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At the European Society for the Study of Diabetes (EASD) Annual Meeting in Barcelona, Steve Bain discusses the major challenges in developing an oral GLP-1 receptor agonist and how was this overcome with semaglutide. 1. What were the major challenges in developing an oral GLP-1 receptor agonist and how was this overcome with semaglutide? (0:05) 2. Is the oral formulation likely to replace other injectable GLP-1 receptor agonists? (2:12) 3. What have been the key take home messages from the PIONEER clinical trial programme? (3:02) 4. How does oral semaglutide compare with other oral agents such as empagliflozin and sitagliptin? (4:44) 5. Which patients are most likely to benefit from oral semaglutide? (5:37) Steve Bain has no conflicts of interest to declare in relation to this video. Filmed at the Annual Meeting of the European Association of the Study of Diabetes (EASD) Barcelona, Spain 2019.

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Our topic today is GLP-1’s, Part 2. In this episode I’m talking with Kellie Wilson, who is a favorite in the bariatric world. Kellie had bariatric surgery several years ago now and has used a GLP-1 at times. Kellie talks openly about a healthy use of GLP-1 medication and a time when she didn’t use it in the most healthy way! Resources: BariAfterare: www.bariaftercare.com Connie Stapleton PhD website: www.conniestapletonphd.com BariAftercare website: https://www.conniestapletonphd.com/bariaftercare BariAftercare Facebook page (for members only): https://www.facebook.com/groups/BariAftercare Kevin Stephens: Your Bariatric Buddy https://www.facebook.com/groups/yourbariatricbuddy/people Instagram: @cale101 (Caleshia Haynes) Instagram: @therealbariboss (Tabitha Johnson) Instagram @drsusanmitchell (Dr. Susan Mitchell) Instagram: @lauraleepreston (Laura Preston) ProCare Vitamins (10% off with code ConnieStapleton) Rob DiMedio: https://www.busybariatrics.com/ Dr. Joan Brugman: [email protected] Dr. Susan Mitchell: https://www.facebook.com/DrSusanMitchell https://www.facebook.com/bariatricsurgerystrategies Kellie Wilson: Instagram @bari.branded Facebook: https://www.facebook.com/sleevedfromtheashes

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