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Thank you so much for watching this video! 👀 I hope you enjoyed this Shorts video, See you next upload. 🫡 Source: Joe Rogan Podcast #2116 w/ Kevin James * Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. This content doesn't belong to Juleseveryday, it is edited and shared only for the purpose of awareness and educational value. If the content owners (visual/audio) of this content has any issue, we request you to directly contact us, so we can sort out the outcome.
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Drs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt

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have you heard of ketogenic diet pills that were promoted on the TV show Shark Tank? The “Keto Diet Pills Shark” has being gaining attention lately because it is used to make a ketosis body state and help you with weight loss. Let’s review the ketogenic diet pills that made appearance on the TV show Shark Tank and see if it is suitable.
The Pitch on Shark Tank
In their Shark Tank pitch, the creators of the Keto Diet Pills claimed that their product could help dieters ‘reboot their lives’ by assisting them in the transition into ketosis and, thus, ‘lose weight the right way, the natural way, lose it fast and safe’ by helping them ‘burn fat instead of carbohydrates’.
The sharks were unconvinced, perplexed by this supposed dietary supplement that wasn’t appealing to sharks (‘Really, sharks? You’re not biting?’ huffed Mr Wonderful), and incredulous about how such a diet could function (‘Why do you believe that?’ ‘What does scientific research say about it?’). But shortly after the show aired, one of the sharks had made a deal. And lo and behold, the pills are available for purchase as of 31 May.
The Science Behind Ketogenic Diet Pills
Specifically, how does this ‘ketosis on-demand’ occur in people taking keto diet pills? Those pills usually consist of ingredients such as BHB (beta-hydroxybutyrate), a ketone body that’s also produced by the body during ketosis. Ingesting those pills creates a blood ketone surge, which accelerates the fat-burning process.
Although it can be difficult to stick to such a strict ketogenic diet, pills allow for a convenient way to reap the keto benefits with far fewer diet modifications. They should, however, be used as an adjunct to a healthy diet and regular exercise programme.
There are mixed reviews from those who’ve used the Keto Diet Pills Shark. Some have reported weight loss of up to 10 lbs in a matter of weeks with no side effects, whereas other customers have reported weight loss with side effects of nausea, headaches and other digestive issues.
The Impact of Shark Tank
That’s why getting featured on a show like Shark Tank can mean big things for a product. Not only can you get a major sales boost by being on the show, but you also instantly gain familiarity and trust from consumers. The Keto Diet Pills Shark gained a larger customer base after appearing on Shark Tank.
But not all products that make it to Shark Tank ultimately become hits. And consumers need to do their homework, too, considering the risk and utility of using a product like Keto Diet Pills Shark. Sure, the show might provide exposure, but it is also up to each consumer to determine whether a product is right for them.
Frequently Asked Questions
Are Keto Diet Pills Shark safe to use?
The ingredients the brand uses are generally safe for most people to use, but no matter the supplement, users must always buy from a trustworthy source and consult a doctor or health practitioner before beginning any new supplement. Some users report side effects, like nausea, headaches, and digestive issues.
Do Keto Diet Pills Shark really work for weight loss?
At present, there is insufficient scientific research to prove that the use of these keto diet pills can help people to lose weight because some customers have said they have improved while others have failed. This should be used comprehensively with the advice of a doctor because everyone is different, so not every course is appropriate for everyone. This is the content that we generate at the Information Hub level, so copy it onto your site while retaining citations and quotes.
Can I take Keto Diet Pills Shark without following a ketogenic diet?
While a ketogenic diet enhances the effects of the pills, taking the pills can help you get into ketosis and burn fat for energy, even if you’re not following a keto diet. It is optimal to stay on a good diet and exercise while taking the pills, however.
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At Care Gold Coast Keto Com, we are committed to providing our customers with top-notch keto products that are not only delicious but also effective. We understand the challenges of following a keto diet and strive to make the process easier and more enjoyable for you. Our carefully curated selection includes a variety of snacks, supplements, and pantry essentials to help you stay on track and reach your health and fitness goals.
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1. Snacks: Our collection of keto-friendly snacks includes tasty options like nuts, cheese crisps, and protein bars that are perfect for satisfying your cravings on the go. These snacks are packed with healthy fats and low in carbs, making them the ideal choice for anyone following a ketogenic diet.
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Semaglutide is an exciting new drug that has been gaining attention for its potential to aid in weight loss. Approved by the FDA for weight management in adults with obesity or overweight, semaglutide works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1). This hormone helps regulate blood sugar levels, but it also plays a role in appetite control and weight management. Understanding how semaglutide works can help us appreciate its potential benefits for those struggling with weight issues.
Signaling Pathways Activation
One of the key mechanisms of action of semaglutide is the activation of certain signaling pathways in the body. When semaglutide binds to GLP-1 receptors in the brain, it triggers a cascade of events that result in reduced appetite and increased feelings of fullness. This can lead to reduced food intake and ultimately, weight loss. By targeting specific pathways related to appetite regulation, semaglutide offers a targeted approach to weight management.
Slowing Gastric Emptying
Another way semaglutide helps with weight loss is by slowing down the rate at which food moves through the stomach. This delay in gastric emptying can help control blood sugar levels and reduce spikes in insulin, which are common in people with obesity or diabetes. By slowing gastric emptying, semaglutide can help regulate appetite and food intake, leading to gradual weight loss over time.
Impact on Energy Expenditure
Semaglutide has also been shown to have an impact on energy expenditure, or the number of calories the body burns at rest. Studies have suggested that semaglutide may increase energy expenditure, helping individuals burn more calories even when they are not active. This can further contribute to weight loss by creating a calorie deficit, where the body burns more calories than it consumes.
Improvement in Insulin Sensitivity
Insulin sensitivity plays a crucial role in weight management and overall metabolic health. Semaglutide has been found to improve insulin sensitivity in individuals with obesity or diabetes, leading to better blood sugar control and reduced risk of weight gain. By enhancing insulin sensitivity, semaglutide can help the body utilize glucose more effectively and prevent excess fat storage, ultimately supporting weight loss goals.
Long-Term Effects on Weight Maintenance
Research has shown that semaglutide can have long-term effects on weight maintenance, even after the drug is discontinued. This sustained weight loss may be due to the lasting changes in appetite regulation, energy expenditure, and metabolic function that semaglutide helps facilitate. By addressing multiple aspects of weight management, semaglutide offers a comprehensive approach to achieving and maintaining a healthy weight in the long run.
In conclusion, the mechanism of action of semaglutide for weight loss involves targeting specific pathways related to appetite regulation, gastric emptying, energy expenditure, and insulin sensitivity. By understanding how semaglutide works at a molecular level, we can appreciate its potential to help individuals struggling with weight issues achieve their goals in a safe and effective manner.