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In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied.   We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss.   Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health. Access the full show notes, including referenced articles, books, people mentioned, and additional resources: https://www.hubermanlab.com/episode/dr-zachary-knight-the-science-of-hunger-medications-to-combat-obesity Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Zachary Knight UCSF academic profile: https://profiles.ucsf.edu/zachary.knight HHMI profile: https://www.hhmi.org/scientists/zachary-knight Publications: https://knightlab.ucsf.edu/publications Lab website: https://knightlab.ucsf.edu X: https://x.com/zaknight Instagram: https://www.instagram.com/zknightsf LinkedIn: https://www.linkedin.com/in/zachary-knight-29a37977 Timestamps 00:00:00 Dr. Zachary Knight 00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up 00:07:07 Hunger & Timescales 00:11:28 Body Fat, Leptin, Hunger 00:17:51 Leptin Resistance & Obesity 00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons 00:30:26 Sponsor: AG1 00:32:15 Body Weight & Obesity, Genes & POMC Neurons 00:39:54 Obesity, Genetics & Environmental Factors 00:46:05 Whole Foods, Ultra-Processed Foods & Palatability 00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning 00:58:55 Calories vs. Macronutrients, Protein & Salt 01:02:23 Sponsor: LMNT 01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure 01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy 01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea 01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects 01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133 01:34:49 Alpha-MSH & Pharmacology 01:40:41 Dopamine, Eating & Context 01:46:01 Dopamine & Learning, Water Content & Food 01:53:23 Salt, Water & Thirst 02:03:27 Hunger vs. Thirst 02:05:46 Dieting, Nutrition & Mindset 02:09:39 Tools: Improving Diet & Limiting Food Intake 02:14:15 Anti-Obesity Drug Development 02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter #HubermanLab #Health #Obesity Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://www.hubermanlab.com/disclaimer

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When it comes to weight loss, there are countless options available in the market, including diet plans, exercise routines, and weight loss pills. Among these, FDA approved weight loss pills have gained popularity as they are perceived to be safe and effective. However, it is essential to understand the safety and effectiveness of these pills before incorporating them into your weight loss journey.

Understanding the Safety of FDA Approved Weight Loss Pills

Before a weight loss pill can be approved by the Food and Drug Administration (FDA), it undergoes rigorous testing to ensure its safety. These tests evaluate the potential side effects of the pill and how it interacts with other medications. Additionally, the FDA monitors the pill’s safety after it hits the market, taking action if any concerning reports surface. This stringent process provides a level of assurance regarding the safety of FDA approved weight loss pills.

It is essential to remember that while FDA approved weight loss pills are deemed safe for consumption, they may still have side effects. Common side effects include nausea, constipation, headaches, and dizziness. It is crucial to consult with a healthcare professional before starting any weight loss pill to understand potential risks and ensure it is the right choice for you.

Furthermore, it is crucial to follow the recommended dosage and usage instructions provided with the weight loss pill. Taking more than the recommended amount can lead to adverse effects and negate any potential benefits. Additionally, combining multiple weight loss pills or using them alongside other medications without consulting a doctor can be dangerous.

Evaluating the Effectiveness of FDA Approved Weight Loss Pills

While FDA approved weight loss pills are considered safe, their effectiveness varies from person to person. It is essential to manage expectations and understand that these pills are not a magic solution for weight loss. They are designed to complement a healthy diet and regular exercise routine, enhancing your efforts rather than replacing them entirely.

When evaluating the effectiveness of a weight loss pill, look for scientific studies and clinical trials that support its claims. These studies provide insight into how the pill works, its impact on weight loss, and any potential benefits. Additionally, real-life testimonials from users can offer a perspective on the pill’s effectiveness beyond the data presented in studies.

It is important to approach FDA approved weight loss pills with a realistic mindset and be wary of products that promise drastic results with minimal effort. Sustainable weight loss requires commitment, dedication, and a holistic approach that includes not only the use of weight loss pills but also healthy lifestyle choices.

Navigating the World of FDA Approved Weight Loss Pills

With numerous FDA approved weight loss pills available in the market, it can be overwhelming to choose the right one for your needs. To make an informed decision, research different pills, their ingredients, and potential side effects. Consult with a healthcare professional to discuss your weight loss goals and determine the most suitable option for you.

When selecting a weight loss pill, consider factors such as your current health status, medical history, and any existing conditions. Certain weight loss pills may be contraindicated for individuals with specific health issues or medications. It is crucial to disclose all relevant information to your healthcare provider to ensure a safe and effective weight loss journey.

Remember that FDA approved weight loss pills are just one tool in your weight loss arsenal. Alongside the use of these pills, focus on maintaining a balanced diet, staying active, and practicing healthy habits that support your overall well-being. By combining these efforts, you can increase the likelihood of achieving sustainable weight loss results.

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