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A short, fun and informal web video with the interviewee (Graham) talking through his experiences with the lose one stone in one week diet. Enjoy and please share. For the full diet and further hints and tips, visit: https://www.vividphotovisual.com/blog/misc/lose-stone-week-menu/ or for Glen's experience click below: https://www.vividphotovisual.com/blog/fun/losing-stone-week-experience Vivid Photo Visual are a corporate web video and photography Company based in Manchester, England. To find out more visit http//www.vividphotovisual.com More YouTube Videos: http://www.youtube.com/user/VividPhotoVisual Lets connect: https://plus.google.com/117976041758302054742/about http://www.vividphotovisual.com http://www.facebook.com/vividphotovisual http://twitter.com/vividphotovis http://www.linkedin.com/pub/glen-mackintosh/12/1b9/5b3

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These drugs--Tirzepatide and Semaglutide--are not just changing the weight loss game. Every day new information is published regarding their efficacy in a wide range of chronic illnesses. They give us an exciting new tool for the management of complex illness. - The topic is GLP-1 receptor agonists (GLP-1 RAs), such as Ozempic, Wegovy, and Mounjaro (semaglutide and tirzepatide). - These drugs, originally developed for diabetes and weight loss, are being explored for broader benefits in patients with complex chronic illnesses, including long COVID and mast cell activation syndrome (MCAS). ### **Clinical Observations** - The hosts recount remarkable improvements in patients with severe, treatment-resistant symptoms (e.g., long COVID, MCAS) after starting very low doses of GLP-1 RAs. - Examples include: - A physician with disabling long COVID who, after starting a low dose of tirzepatide, regained mobility and improved overall function. - A woman with post-COVID and post-vaccine reaction, severe edema, food intolerance, and autoimmune markers, who experienced a dramatic reduction in swelling and improved food tolerance after just three injections. ### **Mechanisms & Theoretical Discussion** - GLP-1 is a natural hormone involved in insulin secretion and glucose metabolism; synthetic versions are longer-acting. - GLP-1 receptors are found throughout the body: central nervous system, muscles, immune cells (including mast cells), joints, and more. - The hosts hypothesize that the drugs’ benefits in complex illness may stem from: - Mast cell stabilization (reducing multi-system inflammation). - Modulation of immune function. - Effects on the central nervous system, possibly crossing the blood-brain barrier. - Notably, benefits are observed at microdoses (one-tenth or less of standard diabetes/weight loss doses), with minimal side effects. ### **Clinical Pearls & Practical Considerations** - Patients who are not overweight also benefit, and weight loss is minimal at these low doses. - Appetite suppression and improved food tolerance are common, leading to better quality of life. - The hosts encourage patients to re-challenge foods they previously could not tolerate after starting treatment. - There is curiosity about whether increasing the dose would yield further benefits or more side effects. - The drugs also seem to help with neurological symptoms, joint pain, and possibly even visual disturbances associated with long COVID. ### **Barriers and Logistics** - Insurance typically does not cover these drugs for off-label use, so patients rely on compounding pharmacies. - Recent FDA actions threaten the availability of compounded versions, as compounding is only allowed during official shortages. - Dosing compounded versions can be confusing, as patients must measure their own doses with insulin syringes, unlike the user-friendly commercial pens. ### **Mechanistic and Evolutionary Speculation** - The hosts discuss why GLP-1 receptors are so widespread, theorizing that modern diets and processed foods have disrupted normal physiology, and these drugs may help restore balance. - They propose that GLP-1 RAs could become important in anti-aging/longevity medicine due to their anti-inflammatory effects, similar to drugs like metformin and rapamycin. ### **Research & Future Directions** - The hosts call for more systematic data collection, including biomarkers of inflammation, to better understand and track the drugs’ effects. - They note the lack of robust clinical trial data for these off-label uses and suggest the need for case series and further research. - There is interest in comparing different GLP-1 RAs (semaglutide vs. tirzepatide) and their relative efficacy for inflammation vs. weight loss. ### **Conclusion** - The hosts are enthusiastic about the potential of GLP-1 RAs in treating complex chronic illnesses, especially given the rapid and profound improvements seen in some patients. - They plan to revisit the topic as more experience and data accumulate, and to explore combination therapy with other anti-inflammatory/anti-aging drugs like rapamycin. ## **Key Takeaways** - **GLP-1 receptor agonists, at very low doses, appear to provide significant, rapid benefits for some patients with chronic, complex illnesses (e.g., long COVID, MCAS), beyond their approved uses.** - **Benefits include reduced inflammation, improved mobility, better food tolerance, and improved neurological symptoms.** - **Mechanisms may involve mast cell stabilization, immune modulation, and central nervous system effects.** - **Access is limited by insurance and regulatory issues; compounded versions are threatened by FDA policy changes.** - **There is a need for more systematic research, including biomarker tracking and case series, to validate these observations.** - **GLP-1 RAs may have a future role in longevity and anti-aging medicine due to their anti-inflammatory properties.**

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Hormone Happy Hour - January 15 Meeting Purpose Impromptu Zoom meeting to discuss hormone therapy, client questions, and GLP-1 agonists. Key Takeaways Metformin can be beneficial for weight loss, PCOS, and gut health, but may deplete CoQ10 and B vitamins Bioidentical hormone replacement therapy (BHRT) can be safe and beneficial when properly administered and monitoredGLP-1 agonists may help with weight loss but should be used alongside lifestyle changes and proper nutrition education Topics Hormone Therapy and Fertility Copper peptide (GHK-CU) recommended for hair and skin health, safe for both men and women Metformin discussed as potential aid for PCOS, weight loss, and gut health Fertility optimization involves addressing inflammation, insulin resistance, and thyroid function BHRT benefits include bone, brain, and heart protection, with potential to reduce hip fractures, cardiovascular disease, and Alzheimer's risk GLP-1 Agonists for Weight Loss Potentially beneficial for severe food addiction or eating disordersMay cause digestive issues in those with pre-existing conditions Should be used short-term alongside proper nutrition educationEffectiveness depends on individual health status and ability to make lifestyle changes Hormone Feedback Mechanisms LH and FSH regulate hormone levels through feedback loops PCOS often presents with high LH and lower FSH, causing excess androgensMetformin can help lower LH pulse and regulate hormones in PCOS patients Supplements and Medications Berberine discussed as antimicrobial but often poorly tolerated For male fertility: high-quality vitamin D, methylated B vitamins, and L-carnitine recommended Compounded bioidentical hormones preferred over synthetic forms

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