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Ozempic or Mounjaro – Which One is Right for You? Both Ozempic and Mounjaro are powerful tools for managing type 2 diabetes, weight loss, and even heart and kidney health—but are they the same? Not quite! In our latest episode, Dr. Steve Edelman and Dr. Jeremy Pettus break down the key differences, from how they work in the body to real-world results in A1C reduction, weight loss, and beyond. Plus, they dive into the latest research on additional benefits, accessibility challenges, and what patients need to know when choosing between the two. Have you tried either of these medications? What was your experience like? Drop your thoughts in the comments! Curious about how they compare? We break it all down in our latest video: https://bit.ly/4j4h0RE

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This is the second lecture on the management of type 2 diabetes. It focuses on the use of GLP-1 RA, DPP4 inhibitor and SGLT2 inhibitors. The unique advantages of these newer agents and their exact place in the management of diabetes is highlighted.

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Eli Lilly announced promising clinical trial results for orforglipron, a daily pill that could rival the effectiveness of injectable GLP-1 drugs like Ozempic and Mounjaro for type 2 diabetes and weight loss. This new oral medication demonstrated similar reductions in blood sugar and comparable weight loss to the injectables in a 40-week study. Unlike existing GLP-1s that require refrigeration and injection, orforglipron offers the convenience of a pill, potentially increasing its accessibility. While Eli Lilly anticipates seeking regulatory approval soon and analysts predict it will be a blockbuster, the drug's pricing and global accessibility remain key questions. The development of this non-peptide oral GLP-1 represents a significant advancement in pharmaceutical chemistry and could transform treatment options for millions.

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The 2024 Lasker–DeBakey Clinical Medical Research Award has been presented for the discovery of GLP-1 and its application to the treatment of obesity. Lasker winner Svetlana Mojsov, PhD, discusses her role in this innovative discovery and more with JAMA Senior Editor Anne Rentoumis Cappola, MD, ScM. Related Content: Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.17571?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.17873?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public GLP-1 for Treating Obesity—Origin, History, and Evolution https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.18000?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public AIDS in Africa—Impact of Research https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.18271?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public Podcast was originally published on September 19, 2024. https://edhub.ama-assn.org/jn-learning/audio-player/10.1001/jama.2024.18624?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public --------------------------------------------------------------------------------- Follow JAMA Author Interviews on: Youtube: https://www.youtube.com/playlist?list=PL4VOPuLXRs1dWJCIIu2iOIOWRGUc0nTOU Apple Podcasts: https://podcasts.apple.com/us/podcast/jama-author-interviews-covering/id410339697 Spotify: https://open.spotify.com/show/61HE3v2dmxyg3nsIRAK25C?si=bcbb384405d44b71 Pocket Casts: https://pca.st/DAh2 Your podcast app of choice: https://pod.link/410339697 Website: https://jamanetwork.com/journals/jama/pages/jama-author-interviews --------------------------------------------------------------------------------- For more from JAMA • https://www.jama.com • https://www.facebook.com/JAMAJournal • https://www.twitter.com/JAMA_Current • https://www.linkedin.com/company/jamanetwork Follow the JAMA Network • https://www.jamanetwork.com • http://www.jamanetworkaudio.com • https://www.facebook.com/JAMANetwork • https://www.twitter.com/JAMANetwork • https://www.instagram.com/JAMANetwork • https://www.pinterest.com/JAMANetwork