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Learn more about becoming an Insider on my website: https://www.benbikman.com Study referenced in this video: “The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity”: https://pubmed.ncbi.nlm.nih.gov/11439290/ In this short answer to a question recently asked by one of our community members, Dr. Bikman addresses the relationship between GLP-1 and insulin resistance, particularly about why GLP-1 is considered beneficial if it stimulates insulin production. Ben acknowledges this question as critical and notes that misconceptions about GLP-1, especially concerning weight-loss drugs like semaglutide, have been widely weaponized in debates about insulin and insulin resistance. According to Ben, the perceived contradiction arises from the belief that GLP-1 increases insulin while simultaneously reducing appetite, leading to less food intake. Dr. Bikman explains that such a combination—reduced food intake with increased insulin—would theoretically be lethal because insulin’s role in removing glucose from the blood would deprive the brain of both glucose and ketones, essential energy sources. This lethal metabolic shift, however, does not occur with GLP-1 drugs because, as Dr. Bikman clarifies, these drugs do not significantly stimulate insulin release in humans. Citing a study by Dr. A. Astrup, a leading scientist at Novo Nordisk, Dr. Bikman emphasized that GLP-1 activation does not increase insulin release in humans. He expressed respect for Dr. Astrup and his research, noting that while he has reservations about the overuse of GLP-1 drugs, this particular study convincingly supports that GLP-1 does not induce the insulin release often presumed in debates. visit: https://www.insuliniq.com Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: Ben10) #InsulinResistance #GLP1 #MetabolicHealth #WeightLossDrugs #DrBenBikman #Semaglutide #InsulinScience #GLP1Insights #MetabolismMatters #WeightLossScience #HealthDebates #GLP1VsInsulin #NovoNordiskStudy #MetabolicLecture #ScienceExplained #GLP1Benefits #Ketogenesis #WeightLossFacts #MetabolicClassroom #DiabetesResearch

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In this episode of the Transformation Weight Control Podcast, Alex and Rich, along with TWC participant and guest Marc G, discuss the complexities of weight loss, the role of medication, and the importance of lifestyle changes. Marc shares his personal journey of struggling with obesity, the impact of food noise, and how medication has transformed his relationship with food. The conversation emphasizes the significance of exercise, the challenges of societal biases regarding weight, and the importance of community support in achieving lasting change. Marc participates in the TWC Weight Loss Medication Support Group, the only one in the country, which meets once a week for 75 minutes led by health-care professionals including a registered dietitian. For more information you can click here: https://transformationweightcontrol.com/12-week-weight-loss-medication-support-group/ or email Rich Weil, TWC Director, at [email protected] CHAPTERS: 00:00 Introduction to Transformation Weight Control Podcast 02:35 Marc's Weight Loss Journey: Struggles and Triumphs 11:38 The Role of Medication in Weight Management 18:17 Understanding Food Addiction and Mental Noise 24:31 Normalizing Appetite Regulation and Portion Control 42:24 Transformative Experiences with Weight Loss Medications 44:48 Mindfulness and Nutrition Tracking 47:39 Adapting Diet for Health and Energy 50:27 Incorporating Exercise into Daily Life 52:37 Addressing Medication Bias and Chronic Disease 59:37 The Role of Community Support in Weight Loss 01:05:48 Final Thoughts on Weight Loss Journey and Medications

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There are a few off-label medications for weight loss. The off-label medications are the FDA-approved drugs that are used for Unapproved indications. Most of the off-label meditations for weight loss are inexpensive if you use the good RX coupons or fill them at Walmart pharmacy. 60 tablets of 1000 mg metformin costs $4 at Walmart pharmacy. acarbose costs less than $20 a month at Costco pharmacy with a goodRX coupon. miglitol is a little bit pricy. It is priced at about $100 at Costco pharmacy even with a goodRX coupon. Bupropion is also inexpensive. At the dose of 300mg a day, it costs about $12 a month at Costco pharmacy with a goodRX coupon. 30 tablets of 40mg Fluoxetine costs $4 at Walmart pharmacy At Costco pharmacy with a goodRX coupon, Zonisamide, at the dose of 400mg a day, costs about $18 a month and Topiramate at the dose of 100 mg a day costs about six dollars a month.

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