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Sources and recommended reading “Grain Brain” David Perlmutter - https://amzn.to/2QJwZZ7 “Brain Maker” David Perlmutter - https://amzn.to/2QN8fit “Keto Clarity” Jimmy Moore - https://amzn.to/2QQbyW3 “Cholesterol Clarity” Jimmy Moore - https://amzn.to/2PUJobi “The Art and Science of Low Carbohydrate Performance” Jeff Volek & Stephen Phinney - https://amzn.to/2QMxfXn “Pure, White and Deadly” by John Yudkin - https://amzn.to/2PWXPf0 “Fat Chance” Robert Lustig - https://amzn.to/2MRX98P I have narrowed down my top 3 to: Green Tea or more specifically its most active ingredient EGCG , Branched Chain Amino Acids perhaps most predominately Leucine, and Medium chain triglycerides namely the 8-carbon saturated fatty acid called Caprylic Acid. Let me explain why! Green Tea I definitely wouldn't say that green tea is the most popular synergistic supplement with a ketogenic diet, but it is highly effective in its ability to reduce the tendency to absorb fat and increase the ability to burn fat. It comes down to the potent fat oxidation that green tea promotes from it being a rich source of polyphenol catechins. In particular EGCG or epigallocatechin gallate is the most active of the catechins in green tea and is primarily responsible for the antioxidant, anti inflammatory, and metabolic effects. To break this down even further the boost in fat metabolism comes from EGCG's direct effect on proteins and phospholipids in the plasma membrane that up regulate mitochondrial function, which we know is the energy factory for all cells in our body, therefore increasing the rate at which fatty acids are metabolized. Or in other words increasing our use of fat to produce energy. In a ketogenic diet where we are primarily depending on fat metabolism for energy, we can see how this boost in fat oxidation can provide improvements in ketone production and can promote further weight loss in the form of body fat or adipose tissue. In addition the naturally occurring caffeine in green tea works synergistically to boost metabolism. BCAA The branched chain amino acids consist of three essential amino acids, meaning they must be consumed and can not be manufactured inside the body, these 3 are: leucine, isoleucine, and valine. We know that in metabolism fueled by glucose protein and amino acid breakdown is inevitable which is what prompts athletes trying to build lean muscle mass to supplement BCAAs. While the ketogenic metabolism has been proven to spare these BCAAs, they also play larger rolls, making their heightened levels even more valuable. As discussed in the "ketogenic effects of muscle building" video, Leucine is able to take on the role of insulin, that is suppressed in a ketogenic diet, and effectively promote muscle protein synthesis. On a smaller cellular level these BCAAs are able to replenish the intermediates for cellular energy cycles, which is a huge benefit in a ketogenic diet were glycolysis is lowered and cellular pyruvate is not as available. In other words BCAAs are able to be broken down into important substrates for cellular energy production, which aids in overall higher energy levels. MCT's Medium Chain Triglycerides are some what of a staple of the ketogenic diet. The structure that allows MCT's to be metabolized quickly, provides pathways for ketone production even in unadapted individuals. The uses of MCTs can range from a daily ketone boost to aiding in the elimination of the tough to deal with side effects of keto adaptation. Tryglycerides in general are made up of a glycerol bound to three fatty acids, and are ingested, stored and more commonly referred to as fats. The differentiating factor between long chain and medium chain triglycerides are the length of the fatty acids that make up their structure. These shorter, medium chain fatty acids, are metabolized in the liver so readily that they are pushed to the front of the line even before simple carbohydrates, resulting in ketone production even when carbs and glucose are present. This is the mechanism that helps decrease the lack of energy and brain fog during the short keto adaptation phase. The MCT's promote ketone production before nutritional ketosis has been reached, making up for the deficit in energy due to the considerable reduction in available energy from carbohydrates when switching to a ketogenic diet. The fact that these MCTs are broken down even before carbohydrates makes them a promising supplement even for a diet regimen including carbs, as a way to reap the benefits of the small increase in ketone production without achieving nutritional ketosis. Keto Science!

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My guest is Dr. Chris Palmer, M.D., a board-certified psychiatrist and professor at Harvard Medical School. He explains how specific nutrition, exercise, supplement-based, and other factors can improve mitochondrial health and thereby provide relief from adult and childhood ADHD, bipolar disorder, schizophrenia, and symptoms of autism. We discuss mitochondrial biology, whether vaccines can impact inflammation and mitochondrial health, and the potential ramifications. We also review creatine, methylene blue, and urolithin A, as well as the role of B vitamins and iron in treating depression. By the end of this episode, you will understand the powerful link between metabolic health and mental health, and the lifestyle, dietary, and other factors you can leverage to help overcome common mental health challenges and disorders. Read the episode show notes: https://go.hubermanlab.com/HohfgwG *Thank you to our sponsors* AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman LMNT: https://drinklmnt.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman *Dr. Chris Palmer* Brain Energy (book): https://amzn.to/4j4pus2 Personal website: https://www.chrispalmermd.com Harvard academic profile: https://cmecatalog.hms.harvard.edu/faculty-staff/christopher-palmer Brain Energy Fund: https://www.gofundme.com/f/the-brain-energy-fund Newsletter Signup: https://newsletter.brainenergy.com Facebook: https://www.facebook.com/ChrisPalmerMD X: https://x.com/ChrisPalmerMD Instagram: https://www.instagram.com/chrispalmermd YouTube: https://www.youtube.com/@ChrisPalmerMD Threads: https://www.threads.net/@chrispalmermd LinkedIn: https://www.linkedin.com/in/christopher-palmer-01713032 *Timestamps* 00:00:00 Dr. Chris Palmer 00:02:15 Integrating Metabolic, Mental & Physical Health; Childhood Trauma & Risk 00:10:46 Sponsors: Our Place & LMNT 00:13:44 Depression Causes, Molecule Model?, Neuroplasticity?; Metabolism 00:22:20 Mitochondrial Functions, Stress Response, Mental Health 00:31:09 Sponsors: AG1 & Eight Sleep 00:33:59 Mitochondrial Health & 6 Pillars of Lifestyle Medicine 00:39:38 Stimulants, Mitochondria, Dopamine; Alcohol 00:45:47 Nicotine; Substance Use, Metabolic Health & Disease 00:52:23 Children, Energy & Metabolic Function; Diseases of Aging & Mental Disorders 00:59:18 Sponsor: Function 01:01:06 Diet & Metabolism; Ultra-Processed Foods, Additives, GRAS 01:09:30 Rebellious Spirit, Ultra-Processed Foods & Food Industry Funding 01:19:14 Ketogenic Diet, Epilepsy, Schizophrenia, Bipolar 01:22:52 Ketogenic Diet, Fasting & Mitochondria; Gut Microbiome, Brain Metabolism 01:30:06 Low-Fat Diets; Tool: Occasional Fasts; Ketogenic Diet; Intermittent Fasting 01:38:40 Nutrition Research, Food Industry Lobbyists; Ultra-Processed Foods, Addiction 01:46:55 Creatine & Mitochondrial Health 01:52:34 Methylene Blue & Mitochondria; Serotonin Syndrome 02:02:58 Urolithin A, Mitochondria Function; Supplements & Appropriate Use 02:11:14 Vitamin Deficiencies, Iron Deficiency 02:16:06 Vitamin B12 & Folate Deficiency, Autoimmune Disorders 02:24:48 Mental Illness & Root Causes 02:29:02 Vaccines, Inflammation, Mitochondria, Autism 02:39:17 Neurodevelopmental Disorder Onset & Follow-Up 02:45:31 Vaccines, Autism, Future Research; Mother Obesity & Diabetes 02:51:23 Father Obesity & Autism; Poor Metabolic Health, Blood Biomarkers 02:56:44 Assessing Metabolic Health & Biomarkers; National Institutes of Health (NIH) 03:02:59 Future Directions, Bridging Mental & Physical Health 03:09:27 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter #HubermanLab #Science #Health #MentalHealth #Nutrition Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

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With a fast metabolism, gaining weight is still an attainable goal with strength training and a balanced diet. Gain weight with tips from a nationally-certified personal trainer in this free video on weight loss. Expert: Jani Roberts Contact: www.janiwestroberts.com Bio: Jani Roberts is a graduate of the American Academy of Nutrition and owner of The Wellness Company of Dunedin. Roberts is a nationally certified personal trainer and group fitness instructor. Filmmaker: Christopher Rokosz

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Struggling with PCOD and weight loss? You're not alone! In this video, we break down "how to lose weight with PCOD", share tips on creating a sustainable diet plan, and bust myths around PCOD weight loss. Discover effective ways to manage PCOD symptoms, including hormonal imbalances and slow metabolism, without falling for fad diets or quick fixes. 🔥 Key Points Covered: - What NOT to do when losing weight with PCOD. - Effective tips for weight loss with PCOD. - Nutrition, workouts, and lifestyle changes that actually work. - Busting common PCOD myths. PCOD (Polycystic Ovary Syndrome) affects millions of women worldwide, leading to hormonal imbalances, weight gain, and metabolism issues. But it doesn’t have to stop you from reaching your fitness goals! Whether you’ve struggled with diets or are unsure about exercises, this video breaks down how to get results with the right guidance. PCOD may slow your weight loss progress, but with the right steps, you can transform your body and take control of your health! ➡ Want personalized guidance for your PCOD weight loss journey? _____________________________ Learn more about our PAID coaching programs: Click here - https://bit.ly/MHByt _____________________________ Join our Fitness Community: https://www.facebook.com/groups/Myhealthbuddy Our social media pages: Facebook: https://www.facebook.com/Myhealthbuddy Instagram: https://www.instagram.com/myhealthbuddy LinkedIn: https://www.linkedin.com/company/myhealthbuddy Twitter: https://twitter.com/myhealthbuddy11 Email: [email protected] #pcod #pcodweightloss #pcoddiet #pcos

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#cardiology #casereport #internalmedicine #podcast #immunology The podcast discusses a study showing that the drug semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, significantly reduces pain and weight in obese individuals with knee osteoarthritis, suggesting a potential new treatment.

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Celebrating One Year of The Downsized: Our Weight Loss Journey and Lessons Learned Join Christopher and Laraine Durham as they celebrate the one-year anniversary of their YouTube channel, The Downsized, focusing on GLP-1 weight loss medications. The couple shares their personal weight loss journeys, with Christopher losing 102 lbs and Laraine 53 lbs, since starting tirzepatide in September 2023. They reveal the reasons behind starting the channel, overcoming initial skepticism, and transitioning from skeptics to evangelists for GLP-1 drugs. The episode also explores the evolution of their channel, including the introduction of news segments and live Q&A sessions, and highlights the supportive community they've built. The Durhams express gratitude to their 11,500 subscribers, discuss plans, and invite viewers to join their upcoming cruise event, bringing together the Downsized community. The episode concludes with an invitation for viewers to share their own stories or participate in interviews for the channel. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at... DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: / @thedownsized DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Welcome to The Downsized 00:10 Celebrating One Year on YouTube 00:50 Our Weight Loss Journey 02:48 Starting the YouTube Channel 12:19 The Oprah Effect 18:38 Building a Community 27:07 Challenges and Successes 37:08 Looking Ahead

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