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In this segment from MeritTV, Dr. Sue Decotiis explains why some patients don’t achieve the full fat loss potential of GLP-1 medications like Ozempic and Mounjaro—and what separates the most successful outcomes from the rest. GLP-1 medications like Ozempic, Mounjaro, Wegovy, and Zepbound are popular for weight loss—but new real-world data shows most patients lose far less weight than in clinical trials. In this video, New York City weight loss expert Dr. Sue Decotiis explains why this happens, and what can be done to fix it. Dr. Decotiis reveals why patients often fail to achieve optimal results on GLP-1s: self-prescribing, underdosing, stopping medications early, and failing to measure fat loss instead of just weight. She stresses the importance of medical supervision, proper dosing, hydration, protein intake, and body composition tracking to ensure long-term success. If you're frustrated with your progress on Ozempic, Wegovy, or Mounjaro, this video is a must-watch. Sue Decotiis, MD 20 E 46th St., #1201 NYC, NY 10017 (917) 261-3177 https://www.drdecotiis.com #Ozempic #Mounjaro #Wegovy #Zepbound #GLP1 #Semaglutide #Tirzepatide #WeightLoss #FatLoss #BodyComposition #OzempicResults #GLP1Medications #OzempicTransformation #GLP1Journey #WeightLossDoctor #NYCHealth #MedicalWeightLoss #DrSueDecotiis #WeightLossSupport #HealthNews #MeritTV #News Transcript (Trimmed): Speaker 1: More news that works for your health this morning. And this is a big heads up. GLP-1 weight loss drugs like Ozempic, Wegovy and well, they produce significantly less weight loss than the clinical trials that made them famous. Very interesting. Now this study is from the Journal of Obesity. It shows the average patient lost just 8.7% of their body weight after a year. That's far below the 15 to 21% weight loss reported in the initial clinical trials. Now, the study also tracked nearly 8000 patients by the Cleveland Clinic for severe obesity. It showed that overall, patients had better odds of losing 10% of their body weight after a year staying on the medication. However, that 10% is still below the percentages that were shown. And again, the initial clinical trials. As a follow up study, we know it is in the works to better understand why patients stop taking those GLP-1 drugs. Let's get some more information on this very interesting finding. We want to bring in Dr. Sue Decotiis. And she is a New York City weight loss doctor. Doctor, thank you for joining us. Good morning to you. So why this difference between actual weight loss and weight loss in the clinical trials? Speaker 2: This is such a great question. And I see this every day in my New York City weight loss practice. Patients, a lot of patients are DIYers, right? They're getting the drug from an online platform. Or they may be seeing a physician who's not a medical weight loss specialist. So that really means they're not getting the best care. They might be self dosing. And what happens is that if you're on these weight loss drugs—I'm talking Mounjaro, which is tirzepatide, Ozempic, semaglutide, Wegovy—if you're not losing fat, you're not winning the war. The goal is not just weight loss. It's fat loss. And the physician or the patient is not going to know if that's happening unless the patient is being followed with a body composition scale. So that's why I really think if you're going to spend the money, you really want to get healthy and lose weight, see a medical weight loss specialist. I think that's very important. So what happens is that if you're not losing fat, you know, the drug—you kind of start plateauing and then you start using the drug as an appetite suppressant, which is not really what it's supposed to do. These drugs work by turning on insulin so that you can actually burn fat. So in my practice, my patients actually have lost more weight than the Lilly study, okay, because I'm following them carefully. You have to stay very well hydrated while you're on these medications, sometimes upwards of a gallon a day. It really depends on the individual. And we measure this with our scale. You need to get 100g of protein in. Sometimes in the beginning people aren't hungry and they're not eating at all. And that's terrible. So they really need a lot of supervision. (Watch the full video for more.)
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In the world of medicine and pharmaceuticals, new treatments and medications are constantly being developed to address various health conditions. One area of focus in recent years has been the treatment of obesity and type 2 diabetes, as these conditions continue to be significant public health concerns. Two medications that have garnered attention in this realm are tirzepatide and semaglutide, both of which have shown promise in promoting weight loss in individuals with obesity and type 2 diabetes.

Tirzepatide
Tirzepatide is a novel once-weekly injectable medication that belongs to a class of drugs called dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists. It works by stimulating the release of insulin and inhibiting the release of glucagon, which helps control blood sugar levels. In addition to its effects on blood sugar, tirzepatide has also been shown to promote weight loss by reducing appetite and increasing feelings of fullness.
Studies have demonstrated that tirzepatide can lead to significant weight loss in individuals with obesity and type 2 diabetes. In a clinical trial involving over 1,800 participants, those who received tirzepatide experienced an average weight loss of 12-15% of their body weight over the course of 40 weeks. This weight loss was sustained over a 78-week period, with participants continuing to see improvements in their overall health and well-being.
Overall, tirzepatide has shown promising results in promoting weight loss and improving metabolic health in individuals with obesity and type 2 diabetes. Its dual mechanism of action, targeting both GIP and GLP-1 receptors, makes it a unique and potentially effective treatment option for these conditions.
Semaglutide
Semaglutide is another injectable medication that belongs to the GLP-1 receptor agonist class. It works by stimulating insulin secretion and reducing glucagon production, leading to improved blood sugar control. Like tirzepatide, semaglutide has also been shown to promote weight loss in individuals with obesity and type 2 diabetes through its effects on appetite regulation and energy balance.
In clinical trials, semaglutide has demonstrated significant weight loss effects, with participants experiencing an average weight loss of 10-14% of their body weight over the course of 52 weeks. This weight loss was sustained over a 104-week period, with participants also seeing improvements in their cardiovascular risk factors and overall quality of life.
Overall, semaglutide has proven to be an effective treatment option for individuals with obesity and type 2 diabetes who are looking to lose weight and improve their metabolic health. Its once-weekly dosing schedule and favorable side effect profile make it a convenient and well-tolerated option for many patients.
Comparing Effectiveness in Weight Loss
When comparing tirzepatide and semaglutide in terms of their effectiveness in promoting weight loss, several factors must be taken into consideration. Both medications have been shown to lead to significant weight loss in individuals with obesity and type 2 diabetes, but there are some differences in their mechanisms of action and side effect profiles that may influence treatment decisions.
One key difference between tirzepatide and semaglutide is their dual versus single receptor agonist activity. Tirzepatide targets both GIP and GLP-1 receptors, while semaglutide specifically targets GLP-1 receptors. This dual mechanism of action may provide additional benefits in terms of weight loss and metabolic control, but it may also increase the risk of certain side effects.
In terms of weight loss outcomes, both tirzepatide and semaglutide have been shown to lead to similar amounts of weight loss in clinical trials. However, some studies have suggested that tirzepatide may be more effective in promoting weight loss in certain subpopulations, such as individuals with higher baseline body weight or insulin resistance.
Leanbiome Natural Weight Loss Supplement Does It Really Lose Weight Review 2025
KATIE Price has addressed her drastic weight loss after fans were left concerned for the star. The former glamour model, 46, has been bombarded with messages from fans fearing for her new, slimmer figure. Read more here: https://www.thesun.co.uk/tvandshowbiz/33110364/katie-price-hits-back-skinny-backlash-weight-loss/ The Sun delivers breaking news, latest gossip and incredible exclusives around the world with hubs in London, New York, Scotland and Ireland. Covering topics from news, money and sport along with our famous Fabulous Magazine,The Sun is the biggest newsbrand in the UK and one of the fastest growing news sites in the US. Stay tuned for video clips across the biggest news stories and segments from The Sun’s expert journalists. Become a Sun Subscriber and hit the bell to be the first to know. Read The Sun: https://www.thesun.co.uk/ Like The Sun on Facebook: https://www.facebook.com/thesun/ Follow The Sun on X: https://twitter.com/TheSun Follow The Sun on TikTok: https://www.tiktok.com/@thesun Subscribe to The Sun on Snapchat: https://www.snapchat.com/discover/The_Sun/1633225139 #thesun #katieprice #weightloss #weightlossjourney #ozempic #showbiz #showbiznews #model #uknews
Java Burn The Secret To Fast Weight Loss
In this video, we will be discussing an exciting update on my weight loss journey using the medication Ozempic. I've been on this medication for five months now, and I'm thrilled to share my progress with you. Ozempic is a prescription medication that helps to control blood sugar levels and reduce appetite, leading to weight loss. In this update, I'll be sharing my before and after photos, discussing my overall progress, any challenges I've faced, and how I've managed to stay on track with my weight loss goals. I'll also be sharing tips and advice for anyone considering taking Ozempic or starting their weight loss journey. Whether you're interested in Ozempic specifically or just looking for some inspiration to help you on your weight loss journey, this video is a must-watch!
Fda Approves Eli Lilly's Zepbound Drug For Weight Loss
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Keto Tone on Shark Tank: Does It Live Up to the Hype?
Join my Email List: https://www.thomasdelauer.com Try Perfect Keto's Keto Collagen: http://www.perfectketo.com/td This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. The best way that you can directly support my channel, is by supporting the brands that help make this all possible. Any product that you see on my channel is a product that I also use personally, regardless of any paid promotion. Get my Free Newsletter and Downloadable Cheatsheets (eating out, travel, etc): https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer Questions that will be answered in this video regarding how to properly recover post cardio, with recovery and fat loss in mind: - What food should I eat after cardio? - What supplements should I take post cardio? - How much protein after cardio? - How many carbs after cardio? References https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqaa073/5828186 https://www.ncbi.nlm.nih.gov/pubmed/11255140 https://www.researchgate.net/publication/269041446_Ultra-endurance_exercise_induces_stress_and_inflammation_and_affects_circulating_hematopoietic_progenitor_cell_function https://pubmed.ncbi.nlm.nih.gov/25371101/ https://pubmed.ncbi.nlm.nih.gov/25371101/ https://www.sciencedirect.com/science/article/abs/pii/S0031938418308497 https://onlinelibrary.wiley.com/doi/full/10.1111/apt.14157 https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqaa073/5828186 https://pubmed.ncbi.nlm.nih.gov/10875252/ https://www.ncbi.nlm.nih.gov/pubmed/15946410 https://www.ncbi.nlm.nih.gov/pubmed/22765297 https://www.mdpi.com/2306-5710/3/1/6/htm https://www.ncbi.nlm.nih.gov/pubmed/28778220 https://www.phytochemicals.info/phytochemicals/cyanidin/anti-inflammatory.php https://vivo.health.unm.edu/display/n830076249 https://academic.oup.com/jn/article/144/2/218/4575102 https://pubmed.ncbi.nlm.nih.gov/28935827/ https://pubmed.ncbi.nlm.nih.gov/17614027/ https://www.ncbi.nlm.nih.gov/pubmed/17076983 https://www.ncbi.nlm.nih.gov/pubmed/22486722