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This is the story of how GLP-1 receptor agonist drugs like semaglutide and tirzepatide were developed. Support my work on Nebula: https://go.nebula.tv/patrickkelly ☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️ 🎬C R E D I T S🎬 Written, performed, and edited by Patrick Kelly Select imagery/video supplied by Getty Images Thank you to Dr. Svetlana Mojsov and Rockefeller Institute for the use of Dr. Mojsov's portrait 🔗 L I N K S 🔗 📱Instagram: https://www.instagram.com/patkellyteaches/ 💰Patreon: https://www.patreon.com/corporis 🔬Old channel: www.youtube.com/corporis/ 📚Book recommendations: www.patkellyteaches.com/books 🔑 P A T R O N S 🔑 Oxytocin Tier: Mike W | Paul R | Daphnanne P | Oliver W | Tal Globus | Paul Belmes Growth Hormone Tier: Carey & Jack P | Brendan P | Brandon K | Kristofer R | Joe B | Mindi F | Michael G | Brian B | Eileen H | Waffles the Dog | Brian T | Brian H | Michael R | Karen S | Sarah B | Robin B | Jacob S | Hyeon-Seo | Paul! | Lucy Fur | Huynhy | Jim C | elnombre91 | Alcedo | Josef K | Dab B | Robert M | Jiggs | TierZoo | Seth G | Jane G | Jack M | Matthew B | Michelle J | Helena SB | Eric L | Ryne J | Kilian | Dean M | Cody S | Michelle L | Joseph G | Aryan R | Vic K | Becca | Jesse B | Stella | Marc M | Roxanna A | Doyle V | Maria A | Karen S | Jon A | Brian | Blake | Caitlin E | David W | DrCredibleHulk | Eugene F | Anthony DiF | Charlie C | Reniece J | chris | Rachel J | ZoeMarie | Katie B-S | Broderic D | CJ 📜 S O U R C E S 📜 An annotated version of the script can be found on Patreon: https://www.patreon.com/posts/glp-1-video-133601476?utm_medium=clipboard_copy&utm_source=copyLink&utm_campaign=postshare_creator&utm_content=join_link Novo Nordisk (2023) by Kurt Jacobsen The discovery and development of GLP-1 based drugs that have revolutionized the treatment of obesity (2024) https://www.pnas.org/doi/10.1073/pnas.2415550121 Glucagon as the First Incretin: Objects (in the Rearview Mirror) Are Closer Than They Appear (2023) https://diabetesjournals.org/diabetes/article/72/12/1739/153849/Glucagon-as-the-First-Incretin-Objects-in-the The development of Byetta (exenatide) (2012) https://www.sciencedirect.com/science/article/pii/S0041010110004472 The time has come for incretins, a long time coming (2010) https://link.springer.com/content/pdf/10.1007/s00109-009-0586-5.pdf Dual GIP–GLP1-Receptor Agonists In The Treatment Of Type 2 Diabetes: A Short Review On Emerging Data And Therapeutic Potential (2019) https://www.dovepress.com/article/download/48870 Type 2 Diabetes https://diabetesatlas.org/media/uploads/sites/3/2025/02/IDF-Atlas-2nd-Edition.pdf https://diabetes.org/about-diabetes/type-1 https://www.ncbi.nlm.nih.gov/books/NBK507839/ https://www-sciencedirect-com.harker.idm.oclc.org/science/article/pii/S0169409X02000935?via%3Dihub FDA Shortages: https://www.fda.gov/media/185526/download?attachment 💻 C O N T A C T 💻 patkellyteaches [at] gmail.com ⌛T I M E S T A M P S ⌛ 0:00 intro 0:52 GLP-1 as a hormone 9:50 GLP-1 as a diabetes drug 13:00 exenatide 16:21 liraglutide 19:20 GLP-1 as an obesity drug 24:25 dulaglutide 25:23 semaglutide 28:40 tirzepatide 30:45 Compounding pharmacies 33:26 Conclusion #historyofmedicine #medicalhistory

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https://smarturl.it/loseweightpil Click the link to try this powerful fat burning supplement! Everyone's been talking about the keto Keto Advanced from shark tank and other tv shows and websites, so I tried them out and made this video to share my incredible results! Shark Tank Keto Advanced (My Story!) I've experienced significant weight loss while using these keto pills, it's really been amazing. So far I've lost a total of 36 pounds and I've only been taking them for one month! I haven't noticed any side effects at all, except I don't crave sweets as much, which is definitely a good thing! The shark tank weight loss pills put your body into ketosis, which is a naturally occurring state where your body burns its own fat for energy. This is why they start working so fast, because with some weight loss supplements your body takes a while to adjust, but with this keto supplement it's natural and your body knows what to do right away. If you want to try the keto Keto Advanced, go to the website where I got mine: https://smarturl.it/ketopills #ketodietpills​ #ketodietpillsreview​ #dietpillsreview​ ___________________________________ Tags: shark tank Keto Advanced, keto Keto Advanced from shark tank, keto pills from shark tank, shark tank weight loss episode, shark tank Keto Advanced keto, keto Keto Advanced review, keto diet pill shark tank, shark tank diet pill reviews, keto weight loss pills review, shark tank keto episode, shark tank weight loss episode 2019, keto pills shark tank review, strong keto bhb shark tank, keto pills shark tank reviews

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I struggled with weight and blood sugar swings — and keto just wasn’t sustainable for me. Then my doctor introduced me to Berberine, and everything changed. Berberine helps activate AMPK, often called your body’s "metabolic master switch." It's a natural way to support: ✅ Weight management ✅ Blood sugar stability ✅ Better energy levels ✅ Overall metabolic health I now take Native Berberine, made from clean botanical ingredients like Barberry root, Goldenseal, and Oregon grape. ✨ It’s simple: 1 capsule in the morning, 1 at night — and no restrictive diet needed. 👉 Try Native Berberine here: https://tinyurl.com/phcollagen #berberine #ketoalternative #naturalhealth #weightmanagement #nativepath

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Understanding Chrissy Metz and Her Journey

Chrissy Metz, widely recognized for her compelling role as Kate Pearson on the hit NBC television series “This Is Us,” has become a beacon of hope and inspiration for millions around the world. Her journey has not only captivated audiences through her performances but also touched hearts with her real-life struggles and triumphs, particularly regarding weight loss. Metz’s openness about her personal battles with weight has made her an advocate for body positivity and self-acceptance. While many may see her as just an actress, her story extends far beyond the silver screen. It’s a narrative of resilience, passion, and commitment to change.

Metz has grappled with her weight since childhood, a struggle that many can relate to. Growing up in a society that often prioritizes thinness, she faced bullying and criticism, which affected her self-esteem and mental health. Despite these challenges, Chrissy developed a love for acting and storytelling, which became outlets for her emotions. Her path was neither straightforward nor easy; it was filled with challenges that tested her strength. However, her commitment to her craft eventually led her to success, allowing her to translate her struggles into relatable characters that resonate with audiences.

As Metz rose to fame, she decided to take charge of her health both for her own sake and as an example to her fans. This pivotal moment led to her incredible 100-pound weight loss journey. She started to adopt healthier lifestyle choices, focusing on nutrition and exercise while also addressing emotional aspects tied to her relationship with food. Her decision to lose weight was not just for aesthetic reasons but stemmed from her desire to improve her overall well-being and to combat the underlying health issues associated with obesity. This decision has inspired many fans to take a step towards healthier living.

The Decision to Change

One of the most significant turning points in Chrissy Metz’s life was the moment she decided to embark on her weight loss journey. This decision was not made lightly; it stemmed from a deep-seated desire to improve her health. Recognizing the impact that her weight had on her life, she sought the guidance of doctors and nutritionists to understand the long-term effects her lifestyle choices could have. Metz’s realization of the health risks associated with her weight was a catalyst for change. She recognized that her decision to lose weight was not merely about appearance but rather about achieving a holistic sense of well-being.

The beginning of Metz’s weight loss journey involved adopting a balanced diet. Instead of resorting to extreme dieting methods that could jeopardize her health, she focused on creating sustainable eating habits. By making gradual changes to her meals, she learned to embrace whole foods filled with nutrients while reducing processed food consumption. These dietary adjustments opened the door to not just weight loss but also enhanced energy levels and improved mental clarity. Chrissy took an honest approach to her food choices, realizing that indulging every so often did not equate to failure but rather to moderation.

In tandem with dietary changes, Metz incorporated physical activity into her daily routine. Initially, the prospect of exercising regularly was daunting. However, she saw it as an opportunity to explore various fun activities that kept her motivated. From walking to engaging in group fitness classes, each small step boosted her confidence. The more she moved, the more she discovered the joy of physical activity. This newfound enthusiasm not only aided in weight loss but also fostered a sense of community with others who shared similar fitness goals. The combination of mindful eating and consistent exercise laid the foundation for her transformative journey.

Overcoming Mental Barriers

Beneath the physical changes that Chrissy Metz underwent, a profound mental shift occurred. One of the most challenging aspects of her journey was confronting the emotional connections she had with food. Growing up, Metz sometimes turned to food for comfort during difficult times, and identifying these triggers was crucial in breaking unhealthy patterns. Therapy played a significant role in helping her understand her emotions better and develop healthier coping mechanisms. It was through professional support that she learned the importance of self-acceptance and self-love.

Additionally, Chrissy faced societal expectations and pressures regarding her body image. Being in the public eye magnified her challenges, but she used this visibility as a platform to advocate for authenticity and acceptance. Metz became vocal about the struggles that many individuals endure concerning body image, making it her mission to promote a narrative of strength in vulnerability. Her candidness about her insecurities resonated with many, proving that openness about one’s struggles could foster unity among those facing similar challenges.

The journey to mental well-being also involved celebrating small victories. Metz learned to appreciate each milestone, whether it was a pound lost or simply feeling more energetic. By recognizing the importance of self-compassion, she cultivated a positive relationship with her body. Emphasizing progress over perfection became her mantra, allowing her to enjoy the journey rather than obsess over the destination. This mental transformation was just as crucial as the physical changes, ultimately leading to a more fulfilling and balanced life.

Sharing Her Story

Chrissy Metz’s willingness to share her weight loss journey has inspired countless individuals, serving as a testament to the power of vulnerability and authenticity. By openly discussing her experiences, she has created a supportive community of followers who relate to her struggles. Her story reflects the notion that change is possible, no matter the starting point, and that one needs to confront not only the physical challenges but also the emotional ones. Through interviews, social media platforms, and public appearances, Metz has used her platform to shed light on the realities of weight loss and the importance of self-acceptance.

In addition to her personal narrative, Metz has inspired others to embrace their journeys, emphasizing the significance of community and support systems. She advocates for individuals to share their experiences, no matter how daunting. By highlighting the importance of connection and understanding, she encourages others to step out of isolation and into a network of shared experiences. This approach cultivates an environment where individuals can empower each other, creating a ripple effect that encourages more people to be vulnerable and honest about their challenges.

Moreover, Chrissy’s story extends beyond her personal life; it integrates into her professional career as well. Her portrayal of Kate Pearson has received accolades, in part because of the authenticity she imbues into the character, which mirrors her real-life struggles. Through art, Metz communicates her message that authenticity stems from one’s ability to share their story, embrace imperfections, and find strength in vulnerability. This alignment between her personal journey and her professional endeavors reinforces her role as a powerful advocate for body positivity and self-love.

A New Chapter: Maintaining a Healthy Lifestyle

As Chrissy Metz continues her journey, maintaining a healthy lifestyle has become her primary focus. The 100-pound weight loss was not merely a destination but a significant transformation that she intends to uphold. Metz emphasizes that embracing a healthy lifestyle is an ongoing process, requiring continuous dedication and effort. Rather than viewing it as a one-time achievement, she understands the importance of making mindful choices daily to preserve her well-being and stay motivated on her path. This realization is pivotal in showcasing how sustainable practices yield long-term benefits, confirming that health is a lifelong commitment.

In her pursuit of healthier living, Chrissy has learned the importance of balance. This means allowing herself the occasional treat without feeling guilty, which fosters a commendable relationship with food. By following a balanced approach, she continues to enjoy meals, explore new recipes, and maintain a fulfilled life while prioritizing her health. This moderation not only aids her physical health but also supports her emotional well-being, enhancing her overall quality of life.

Community support also remains integral to Metz’s success. Engaging with fellow supporters who share similar aspirations contributes to her motivation and accountability. This network aids in sustaining healthy habits, exchanging recipes, fitness routines, and tips for maintaining mental health. Metz has highlighted how these connections foster resilience and create a supportive environment for people to grow together. Ultimately, her emphasis is not solely on weight loss, but rather on the holistic journey of embracing life, fostering relationships, and cultivating joy.

Celebrating the Journey

Chrissy Metz’s weight loss journey goes far beyond the numbers on a scale; it celebrates resilience, courage, and self-discovery. By sharing her story, she encourages others to embrace their transformations, acknowledging that everyone’s journey is unique and personal. This celebration is not about achieving a ‘perfect’ body but rather about feeling good within oneself. Metz’s transparent narrative challenges societal views on beauty, reinforcing the idea that self-love and acceptance triumph over temporary aesthetic standards.

The importance of community and connection stands at the forefront of Metz’s philosophy regarding personal growth. Celebrating each other’s stories can foster an environment of encouragement that inspires individuals to take charge of their health. Chrissy’s journey serves as a reminder that every step, no matter how small, is worthy of recognition and appreciation. This culture of celebration cultivates positivity surrounding body image, allowing individuals to take pride in their efforts and progress.

In concluding her journey, Metz has reminded her followers that transformation is not about perfection; it’s about continuous growth and learning. Her candidness about setbacks, triumphs, and everything in between creates realistic expectations for those embarking on similar journeys. Ultimately, Chrissy Metz’s narrative is an invitation for individuals to appreciate their unique paths and to embrace their worth, passion, and potential while living authentically and confidently.

Summary and Frequently Asked Questions

Chrissy Metz’s inspiring journey of losing 100 pounds resonates with many who face their own battles with weight and self-image. Her story reflects the powerful interplay between physical health and mental well-being, making her narrative rich with lessons for those aiming for similar transformations. Transitioning from a place of vulnerability to one of strength, Metz has become a symbol of hope, encouraging people to confront their challenges with grace and tenacity.

Many often wonder about the specifics of her journey, including the methods she employed to achieve such significant weight loss. Chrissy Metz has openly shared that it involved a combination of mindful eating, regular physical activity, and addressing the emotional aspects associated with food. The essential lesson here is that weight loss is not about quick fixes but rather about developing sustainable habits, seeking support, and engaging in positive self-talk.

Another common query regards how she maintains her new healthy lifestyle. Metz emphasizes the importance of balance, ensuring that she treats herself occasionally without derailing her overall health goals. She advocates for embracing food as a source of nourishment and enjoyment while fostering a positive relationship with it. This healthy perspective aids in sustaining her transformed lifestyle, proving that it is possible to prioritize health without sacrificing joy. Through her story, Chrissy Metz continues to inspire others to celebrate their journeys, no matter the ups and downs.

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YOUR SPECIAL DISCOUNT IS: $100 OFF $199 CLICK THE LINK AND ORDER NOW! https://sale.torroband.com/?affId=38C84326 CAN YOU BURN FAT WITH RESISTANCE BAND? Can You Lose Fat With Resistance Band? The answer is "YES," since resistance bands are a simple and effective way to begin strengthening your muscles and burning fat. If you begin with a low level of resistance, it will allow you to gradually increase your exercise strength. Resistance band workouts help you lose fat by increasing the number of calories you burn at rest by improving both after burn and muscle size. However, after completing the resistance band workout, oxygen intake remains high in order to return muscles to their resting state by breaking down stored fat and carbs, resulting in weight loss and fat burn. We'll look into the ideal resistance band workout for beginners based on the various types. These workouts will be categorised as follows: Upright Row Hold the handles with your hands facing inwards, resting on your thighs, while standing on a resistance band. Keep your back straight and your elbows higher than your forearms as you push the band up towards your chin. rep from the beginning. Shoulder Press Hold the other end of a resistance band at shoulder height with your hands facing forward. Extend your arms straight above your head, somewhat wider than shoulder width. Return the band to its original position and repeat the process. Reverse Fly With each hand, grab a handle on your shins while standing on a resistance band. Bend your knees slightly and lower your back to the floor. Raise your arms as far as possible to the side. Repeat with a pause before lowering the band to its initial position. Adding muscle during a bulk is an excellent strategy to boost long-term muscular growth and strength. When trying to bulk up quickly, it's also crucial to know how fast your body can gain weight, as acquiring too much weight too quickly might lead to excessive body fat gain. Use the suggestions above to help you get the most out of your next muscle-building phase and learn how to bulk up as quickly as possible. LICENSE CERTIFICATE: Envato Elements Item ================================================= This license certificate documents a license to use the item listed below on a non-exclusive, commercial, worldwide and revokable basis, for one Single Use for this Registered Project. Item Title: This is Workout Item URL: https://elements.envato.com/this-is-workout-RC4KRXD Item ID: RC4KRXD Author Username: TwoCatsGang Licensee: Chancy Bolo Registered Project Name: ChancyFit License Date: December 21st, 2021 Item License Code: A3T67UYENB The license you hold for this item is only valid if you complete your End Product while your subscription is active. Then the license continues for the life of the End Product (even if your subscription ends). For any queries related to this document or license please contact Envato Support via https://help.elements.envato.com/hc/en-us/requests/new Envato Elements Pty Ltd (ABN 87 613 824 258) PO Box 16122, Collins St West, VIC 8007, Australia ==== THIS IS NOT A TAX RECEIPT OR INVOICE ==== Visit my Website: https://chancyfit.com/virtual-training/ Let's Connect on Instagram: https://www.instagram.com/chancyfit/ Let's Connect on Facebook: https://www.facebook.com/chancyfit/ #ChancyFit

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Today, Mel sits down with world-renowned, triple board certified endocrinologist and obesity specialist, Dr. Rocio Salas-Whalen, to explain the medical truth behind your metabolism, weight loss, and the most talked-about medications on the planet: GLP-1s like Ozempic and Wegovy. Today, she’s breaking down exactly how these medications work, who they’re for, and the critical mistakes people are making when using them without medical supervision. If you're confused about these drugs, worried about the side effects, or curious if they could help you or someone you love—this episode will answer every question you've been too afraid to ask. #1 Weight Loss Doctor The Truth About Obesity Ozempic Dieting & How to Feel Better Now weight loss,ozempic,ozempic weight loss,obesity,doctor mike,the lies about the ozempic weight loss craze,weight loss journey,ozempic side effects,weight loss tips,ozempic weight loss stories,ozempic for weight loss,ozempic alternatives for weight loss,doctor reacts,ozempic weight loss results,ozempic - how it works for weight loss,ozempic weight loss before and after,weight loss drugs,ozempic weight loss plateau,ozempic stalled weight lossozempic weight loss,ozempic,weight loss,ozempic weight loss before and after,ozempic side effects,ozempic weight loss stories,obesity,ozempic weight loss results,weight loss drugs,weight,ozempic face,wegovy weight loss,how ozempic helps with weight loss,what does ozempic do to your body for weight loss,ozempic for weight loss,weight loss injections,weight loss ozempic,ozempic - how it works for weight loss,weight loss journey ozempic weight loss,ozempic,weight loss,ozempic weight loss before and after,ozempic side effects,ozempic weight loss stories,obesity,ozempic weight loss results,weight loss drugs,weight,ozempic face,wegovy weight loss,how ozempic helps with weight loss,what does ozempic do to your body for weight loss,ozempic for weight loss,weight loss injections,weight loss ozempic,ozempic - how it works for weight loss,weight loss journey #WeightLossDoctor #ObesityTruth #Ozempic #HealthyDieting #FeelBetterNow #WeightLossJourney #NutritionMatters #HealthAndWellness #LifestyleChange #EmpowerYourself Mel Robbins, Mel Robbins Motivation, , Robbins Advice, inspiration weight loss tips, dry fasting weight loss, lose weight, Weight loss, weight loss journey, exercise, healthy eating, trainwell weight loss, nutrition, calorie deficit, intermittent fasting, meal prep, workout, fitness, fat loss, wellness, healthy lifestyle, noom weight losss, vegan weight loss, body transformation weight loss tips, dry fasting weight loss, lose weight, Weight loss, weight loss journey, exercise, healthy eating, trainwell weight loss, nutrition, calorie deficit, intermittent fasting, meal prep, workout, fitness, fat loss, wellness, healthy lifestyle, noom weight losss, vegan weight loss, body transformation you're confused about these drugs, worried about the side effects, or curious if they could help you or someone you love—this episode will answer every question you've been too afraid to ask. In this episode, you’ll learn: -The 5 real causes of weight gain—and why only one is in your control -Why obesity is not your fault (and how blaming yourself is holding you back) -What GLP-1 medications like Ozempic actually do in your body -The #1 risk no one is talking about when taking these drugs -Why these medications can change your brain, your cravings, and your relationship with food -How to avoid “Ozempic face,” hair loss, and muscle loss while on these drugs -How to know if you’re a good candidate—and the red flags to watch out for You’ll also hear Dr. Salas-Whalen’s personal story of using the medication herself after hitting perimenopause—and what she wants every woman to know about managing weight in midlife.