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🚀 Stay ahead in combination products, pharma, and medical devices 👉 https://www.letscombinate.com 🎙️ Listen to more expert discussions on regulations, drug delivery, and quality 👉 https://www.letscombinate.com/ Get expert insights on FDA regulations, risk management, quality systems, and the latest trends in drug-device combination products. Ben Locwin discusses the science, quality, and future of GLP-1 receptor agonists, revolutionary drugs used in diabetes and obesity treatment. The episode explores the history and development of GLP-1s, their commercial viability, manufacturing challenges, and regulatory landscapes. Ben dives into the mechanisms of GLP-1s, including their influence on appetite, blood sugar, and gastrointestinal effects. They also touch on the capacity issues in production, the impact of compounding, and the sustainability concerns associated with injector pens. The conversation provides an in-depth look at the pharmaceutical industry’s response to the surge in GLP-1 demand, highlighting the broader implications for patient care and market trends. 00:00 Introduction to GLP Receptor Agonists 00:46 Guest Introduction: Ben Locwin 01:48 Historical Context of GLP-1 Development 05:54 Mechanisms and Effects of GLP-1 09:51 Market Impact and Manufacturing Challenges 11:16 Regulatory and Advertising Considerations 17:44 Sustainability and Injector Pen Issues 19:40 Risk Management and Future Directions 23:31 Conclusion Ben Locwin is a Healthcare Executive, MMA fighter, Jiu Jtisu pro and Quality and Regulatory SME working in medical devices, pharma and other regulated industries. Subhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee. For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

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Virginia is a pharmacist registered with the GPhC (General Pharmaceutical Council) in the UK and this channel is for informational purposes only. The information presented is accurate to the best of Virginia's knowledge. You are responsible for your own research and application of the information presented. Please see a healthcare professional such as a pharmacist, doctor or nurse as appropriate for your own health needs. No promotions. Just health education.How To Lose Weight And Keep Your Curves

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GLP1 agonists (GLP1a), including semaglutide and tirzepatide, were initially developed for diabetes mellitus (DM) management but are increasingly used for obesity. Female factor infertility has been found to improve after exposure to GLP1a, though it is unclear if the effect is related to obesity or other drug effects. The impact of GLP1a on male factor infertility has not been fully described. This study sought to assess improvements in semen analysis (SA) parameters in men with abnormal SA, while controlling for DM and body mass index (BMI), to determine the improvement attributable to GLP1a exposure. Read the full abstract: https://www.auajournals.org/doi/10.1097/01.JU.0001110004.96669.db.06

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https://teambodyproject.com Transform your body in just 10 weeks and take part in the entire Body Project system! Or simply come and join the conversation at http://www.facebook.com/bodyprojectsocial In this advanced cardio interval workout, we take you through a number of 60 second exercise intervals with 30 second rest periods. This Body Project cardio exercise routine is designed to maximise calories burnt and optimise fat burning. The workout includes a number of bodyweight exercises that work the legs, abs, glutes and upper body. This is a great way to workout from home with no equipment needed.