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Downsized News: Breakthroughs and Industry Shifts in GLP-1 Treatments In this episode of the Downsized News, Laraine and Christopher Durham deliver the latest updates on GLP-1 medications on Monday, June 2nd, 2025. Key topics include significant data releases by Eli Lilly at the upcoming American Diabetes Association's Scientific Sessions concerning Tirzepatide's effects on kidney function and weight loss compared to Semaglutide. The episode also explores new forms of GLP-1 treatments, such as the Orfroglipron pill and the Retatrutide triple-action hormone, as well as an updated weekly insulin option by Lilly. Additionally, a comprehensive breakdown of a study on high-dose Semaglutide treatments for diabetes and obesity discusses the balance between increased weight loss and rising side effects. The discussion shifts to industry challenges, like Hims Inc.'s layoffs due to FDA crackdowns on compounded GLP-1s, and a new ISSA course designed to help athletic trainers support GLP-1 users. Also covered is the intense industry debate over compounded medications, a major court ruling in India impacting Semaglutide sales, and competitive developments in China's obesity treatment market. The episode concludes with highlights of an innovative partnership between Nxtera Pharma and Eli Lilly aiming at new metabolic treatments. The hosts encourage viewers to stay informed and share personal insights on navigating GLP-1 treatments. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Overview 01:04 Eli Lilly's Latest Data and Innovations 05:21 High Dose Semaglutide Study Insights 10:14 Hims Layoffs and FDA Crackdown 11:51 New Training Course for GLP-1 Trainers 13:58 Compounded Medications Debate 17:08 Legal Battles and Market Dynamics in India 20:16 NextEra Pharma and Eli Lilly Partnership 21:52 Upcoming Competition in China's GLP-1 Market 24:25 Conclusion and Final Thoughts

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Weight reduction is the process of reducing the amount of fat and excess weight in the body. It can be achieved through a healthy and balanced diet and regular physical activity. Reducing weight requires determining the number of calories you should eat per day and reducing them gradually to achieve a negative calorie difference, which is when you eat less calories than your body needs, which leads to burning stored fat in the body to convert it into energy. In addition, it is recommended to practice light to moderate exercise regularly to improve fitness and increase calorie burning. Care should be taken to eat healthy foods such as fruits, vegetables and healthy proteins, and avoid eating foods high in fats and sugars. Although reducing weight can be a challenge, it can significantly improve your health and reduce the risk of several chronic diseases such as heart disease, diabetes, high blood pressure, and cancer. Click on the link in the first comment

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Burn fat with GCN's turbo training session. Get lean, burn calories and get fit with our 30 minute indoor cycling session. This workout is designed to replicate a hill intervals. Subscribe to GCN: http://gcn.eu/SubscribeToGCN Get exclusive GCN gear in the GCN shop! http://gcn.eu/3h This class is ideal if you want to lose weight and get fit and have time to train before work or during your lunch break. Designed to replicate the feeling of a hill interval training session, this workout gradually ramps up to provide as much resistance as possible in the last few minutes. We can vouch for this turbo class too – we use it regularly! Thanks to Lucy Martin (@LUCYMARTIN05), Jessie Walker (@jesiwak) and Emily Collins (@EmilyCollins_NZ) for joining us! Many thanks to The Club & Spa at Cadbury House for the use of their Studio www.theclubandspabristol.co.uk/the-spa/ www.twitter.com/theclubcadbury www.facebook.com/ClubandSpaBristol/ This workout is ideal for an indoor bike, a turbo trainer or smart trainer and even the rollers. Try it and tell us how you do in the comments! 👇 As with any strenuous exercise, you should consult a doctor/physician before beginning a programme of exercise. Discontinue your exercise session immediately if you experience any pain, dizziness or discomfort. Partaking in training sessions following GCN's video instruction is entirely at your own risk, and Global Cycling Network can not be held responsible for any injuries which may occur as a result of these exercises. Watch more on GCN... Essential cycling tips 📹 http://gcn.eu/3i 3 killer workouts 📹 http://gcn.eu/3j Buy NEW GCN cycling kit, casual wear and accessories in the GCN Shop: http://gcn.eu/3h About GCN: The Global Cycling Network puts you in the centre of the action: from the iconic climbs of Alpe D’Huez and Mont Ventoux to the cobbles of Flanders, everywhere there is road or pavé, world-class racing and pro riders, we will be there bringing you action, analysis and unparalleled access every week, every month, and every year. We show you how to be a better cyclist with our bike maintenance videos, tips for improving your cycling, cycling top tens, and not forgetting the weekly GCN Show. Join us on YouTube’s biggest and best cycling channel to get closer to the action and improve your riding! Welcome to the Global Cycling Network | Inside cycling Thanks to our sponsors: Alta Badia: http://gcn.eu/AltaBadia_ // Maratona Dles Dolomites: http://gcn.eu/MaratonaDlesDolomites_ Assos of Switzerland: http://gcn.eu/2hcDLGM KASK helmets: http://gcn.eu/1FrbcHK fi’zi:k shoes and saddles: http://gcn.eu/1tsXI7S and http://gcn.eu/1KxBGd5 Topeak tools: http://gcn.eu/1Lc4HAj Canyon bikes: http://gcn.eu/1Oge4gz Science in Sport: http://gcn.eu/1GrXo6n Orbea bikes: http://gcn.eu/1oks6GH Trek Bicycles: http://gcn.eu/1RUwyGf Vision wheels: http://gcn.eu/1qHTlMu Zipp wheels: http://gcn.eu/1OcMUv5 Powertap: http://gcn.eu/1XlfT2p power2max: http://gcn.eu/1sdoPva Rotor: http://gcn.eu/1q3vtCo Reynolds: http://gcn.eu/1JjCDVL Park Tool: http://gcn.eu/2hcT2Yb Continental tyres: http://gcn.eu/2hcDQdy Camelbak: http://gcn.eu/2h4HzqD YouTube Channel - http://gcn.eu/gcnYT Facebook - http://gcn.eu/gcnFb Google+ - http://gcn.eu/gcnGPlus Twitter - http://gcn.eu/gcnTW Leave us a comment below!