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Veronica Brady, PhD, FNP-BC of the University of Texas MD Anderson Cancer Center, joined Cancer Nursing Today to discuss her insights on the use of GLP-1 agonists in patients receiving treatment for various types of cancer. “It depends on the cancer that they’re being treated for,” Dr. Brady said. “If they are being treated for a pancreatic cancer, I do not advise use of a GLP-1. If they’re being treated for thyroid cancer, GLP-1s are contraindicated.” Although Dr. Brady did not advise the use of the medication during treatment for pancreatic or thyroid cancer, she highlighted treatment situations in which a GLP-1 could be helpful for patients. “If they are a person that is toward the end of their treatment and they have some concerns about their weight and their blood sugars are elevated, I would try a GLP-1,” she said. “Most definitely.” Dr. Brady explained that while GLP-1 agonists assist with appetite suppression to facilitate weight loss, it’s crucial that patients first adjust their diet to maximize the effectiveness of the medication. “If a person who’s willing to weigh themselves a couple times a week and track that weight loss, [a] GLP-1 in that situation may be feasible,” she said. “But if it’s somebody who is not going to pay attention, [who is] just going to take it because it’s going to decrease [their] appetite, [and] if they’re not eating well already, [then] GLP-1 is not the answer.” Dr. Brady emphasized that patients and their healthcare professionals should also consider the side effects of using a GLP-1 during cancer treatment. “Even if they’re weight-challenged, GLP-1s may not be the answer if they’re not eating well, if they’ve got nausea, [and] vomiting, that is not the drug of choice,” she explained. “So it’s a select patient group that we can use GLP-1s [for].”

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