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Metformin is the first-line medication for type 2 diabetes in over 80 percent of global endocrinology guidelines. Evidence: International Diabetes Federation and American Diabetes Association both recommend it as first choice for new diagnoses. About 60 percent of people who take metformin experience weight loss, averaging 3.5 to 4 kilograms (around 8 pounds) per year. Evidence: Multiple meta-analyses (e.g., Diabetes Obes Metab, 2018) show this effect in both diabetics and people with prediabetes or PCOS. Metformin is linked to a lower risk of certain cancers, especially in people with diabetes. Evidence: Studies suggest a 10–40 percent reduction in risk for some cancers (like colon, breast, prostate), but evidence is mixed and not yet conclusive for non-diabetics. Metformin acts mainly by reducing glucose production in the liver (gluconeogenesis), activating the AMPK pathway. AMPK is a central energy sensor, signaling the body to burn fat and save energy. This is a well-documented, universal mechanism in all users. Metformin increases fat burning and improves insulin sensitivity, making it effective for both weight loss and improving blood sugar control. Evidence: Consistent findings in both clinical trials and real-world practice. More than 30 percent of metformin users experience mild gastrointestinal side effects (nausea, bloating, diarrhea), but only about 5 percent stop due to these effects. Evidence: Meta-analyses, e.g., in Diabetes Care, confirm these percentages. Long-term metformin use causes vitamin B12 deficiency in about 5–10 percent of users. Recommendation: Regular B12 monitoring every 2–3 years if on long-term therapy. Supplementation can fully correct the deficiency. Metformin is not recommended for people with severe kidney, liver, or heart failure due to the risk of lactic acidosis (extremely rare—much less than 1 percent if kidneys are normal). Metformin may extend lifespan in animals by about 10 percent. Evidence: Animal studies show this reliably. The TAME trial (for humans) is ongoing, with results expected in 2026. Metformin is frequently used “off-label” in people without diabetes (e.g., prediabetes, PCOS), but current guidelines do not recommend it for weight loss in healthy people due to limited long-term safety data in this group. Disclaimer: This information is provided for general knowledge and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always consult with your doctor for any questions or concerns you may have about your health.

Losing Weight With A Treadmill Desk

http://tinyurl.com/FatBurningFurnace0 Diets That Work? Forget It!... You WON'T lose weight fast and keep it off by just eating low carb diets, low fat diets, or low calorie diets. The truth is, fast weight loss that lasts comes down to a diet that works, but that is right for you. You're going to discover an easy way to trick your body into burning more calories by eating more with these delicious and healthy fat burning foods that satisfy your cravings... Cardio Doesn't Work... Those long and frequent cardio or aerobic workouts from quick weight loss programs are the WORST WAY to burn fat. You're going to see how to almost triple your fat loss and fitness results by exercising in the complete OPPOSITE manner with these tips for just 45 minutes a WEEK...with no cardio at all! You Can't Lose Belly Fat With Crunches & Sit-ups... 1000's of crunches, sit ups, or those crappy infomercial abs gizmos WILL NOT allow you to lose belly fat or give you a flatter stomach and certainly not six pack abs. You're going to learn how to lose stomach fat 5 times faster with these full body exercises that don't actually target your abs at all... Late Night Eating Is A Myth... Going to bed hungry is actually one of the WORST THINGS YOU CAN DO. You're going to discover you can boost the super powerful fat loss hormones in your body by eating the right type of tasty little dish an hour or so before you go to sleep... The 'Fat Burning Zone' Is A BIG Mistake... The "fat burning zone" you see on most cardio machines is actually the LAST THING you want to follow to burn the most body fat. You're going to burn fat and calories for up to 3 days like we do with this VERY DIFFERENT rapid and simple workout... 'Toning' Your Muscles Doesn't Work... Trying to "tone" your body by using light weights or high repetitions is a BIG WASTE OF TIME. You will experience ZERO results this way. But now you're going to lose 10 pounds, lose 20 pounds, lose 30 pounds or more...all while sculpting a leaner and sexier body that will burn your stored body fat for energy for years to come with this 1 overlooked technique http://tinyurl.com/FatBurningFurnace0

The Truth Behind Ozempic And Celebrity Weight Loss In India

Hi and welcome or welcome back! Are you ready to get lean faster without jumping on the latest fad diet or spending hours at the gym? Discover the power of five underrated habits that most people overlook but can drastically enhance your fat-loss journey. It’s not only about the big workouts or meal plans; sometimes, the smallest changes make the biggest impact. Prioritize protein at every meal to boost metabolism and keep cravings at bay. Boost your daily movement through simple walks to enhance calorie burn. Stay hydrated by drinking water before meals to help control appetite. Never underestimate the power of a good night’s sleep—aim for 7–9 hours to support recovery and hormone balance. And finally, manage stress to keep harmful cortisol levels in check and support fat loss. These habits might seem simple, but when combined, they form a powerful foundation for sustainable results. Embrace one habit at a time, stay consistent, and watch your body transform. Your leaner, healthier self is possible, one habit at a time! If you find these tips helpful, make sure to like this video and subscribe for more actionable fitness advice. Let’s embark on this journey together—one step, one meal, and one night's sleep at a time. Related Videos: https://youtube.com/shorts/tPS1cn2Gjfk?si=9Uc7RHFjN341qIqF https://youtu.be/L7AIbkxVHFU?si=cF9X9dmPZ1VReT_L Follow me on IG: https://www.instagram.com/fitness_after_50_?igsh=MW5ueWg5bDljbHlwbA%3D%3D&utm_source=qr Join our Community: https://beacons.ai/fitnessafter50 Buy Me a Coffee: https://buymeacoffee.com/fitnessafter50 Email for Business Inquiries: [email protected] Timestamps: 0:00 Intro 1:48 Walk more 2:52 Hydrate 3:57 Prioritize sleep 5:07 Manage stress 6:24 Taking action 7:05 Outro DISCLAIMER: This video is for informational and entertainment purposes only. This video and the contents within this video should not be used for medical recommendations, health advice, or treatment of any medical conditions. Please consult with your medical provider before engaging in an exercise regimen. Tags: #fatloss #fatlossmotivation #lifestyle #motivation #weightlossjourney #weightlossmotivation #weightlosstransformation #fitness #fitnesslife #fitnessmotivation #health #healthylifestyle 7

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Dr. Jodi Nishida is a Doctor of Pharmacy and accredited Metabolic Healthcare Provider who’s been in healthcare for over 28 years. After experiencing the ketogenic lifestyle’s effect on her own severe autoimmune condition, she decided to pivot her career and build a keto-based medical practice so others could benefit from it, too. She has now worked with over 3000 patients, primarily in the state of Hawaii, over the last 5 years. For 12 years of her career, she worked for Big Pharma and Biotech and has seen first hand how these companies operate to influence physician behavior. Instagram: @theketoprescription YouTube: The Keto Prescription Facebook: Jodi Nishida Website: www.theketoprescription.com Timestamps: 00:00 Trailer. 00:54 Introduction. 05:39 Asian rice consumption relates to diabetes risk. 07:21 Pharmaceutical drugs not reducing disease rates. 10:26 Keto diet led to new medical approach. 12:30 Vegetables and food options in Hawaii. 18:33 Inefficient healthcare system. 23:05 Metabolic approach to cardiovascular disease. 26:15 LDL as primary cause of heart problems. 29:26 Plaque reversal in some patients. 31:47 Ketosis helps cancer treatment with fewer side effects. 34:30 Improving patient nutrition. 38:08 Dietary identity flexibility. 41:19 Corporate medicine. 44:03 Drug testing and marketing practices. 45:23 Medication use health risks. 48:11 Where to find Jodi. See open positions at Revero: https://jobs.lever.co/Revero/ Join Carnivore Diet for a free 30 day trial: https://carnivore.diet/join/ Carnivore Shirts: https://merch.carnivore.diet Subscribe to our Newsletter: https://carnivore.diet/subscribe/ . ‪#revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation #humanfood #AnimalBased #ZeroCarb #DietCoach #FatAdapted #Carnivore #sugarfree ‪

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If you’re using a GLP-1 medication, how much protein, fiber or fat do you need to stay healthy? A review of current scientific evidence leads to nutritional recommendations from medical experts. https://www.healthday.com/healthday-tv/weight-loss/meeting-your-nutritional-needs-on-glp-1-meds-the-foods-experts-recommend If you’re using a GLP-1 medication to lose weight, how much protein, fiber or fat do you need to stay healthy? To help answer that question, a team of medical experts reviewed current scientific evidence and came up with a list of nutritional recommendations for patients. #1: Your minimum calorie intake should be personalized based on age, gender, body weight and physical activity. But in general, 1,200-1,500 calories per day for women and 1,500-1,800 per day for men is safe during GLP-1 weight loss. #2: More than 60-75 grams of protein per day can be recommended…with higher amounts considered on an individual basis. The best sources include beans, lentils, nuts, seeds, seafood, lean meat, poultry, low-fat dairy and eggs. #3: 45–65% of calories should come from healthy carbohydrates like whole grains, fruits, vegetables, nuts and dairy products. Added sugars should be limited to less than 10% of energy intake. #4: 20-35% of calories should come from fats. Good choices include nuts and seeds, avocados, vegetable oils, fatty fish and seafood. Fried and high-fat foods should be avoided. #5: Women should aim for 21-25 grams of fiber per day and men 30-38 grams per day depending on age. Supplements can be considered when patients are unable to meet these goals with foods like fruits, veggies and whole grains. #6: Drink up! 2-3 liters of fluid per day of water or low-calorie beverages such as unsweetened coffee or tea is the goal. But avoid caffeine due to its diuretic effect. Finally, focus on key micronutrients like potassium, calcium, vitamin D and vitamin B12. If you aren’t getting enough through your diet, a multivitamin and other supplements may be appropriate. Visit HealthDay.com: https://healthday.com Like HealthDay on Facebook: https://www.facebook.com/HealthDayNews Follow HealthDay on Instagram: https://www.instagram.com/healthday_news Follow HealthDay on Twitter: https://twitter.com/HealthDayTweets Connect with HealthDay on LinkedIn: https://www.linkedin.com/company/418188/

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Who Should NOT Take Semaglutide? In this informative video, we discuss important considerations regarding semaglutide, a medication that has gained popularity for weight loss and obesity management. While it may be beneficial for many, it is essential to understand that certain individuals should avoid this treatment due to potential health risks. We will cover specific groups of people who should steer clear of semaglutide, including those with particular medical histories and conditions. Understanding who should not use semaglutide is vital for ensuring safety and effectiveness. We will outline the health conditions that may lead to complications if semaglutide is taken. Additionally, we will emphasize the importance of consulting with a healthcare provider before starting any new medication, especially for those with existing health concerns. Join us as we break down the key factors to consider and help you make informed decisions about semaglutide and weight management. Don’t forget to subscribe to our channel for more helpful discussions and tips on obesity and health-related topics. ⬇️ Subscribe to our channel for more valuable insights. 🔗Subscribe: https://www.youtube.com/@ObesityFightersClub/?sub_confirmation=1 #Semaglutide #WeightLoss #ObesityManagement #HealthRisks #MedicationAwareness #ThyroidCancer #DiabeticRetinopathy #Pancreatitis #PregnancySafety #SurgeryRisks #MedicationInteractions #HealthConsultation #ChildrensHealth #Wellness #HealthyLiving About Us: Welcome to Obesity Fighters Club! Our channel is dedicated to helping you achieve your weight loss goals and embrace a healthier lifestyle. We cover a variety of topics, including effective weight loss tips, healthy eating habits, and fitness motivation tailored for all levels. Whether you're seeking fat-burning workouts or meal planning strategies for sustainable weight loss, we’ve got you covered.The content provided is for general, informational, and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay seeking it because of something you have seen in this content. Never rely on this information in place of consulting with qualified healthcare professionals. The creators and distributors of this content are not responsible for any adverse effects or consequences resulting from the use of any suggestions, preparations, or procedures described in this material. Always consult with your healthcare provider before starting any new health-related practice or program.

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Title: Obesity and GLP-1 Weight Loss Drugs: Interview with Dr. Joshua Gross Date: 7/2/25 Name of podcast: Thrivology Lab Episode title and number: #23 Obesity and GLP-1 Weight Loss Drugs: Interview with Dr. Joshua Gross Brief summary of episode: In this episode we discuss how happiness and wellbeing change over your life and examine the data supporting the midlife crisis. Bullet points of key topics + chapter markers Topic #1 [0:00] Intro. Topic #2 [7:30] The obesity pandemic and its causes Topic #3 [15:00] The evolutionary mismatch and the bliss point Topic #4 [24:00] Why is there a market for these drugs? Why not “just diet?” Topic #5 [36 :00] How do GLP-1 drugs work? Dopamine in anticipation or reward and addiction. Topic #6 [52:30] Upsides and Downsides of GLP-1 drugs Topic #7 [1:09] What is next for weight loss drugs? References & Resources: https://hhd.psu.edu/contact/joshua-gross https://rss.com/podcasts/thrivologylab/1700676/ https://rss.com/podcasts/thrivologylab/1687628/ YouTube: https://www.youtube.com/@ThrivologyLab Website: https://rss.com/podcasts/thrivologylab Email us: [email protected] Facebook: https://www.facebook.com/profile.php?id=61563253955910&mibextid=LQQJ4d Instagram: https://www.instagram.com/thrivologylab?igsh=MXB0cmhkYWM4cXB2ZQ%3D%3D&utm_source=qr