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Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
NEJM : DOI: 10.1056/NEJMoa2302392
Orforglipron es un agonista oral no peptídico del receptor GLP-1 que se está desarrollando para el control del peso y el tratamiento de la diabetes tipo 2.
Orforglipron actúa como un potente agonista parcial del receptor GLP-1. GLP-1 (Péptido similar al glucagón-1) es una hormona que juega un papel en la regulación de la glucosa y el control del apetito.
Orforglipron tiene un mecanismo único de activación del receptor GLP-1. Produce señalización cAMP similar a la producida por el GLP-1 nativo. Sin embargo, conduce a una baja activación de la vía β-arrestina, que regula la internalización del receptor. Este efecto de señalización sesgada puede contribuir a su eficacia.
272 participantes fueron asignados aleatoriamente para recibir diferentes dosis de orforglipron: 12 mg, 24 mg, 36 mg, etc.
Participantes del Estudio: El estudio se centró en participantes que tenían obesidad (índice de masa corporal IMC 30) o estaban con sobrepeso (IMC entre 27 a 30) con al menos una condición relacionada con el peso, como hipertensión, dislipidemia, enfermedad cardiovascular o apnea obstructiva del sueño. Se requería que los participantes tuvieran un peso corporal estable (5% de ganancia o pérdida) durante los 3 meses anteriores a la aleatorización.
Semana 26:
Orforglipron 12 mg: -9.0 kg
Orforglipron 24 mg: -12.3 kg
Orforglipron 36 mg: -12.9 kg
Orforglipron 45 mg: -13.3 kg
Placebo: -2.1 kg
Semana 36:
Orforglipron 12 mg: -9.8 kg
Orforglipron 24 mg: -13.6 kg
Orforglipron 36 mg: -14.2 kg
Orforglipron 45 mg: -15.4 kg
Placebo: -2.4 kg
Estos valores representan el cambio medio estimado en el peso corporal desde el inicio para cada grupo. Se observó que la reducción de peso dependía de la dosis, con dosis más altas de Orforglipron resultando en una mayor pérdida de peso en comparación con el grupo placebo.
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What I Eat In A Day To Lose 100 Lbs My Weight Loss Journey
Australia is known for its stunning landscapes, laid-back lifestyle, and delicious cuisine. However, Aussies also face the same struggle as people around the world when it comes to managing their weight. With obesity rates on the rise in Australia, many individuals are looking for effective ways to shed excess pounds and improve their health.
Navigating Weight Loss Down Under with Keto Gummies AU
One popular trend that has been gaining traction in Australia is the ketogenic diet. This high-fat, low-carb eating plan has been shown to be effective for weight loss and improving overall health. Unfortunately, sticking to a strict keto diet can be challenging, especially for those with busy schedules or a sweet tooth.
That’s where Keto Gummies AU come in. These convenient and delicious gummies are specially formulated to support your keto lifestyle. Packed with essential nutrients and ingredients that promote fat burning and appetite control, Keto Gummies AU can help you stay on track with your weight loss goals while satisfying your cravings.
The Benefits of Keto Gummies AU
1. Enhanced Fat Burning: Keto Gummies AU are designed to help your body enter a state of ketosis more quickly and efficiently. This means that your body will burn fat for energy instead of carbs, helping you reach your weight loss goals faster.
2. Appetite Control: One of the biggest challenges of following a keto diet is managing hunger and cravings. Keto Gummies AU contain ingredients that help suppress appetite and reduce cravings, making it easier for you to stick to your diet plan.
3. Improved Energy Levels: Many people report feeling increased energy and mental clarity when following a ketogenic diet. Keto Gummies AU can help support your energy levels and keep you feeling alert and focused throughout the day.
How to Incorporate Keto Gummies AU into Your Weight Loss Journey
1. Start by following a ketogenic diet: In order to see the best results with Keto Gummies AU, it’s important to follow a low-carb, high-fat diet. Focus on eating plenty of healthy fats, lean proteins, and non-starchy vegetables.
2. Take Keto Gummies AU as directed: To maximize the benefits of Keto Gummies AU, make sure to take them according to the recommended dosage. This will ensure that you are getting the right amount of essential nutrients to support your weight loss goals.
3. Stay hydrated and active: Staying hydrated and incorporating regular exercise into your routine can help boost the effectiveness of Keto Gummies AU. Aim to drink plenty of water throughout the day and engage in activities that you enjoy, such as walking, cycling, or yoga.
Frequently Asked Questions about Keto Gummies AU
1. Do Keto Gummies AU have any side effects?
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No known side effects have been reported from taking Keto Gummies AU. However, it’s always a good idea to consult with a healthcare professional before starting any new dietary supplement.
2. How long does it take to see results with Keto Gummies AU?
Results may vary for each individual, but many people report seeing improvements in their weight loss journey within a few weeks of starting to take Keto Gummies AU.
3. Can I take Keto Gummies AU if I’m not following a keto diet?
While Keto Gummies AU are specifically formulated to support a ketogenic diet, they can still be beneficial for individuals looking to curb cravings and manage their weight, even if they are not following a strict keto eating plan.