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In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity." We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways. First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose. Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings. #HubermanLab #Science Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman Levels: https://levels.link/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network Dr. Peter Attia Website: https://peterattiamd.com Outlive: The Science & Art of Longevity: https://peterattiamd.com/outlive The Peter Attia Drive Podcast: https://peterattiamd.com/podcast Newsletter: https://peterattiamd.com/newsletter X (formerly Twitter): https://twitter.com/PeterAttiaMD Instagram: https://www.instagram.com/peterattiamd YouTube: https://www.youtube.com/c/PeterAttiaMD Facebook: https://www.facebook.com/peterattiamd Articles Reassessing the evidence of a survival advantage in Type 2 diabetes treated with metformin compared with controls without diabetes: a retrospective cohort study: https://bit.ly/3EypTAJ The Hallmarks of Aging: https://bit.ly/3ZeqnFI Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls: https://bit.ly/3Lespjp A thalamic circuit represents dose-like responses induced by nicotine-related beliefs in human smokers: https://bit.ly/3LiAaEX Other Resources TAME (Targeting Aging with Metformin) Trial: https://bit.ly/3P7eMDI Interventions Testing Program (ITP): https://bit.ly/3EDtmOg Slow-Carb Diet (Tim Ferris): https://bit.ly/462q6YD Dr. Alia Crum: Science of Mindsets for Health & Performance (Huberman Lab episode): https://bit.ly/3PdbKhd Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping (Huberman Lab episode): https://bit.ly/3PkGopc Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects (Huberman Lab episode): https://bit.ly/3Pg7jT3 Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: an argument for multiple comparisons correction (Dead salmon study): https://bit.ly/3PvJvf9 Timestamps 00:00:00 Dr. Peter Attia, Journal Club 00:03:27 Sponsors: Helix Sleep & Levels 00:06:11 Dreams 00:12:36 Article #1, Metformin, Mitochondria, Blood Glucose 00:19:47 Type 2 Diabetes & Causes, Insulin Resistance 00:25:30 Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study 00:36:19 Sponsor: AG1 00:37:15 TAME Trial; Demographics, Twin Cohort 00:44:27 Metformin & Mortality Rate 00:51:28 Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power 01:01:17 Sponsor: InsideTracker 01:02:23 Hazard Ratios, Censoring 01:09:00 Metformin Advantage?, Variables, Interventions Testing Program 01:16:02 Berberine, Acarbose, SGLT2 Inhibitors 01:23:48 Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers 01:32:22 Tool: Reading Journal Articles, 4 Questions, Supplemental Information 01:38:10 Article #2, Belief Effects vs. Placebo Effect 01:45:22 Nicotine Effects 01:51:07 Nicotine Doses & Belief Effects, fMRI Scan 02:00:07 Biological Effects, Dose-Dependent Response & Belief Effects 02:05:14 Biology & Beliefs, Significance, Dopamine Response, Non-Smokers 02:10:57 Dose-Dependence & Beliefs, Side Effects, Nocebo Effect 02:19:06 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://hubermanlab.com/disclaimer
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Abnehmen ist ein häufiges Ziel vieler Menschen, die ihren Körper in Form bringen wollen. Es gibt unzählige Diäten, Tipps und Tricks, die versprechen, schnell und effektiv Gewicht zu verlieren. Doch was sind die Grundlagen für eine effektive Gewichtsabnahme und wie kann man dieses Ziel langfristig erreichen?
Grundlagen für eine effektive Gewichtsabnahme
Um effektiv abzunehmen, ist es wichtig, ein Kaloriendefizit zu erreichen. Das bedeutet, dass man mehr Kalorien verbrennen muss, als man zu sich nimmt. Dies kann durch eine Kombination aus gesunder Ernährung und regelmäßiger Bewegung erreicht werden. Es ist wichtig, auf eine ausgewogene Ernährung zu achten, die alle wichtigen Nährstoffe enthält. Dazu gehört eine ausreichende Menge an Obst, Gemüse, Vollkornprodukten, magerem Eiweiß und gesunden Fetten.
Regelmäßige Bewegung spielt ebenfalls eine wichtige Rolle beim Abnehmen. Ausdauersportarten wie Laufen, Schwimmen oder Radfahren unterstützen den Kalorienverbrauch und helfen dabei, Fett zu verbrennen. Auch Krafttraining ist wichtig, um Muskeln aufzubauen und den Stoffwechsel zu erhöhen. Je mehr Muskeln man hat, desto mehr Kalorien verbrennt der Körper, selbst im Ruhezustand.
Eine ausreichende Flüssigkeitszufuhr ist ebenfalls entscheidend für eine effektive Gewichtsabnahme. Wasser hilft dabei, den Stoffwechsel anzukurbeln, Giftstoffe aus dem Körper zu spülen und das Sättigungsgefühl zu unterstützen. Es wird empfohlen, mindestens 2-3 Liter Wasser pro Tag zu trinken, um den Körper optimal zu unterstützen.
Tipp 1: Mahlzeiten planen und vorbereiten
Um einer ungesunden Ernährung vorzubeugen, ist es ratsam, Mahlzeiten im Voraus zu planen und vorzubereiten. So vermeidet man spontanes Essen von ungesunden Snacks und ist besser in der Lage, gesunde Entscheidungen zu treffen. Außerdem hilft es, Portionsgrößen im Blick zu behalten und Überessen zu vermeiden.
Ein weiterer Tipp ist, die eigenen Essgewohnheiten zu überdenken und bewusst zu genießen. Oftmals essen wir aus Langeweile, Stress oder Gewohnheit, ohne wirklich hungrig zu sein. Indem man sich bewusst auf das Essen konzentriert und langsamer isst, kann man besser auf sein Sättigungsgefühl hören und unnötiges Überessen vermeiden.
Zusätzlich kann es hilfreich sein, einen Ernährungsplan zu erstellen, der auf die eigenen Bedürfnisse und Ziele zugeschnitten ist. Ein Ernährungsberater oder Coach kann dabei unterstützen und individuelle Tipps geben, wie man effektiv abnehmen kann.
Tipp 2: Stress reduzieren und ausreichend schlafen
Stress kann sich negativ auf unser Essverhalten auswirken und dazu führen, dass wir vermehrt zu ungesunden Lebensmitteln greifen. Es ist daher wichtig, Stressquellen zu identifizieren und Strategien zu entwickeln, um Stress zu reduzieren. Dies kann durch Entspannungstechniken wie Yoga, Meditation oder Sport erreicht werden.
Des Weiteren spielt ausreichender Schlaf eine wichtige Rolle beim Abnehmen. Studien haben gezeigt, dass Schlafmangel den Stoffwechsel verlangsamen und das Hungergefühl erhöhen kann. Es wird empfohlen, mindestens 7-8 Stunden Schlaf pro Nacht zu bekommen, um den Körper optimal zu unterstützen und die Gewichtsabnahme zu fördern.
Ein einfacher Tipp, um besser abnehmen zu können, ist das regelmäßige Wiegen. Es hilft, den Fortschritt im Auge zu behalten und motiviert, am Ziel dranzubleiben. Es ist wichtig, jedoch nicht obsessiv zu wiegen und auch andere Fortschritte wie die Verbesserung des Körpergefühls oder der Fitness im Auge zu behalten.
Zusammenfassung
Effektiv abnehmen erfordert eine Kombination aus gesunder Ernährung, regelmäßiger Bewegung, ausreichender Flüssigkeitszufuhr, Stressreduzierung und ausreichend Schlaf. Indem man die Grundlagen einer erfolgreichen Gewichtsabnahme beachtet und Tipps zur Umsetzung nutzt, kann man langfristig erfolgreich abnehmen und das Wunschgewicht erreichen. Es ist wichtig, geduldig zu bleiben und sich kleine Ziele zu setzen, um motiviert zu bleiben und den Prozess zu genießen.
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The ketogenic diet has gained widespread popularity in recent years for its effectiveness in helping people lose weight and improve their overall health. By reducing carbohydrates and increasing fats in the diet, the body is forced to burn fat for energy instead of glucose, leading to rapid weight loss. However, sticking to a strict keto diet can be challenging for many people. That’s where keto supplements like Keto ACV Gummies come in to play.
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Keto ACV Gummies combine the benefits of the keto diet with the powerful effects of apple cider vinegar (ACV) to help you achieve your weight loss goals faster. These gummies are a convenient and delicious way to support your keto journey and boost your metabolism. Made with all-natural ingredients, including organic apple cider vinegar, these gummies are a safe and effective way to enhance your weight loss efforts.
One of the key ingredients in Keto ACV Gummies is apple cider vinegar, which has been shown to have numerous health benefits. ACV is known for its ability to aid in weight loss by reducing appetite, increasing metabolism, and improving digestion. Additionally, ACV can help regulate blood sugar levels and reduce cholesterol, making it a powerful ally in the fight against obesity and metabolic disorders.
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When you take Keto ACV Gummies, the ingredients work together to promote ketosis in the body. Ketosis is a metabolic state in which the body burns fat for fuel instead of carbohydrates, leading to rapid weight loss. By providing your body with exogenous ketones and apple cider vinegar, these gummies help jumpstart the ketosis process and keep you in fat-burning mode.
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There are several benefits to incorporating Keto ACV Gummies into your daily routine. Not only can these gummies help you lose weight faster and more efficiently, but they can also improve your overall health. By supporting ketosis, metabolism, and digestion, these gummies are a powerful tool for anyone looking to achieve their weight loss goals and improve their well-being.
Some additional benefits of Keto ACV Gummies include increased energy levels, reduced cravings, and improved mental clarity. By providing your body with the nutrients it needs to thrive on a keto diet, these gummies can help you feel your best and stay on track with your weight loss journey. Plus, the delicious taste of these gummies makes them a convenient and enjoyable way to supplement your diet.
FAQs About Keto ACV Gummies
1. Are Keto ACV Gummies safe to use?
Yes, Keto ACV Gummies are made with all-natural ingredients and are safe for most people to use. However, if you have any underlying health conditions or are taking medication, it’s always best to consult with your healthcare provider before adding any new supplements to your routine.
2. How many gummies should I take each day?
The recommended dosage of Keto ACV Gummies may vary depending on your individual needs and goals. It’s best to follow the instructions on the product label or consult with a healthcare professional for personalized advice.
3. How long does it take to see results with Keto ACV Gummies?
Results may vary for each individual, but many people report seeing noticeable changes in their weight and overall health within a few weeks of using Keto ACV Gummies consistently. To maximize results, be sure to pair these gummies with a balanced diet and regular exercise.
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