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New evidence brings more good news about the unanticipated effects of the GLP-1 receptor agonists. https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt -- TRANSCRIPT -- Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. It’s quite a thing that we live in an era with the biggest blockbuster weight-loss drugs in history, and I can look at you straight-faced and say, yeah, but honestly that’s not the most interesting thing about the GLP-1 receptor agonists such as Ozempic. Beyond their clear utility in weight loss, we have good data that demonstrate the drugs lead to improvements in rates of heart disease, liver disease, and even all-cause mortality, and intriguing reports of strange off-target effects: a reduction in gambling, drinking, drug use, smoking, and compulsive shopping. It’s honestly hard to find an organ system or self-destructive behavior that GLP-1 drugs don’t seem to improve somehow. It’s almost strange. It’s as if the statins came out and everyone was excited about the cholesterol going down, and then we discovered that they reversed hair loss or took three strokes off your golf game. How does one drug do so many things? I think the behavioral changes are the clue. The fact that people may drink or smoke less on these drugs should tell you that something is happening in their brains. And if these drugs are acting on the brain, you might well wonder if they can reduce the risk for brain disease — dementia. And, at least according to a new study, the answer appears to be yes. As the GLP-1 drugs started getting more and more popular, I decided to perform some due diligence and refresh what I had learned in med school about this thing called “glucagon-like peptide.” These drugs bind to the same receptor that GLP does, primarily to cause the pancreas to release more insulin when blood sugar is high. But we have plenty of drugs that stimulate insulin release. And they don’t seem to have all these other weird effects. So, what’s going on? When a drug acts on a specific receptor, it is worth seeing what cells in the body have that receptor, and this is a pretty interesting figure that shows that. You see high expression in the pancreas — no surprise. But next is expression in the heart muscle — interesting, considering these drugs have been shown to reduce the risk for heart disease. Then the salivary glands, and then… the cerebral cortex. The brain. And not just any part of the brain, the thinking part of the brain. A lot happens when these drugs bind to a receptor on a cell. But the brain is a mysterious and important organ. In contrast, the heart is relatively simple, and there are multiple randomized trials that show that GLP-1 drugs, as well as some other drugs for diabetes, such as the SGLT2 inhibitors, pioglitazone, and metformin, reduce the risk for cardiovascular disease in people with diabetes. So, it makes sense to ask whether these drugs would do the same for brain disease. Enter this study, "Cardioprotective Glucose-Lowering Agents and Dementia Risk," from Catriona Reddin and colleagues in JAMA Neurology. It’s an impressive bit of work combining data from 23 different randomized trials of these drugs including more than 150,000 individual people, to determine whether they reduce the risk for dementia. This is the best evidence we have to date for a neuroprotective effect of GLP-1 inhibitors. And this is the only type of study that could give us this evidence. The reason you need to combine so much data to detect a signal is that, to date, no randomized trials of GLP-1 drugs have been designed with dementia as a primary outcome. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt
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Are you following a keto diet and looking for a delicious way to satisfy your sweet tooth? Look no further than keto gummies! These tasty treats are low in carbs, sugar-free, and full of flavor, making them the perfect snack for anyone on a low-carb diet. But where can you find keto gummies in stores? In this shopping guide, we’ll explore the best places to buy keto gummies so you can enjoy them whenever the craving strikes.
Online Retailers
One of the easiest ways to find keto gummies is to shop online. Many retailers specialize in low-carb and keto-friendly products, making it simple to find a wide variety of gummies to choose from. Simply browse the selection, add your favorites to your cart, and have them shipped right to your door.
Popular online retailers like Amazon, Thrive Market, and Netrition offer a wide variety of keto gummies to choose from. You can find everything from traditional gummy bears to more unique flavors like peach rings and sour worms. Plus, many online retailers offer subscription options so you can have your favorite keto gummies delivered on a regular basis.
If you’re looking for a specific brand of keto gummies, be sure to check the manufacturer’s website. Many brands sell their products directly to consumers online, making it easy to stock up on your favorite snacks without leaving the comfort of your home.
Health Food Stores
Another great place to find keto gummies is at your local health food store. These stores often carry a selection of low-carb and keto-friendly snacks, including gummy candies. Simply visit the candy aisle or ask a store associate for help finding the keto gummies section.
Popular health food stores like Whole Foods, Sprouts, and Natural Grocers are great places to start your search for keto gummies. These stores prioritize quality ingredients and often carry a variety of low-carb options for health-conscious shoppers.
When shopping at a health food store, be sure to check the nutrition label on any gummy candies you’re interested in. Look for products that are low in net carbs and sugar-free to ensure they fit within your keto diet plan.
Specialty Shops
If you’re looking for a more specialized selection of keto gummies, consider visiting a specialty shop. These stores cater to specific dietary needs and may carry a wider variety of low-carb and sugar-free snacks, including gummy candies.
Keto specialty shops like The Keto Box and The Low Carb Grocery are great places to find unique and hard-to-find keto snacks, including gummies. These shops often curate boxes of keto-friendly products, making it easy to discover new brands and flavors.
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When shopping at a specialty shop, be prepared to pay a premium for high-quality keto gummies. These products are often made with premium ingredients and may be more expensive than mass-produced options.
Local Farmers’ Markets
For a more local and artisanal option, consider visiting your nearest farmers’ market. Many vendors at farmers’ markets create their own keto-friendly snacks, including gummy candies. Take a stroll through the market and look for vendors selling homemade gummies made with natural ingredients.
When shopping at a farmers’ market, be sure to ask vendors about the ingredients used in their gummies. Look for products that are made with real fruit juice, natural sweeteners, and other keto-friendly ingredients to ensure you’re getting a high-quality product.
Supporting local vendors at farmers’ markets is a great way to discover unique and delicious keto gummies while also supporting small businesses in your community.
Big Box Retailers
You might be surprised to find keto gummies at your favorite big-box retailer. Stores like Walmart, Target, and Costco often carry a selection of low-carb and sugar-free snacks, including gummy candies. Simply visit the candy aisle or check the health food section for keto-friendly options.
Shopping for keto gummies at big-box retailers can be a convenient and budget-friendly option. You can stock up on your favorite snacks while doing your regular grocery shopping, making it easy to stay on track with your low-carb diet.
When shopping at a big-box retailer, be sure to compare prices and check the nutrition labels on different brands of keto gummies. Look for products that are low in carbs, sugar-free, and made with natural ingredients for the best quality.
No matter where you choose to shop for keto gummies, be sure to read the nutrition label carefully and choose products that fit within your dietary preferences and restrictions. With so many options available, you’re sure to find the perfect keto gummies to satisfy your cravings and keep you on track with your low-carb lifestyle.
Summary
In conclusion, keto gummies are a delicious and convenient way to enjoy a sweet treat while following a low-carb diet. Whether you prefer to shop online, visit health food stores, explore specialty shops, browse farmers’ markets, or check out big-box retailers, there are plenty of options for finding keto gummies in stores. Just be sure to read the nutrition labels, choose products that fit within your dietary needs, and enjoy these tasty snacks in moderation. With a little bit of searching, you’ll be well on your way to satisfying your sweet cravings the keto-friendly way!
If you have any questions about where to find keto gummies in stores or need recommendations for specific brands or flavors, check out our FAQ section below. We’re here to help you discover the best options for satisfying your sweet tooth while sticking to your low-carb diet plan.
