releases of late Rybelsus, its an oral formulation of Novo Nordisk’s semaglutide molecule, which has proven itself effective time and time again in injection form under brands, Ozempic and Wegovy. Its already out there in the US and Europe and works, though the weight loss effects appear to be about half that of Wegovy. clinical studies have found that increasing the dose increases the weight loss achieved, with one 68-week study finding a 50mg daily oral dose led to 15% weight loss, again, linked down below. the best of the rest: On April 14, Pfizer announced the termination of the development of an attempt at an oral obesity medication after the molecule, named danuglipron, was found to damage the livers of a participant of a phase 2 trial. HRS9531, published their phase 2 trial outcomes in June 2024, finding that, in a study of 249 patients a 6.0mg INJECTION lead to an average weightloss of 16% in just 26 weeks in obese, non-diabetic participants. The phase two trial is linked down below https://diabetesjournals.org/diabetes/article/73/Supplement_1/1861-LB/155203/1861-LB-Efficacy-and-Safety-of-HRS9531-a-Novel Both Eli Lilly and Novo Nordisk are near the final hurdle, so, oral weight loss medications of the GLP-1 agonists may be arrive early 2026. ** All the information contained in this video is not intended nor implied to constitute professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general informational purposes only and does not replace a consultation with your own doctor/health professional **

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Why Semaglutide is a Game-Changer for People Struggling with Obesity Semaglutide represents a groundbreaking shift in weight loss and obesity management. Here’s why: 1. Addresses the Root Cause, Not Just Symptoms For many individuals, obesity isn’t simply a matter of willpower—it’s influenced by biology. Semaglutide works by mimicking GLP-1, a hormone that regulates appetite and blood sugar. This helps control cravings, reduce hunger, and improve how your body uses energy. 2. Sustainable Weight Loss Unlike fad diets that offer temporary results, semaglutide helps people lose significant weight and maintain it. Clinical studies show users can lose up to 15% or more of their body weight, far surpassing most diet and exercise programs alone. 3. Improves Overall Health Semaglutide isn’t just about losing weight; it’s about gaining health. By lowering blood sugar, reducing inflammation, and improving blood pressure, it tackles some of the key risks associated with obesity, like diabetes, heart disease, and joint pain. 4. Boosts Confidence and Quality of Life Shedding excess weight can enhance mobility, energy, and self-esteem. Many people find they can fully participate in life again, from chasing after kids to enjoying hobbies they once found too physically demanding. 5. A Tool, Not a Tactic Semaglutide doesn’t replace the need for healthier habits—it complements them. It provides a biological foundation that makes it easier to stick to lifestyle changes, breaking the cycle of failed diets and frustration. For those who have struggled for years with their weight, semaglutide is more than a medication—it’s hope. It’s a way to rewrite the story of their health and future.

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