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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)
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Lori Greiner is a household name thanks to her role as an investor on the hit TV show Shark Tank. Aside from her success in the business world, Lori has also been open about her struggles with weight loss. In recent years, she has become an advocate for health and wellness, inspiring many with her own journey to a healthier lifestyle. One of the products that Lori has endorsed is a weight loss pill that has gained popularity after appearing on Shark Tank. In this article, we will delve into the insights and impact of Lori Greiner’s weight loss pill, exploring its effectiveness and the potential benefits it offers to those looking to shed some extra pounds.
Shark Tank Appearance
Lori Greiner’s weight loss pill made its debut on Shark Tank, where it caught the attention of the investors and viewers alike. The pill claimed to be a natural and safe solution for weight loss, prompting a heated discussion among the sharks. Lori’s passion for the product was evident as she shared her own journey to better health and the role the pill played in her transformation. This endorsement from a well-known figure like Lori gave the product instant credibility and generated a buzz around its potential benefits.
As the sharks questioned the creators of the weight loss pill about its ingredients and effectiveness, Lori stood by the product, touting its ability to aid in weight loss without harmful side effects. Her confidence in the pill’s benefits was infectious, and it ultimately led to a successful deal being struck on the show. The exposure from Shark Tank propelled the weight loss pill into the spotlight, drawing interest from consumers who were eager to see if it could live up to the hype.
Effectiveness and Benefits
Since its appearance on Shark Tank, Lori Greiner’s weight loss pill has gained a loyal following of users who swear by its effectiveness. Many have reported significant weight loss results after incorporating the pill into their daily routine, attributing their success to the pill’s ability to curb cravings and boost metabolism. The natural ingredients in the pill have been praised for their ability to promote fat burning and increase energy levels, making it easier for users to stick to their weight loss goals.
Aside from aiding in weight loss, the pill has also been credited with improving overall health and well-being. Users have reported feeling more energetic, focused, and motivated to make healthy choices while taking the pill. The convenience of simply taking a pill to support their weight loss journey has made it an attractive option for those with busy lifestyles who struggle to find the time for traditional diet and exercise routines. The pill’s ability to provide a natural and safe solution to weight loss has resonated with many who are wary of harsh chemicals and artificial ingredients found in other supplements on the market.
Customer Reviews and Testimonials
Customer reviews of Lori Greiner’s weight loss pill have been overwhelmingly positive, with many users raving about the results they have achieved while taking the product. The pill has received praise for its ability to suppress appetite, increase metabolism, and promote fat loss, leading to noticeable changes in weight and body composition. Users have shared their success stories online, detailing how the pill has helped them overcome plateaus, break through stubborn weight loss barriers, and achieve their desired physique.
Testimonials from satisfied customers have highlighted the pill’s impact on their lives, with many expressing gratitude for the newfound confidence and energy they have gained through their weight loss journey. The pill’s ability to support long-term weight management and lifestyle changes has been a key factor in its popularity, as users appreciate the sustainable results it offers. Overall, the positive feedback and testimonials surrounding Lori Greiner’s weight loss pill serve as a testament to its effectiveness and the impact it has had on the lives of those who have tried it.
Final Thoughts
As we have explored the insights and impact of Lori Greiner’s weight loss pill, it is clear that the product has had a significant influence on the weight loss industry. Its appearance on Shark Tank and endorsement by Lori Greiner have helped to elevate its profile and generate interest from consumers seeking a safe and effective solution for weight loss. The pill’s natural ingredients, proven effectiveness, and positive customer reviews have established it as a reputable option for those looking to shed extra pounds and improve their overall health.
Whether you are just starting your weight loss journey or looking for a supplement to support your existing efforts, Lori Greiner’s weight loss pill may be worth considering. With its track record of success and loyal following of users, the pill offers a promising solution for those who are committed to achieving their weight loss goals in a safe and sustainable way. Take inspiration from Lori’s own transformation and the many success stories shared by users of the pill, and embark on your own journey to a healthier, happier you.
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Are you stuck on your weight loss journey and wondering why the scale isn’t moving? You’re not alone! In this video, I break down 10 common reasons why your weight loss has plateaued—and what you can do to start seeing results again. Whether it’s sneaky eating habits, a slowed metabolism, or just plain stress, I’m giving you real talk and practical tips to help you stay on track. If you’re over 50 and working toward a healthier lifestyle, this one’s especially for you! Subscribe for more wellness tips, midlife motivation, and real talk from your favorite Auntie. #WeightLossOver50 #MidlifeHealth #WeightLossPlateau #HealthyLifestyle #FitnessOver50 #WeightLossJourney #FatLossTips #WellnessWithAuntie #WomenOver50 #AntiAgingFitness #StalledWeightLoss #LoseWeightNaturally
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In today’s fast-paced world, many people struggle to find the time to prepare healthy meals and snacks. This often leads to poor food choices and weight gain. For those looking to manage their weight more effectively, finding convenient and delicious solutions is key. One such solution is Smooth Kickin Keto Gummies, a tasty and satisfying snack that can support your weight management goals.
Benefits of Smooth Kickin Keto Gummies
Smooth Kickin Keto Gummies are specially formulated to help you stay on track with your keto diet while satisfying your sweet cravings. These gummies are low in carbs and sugar, making them a guilt-free treat that won’t derail your weight loss efforts. Plus, they are packed with essential nutrients and vitamins to support your overall health and well-being.
One of the key benefits of Smooth Kickin Keto Gummies is their convenience. Whether you’re on the go or looking for a quick and easy snack option, these gummies are the perfect choice. Simply grab a few gummies whenever you need a boost of energy or a tasty treat.
Another benefit of Smooth Kickin Keto Gummies is their versatility. You can enjoy these gummies as a standalone snack or incorporate them into your favorite keto recipes. From smoothie bowls to baked goods, the possibilities are endless when it comes to incorporating these tasty gummies into your diet.
How Smooth Kickin Keto Gummies Can Support Weight Management
Smooth Kickin Keto Gummies are designed to help you stay on track with your weight management goals by providing a delicious and satisfying snack option. By incorporating these gummies into your daily routine, you can curb your cravings for sugary treats and stay on track with your keto diet.
One way that Smooth Kickin Keto Gummies support weight management is by helping to regulate blood sugar levels. By consuming low-carb, low-sugar snacks like these gummies, you can avoid spikes and crashes in blood sugar that can lead to overeating and weight gain.
Additionally, Smooth Kickin Keto Gummies are a great source of healthy fats, which can help keep you feeling full and satisfied between meals. This can help prevent overeating and support your weight loss efforts in the long run.
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When it comes to finding a tasty and convenient snack option that supports your weight management goals, Smooth Kickin Keto Gummies are the ideal choice. These gummies are made with high-quality ingredients and are free from artificial flavors, colors, and preservatives.
Unlike other snacks on the market, Smooth Kickin Keto Gummies are specifically formulated to align with keto principles, making them a great option for those following a low-carb, high-fat diet. Whether you’re new to keto or a seasoned pro, these gummies can help you stay on track with your diet and reach your weight management goals.
With their delicious taste and satisfying texture, Smooth Kickin Keto Gummies are sure to become a staple in your snack rotation. Say goodbye to bland and boring keto snacks and hello to a tasty and convenient option that can support your weight management journey.
FAQs About Smooth Kickin Keto Gummies
1. Are Smooth Kickin Keto Gummies suitable for vegetarians and vegans?
Yes, Smooth Kickin Keto Gummies are vegetarian and vegan-friendly. They are made with plant-based ingredients and do not contain any animal products.
2. Can I eat Smooth Kickin Keto Gummies on a non-keto diet?
While Smooth Kickin Keto Gummies are designed with keto principles in mind, they can be enjoyed as a delicious and nutritious snack regardless of your diet preferences.
3. How many gummies should I eat in a serving?
The recommended serving size for Smooth Kickin Keto Gummies is 2-3 gummies. However, you can adjust the serving size based on your personal preferences and dietary needs.
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