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REFERENCE for Curious Interested Listeners & Physicians 48,25mar In Part 2 of our deep dive into Mounjaro vs. Ozempic, we’re busting myths and uncovering what doctors aren’t always saying. Here’s what we’ll cover: • Myth 1: “All GLP-1 drugs are the same.” • Reality: Ozempic targets a single pathway, while Mounjaro works on two—leading to potential greater weight loss in some, but it’s not a one-size-fits-all. • Myth 2: “These drugs only make you eat less.” • Reality: They also influence the brain’s reward system, reducing cravings and the emotional drivers of eating, not just physical hunger. We’ll break down how these medications work, the real-world impact, and why individual responses vary. Stay tuned Part 3 for more insights into what doctors might not be telling you about these weight loss treatments! 1. Animal Studies Alhadeff AL, Rupprecht LE, Hayes MR. (2012). Glucagon-like peptide-1 receptor signaling in the ventral tegmental area attenuates food intake. Journal of Neuroscience, 32(25), 8112-8120. Showed GLP-1 drugs reduce food-seeking behavior by acting on brain reward areas. 2. Brain Reward Pathways Dickson SL, Shirazi RH, Hansson C, et al. (2012). The role of GLP‑1 receptor activation in the central regulation of energy balance and reward. Physiology & Behavior, 106(2), 231–238. Explains how GLP-1 receptors in the brain influence eating for pleasure, not just hunger. 3. Incretin Hormones Review Nauck MA & Meier JJ. (2018). Incretin hormones: Their role in health and disease. Diabetes, Obesity and Metabolism. Details the dual role of GLP-1 in gut and brain signaling. 4. The SURPASS-2 Trial Jastreboff, A. M., et al. (2022). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2): A Randomized, Open-Label, Parallel-Group, Phase 3 Trial. This study and provided weight loss data for both tirzepatide (Mounjaro) and semaglutide (Ozempic). 5. The SURPASS Clinical Trials (Review and Meta-Analysis) Frías, J. P., et al. (2022). Insights from the SURPASS Clinical Trials: A Systematic Review and Meta-Analysis of Tirzepatide in Type 2 Diabetes. Diabetes, Obesity and Metabolism. Discusses how the additional GIP receptor activity might contribute to enhanced weight loss. 6. Eli Lilly (Mounjaro) https://www.lilly.com/news/media/media-kits/mounjaro https://mounjaro.lilly.com 7. Novo Nordisk (Ozempic) https://www.novonordisk.com.au/our-products-for-healthcare-professionals.html https://rss.medsinfo.com.au/no/pi.cfm?product=nopozemp

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Obesity is a significant health problem affecting millions of people worldwide. It can lead to various health issues such as heart disease, diabetes, and high blood pressure. Many individuals struggling with obesity have tried countless diets, exercise routines, and weight loss medications without much success. However, there is new hope on the horizon with the combination of two powerful weight loss medications, Semaglutide and Phentermine.

The Power of Semaglutide and Phentermine

Semaglutide is a GLP-1 receptor agonist prescribed for the treatment of type 2 diabetes. It works by decreasing appetite and reducing food intake, leading to weight loss. Phentermine, on the other hand, is a stimulant that suppresses appetite and boosts metabolism. When combined, these two medications work synergistically to aid in weight loss.

Studies have shown that individuals using Semaglutide and Phentermine together can achieve greater weight loss compared to using either medication alone. The combination helps control cravings, reduce calorie intake, and increase energy expenditure, making it easier to stick to a healthy diet and exercise regimen.

Before starting Semaglutide and Phentermine, it is essential to consult with a healthcare provider to determine if this combination is right for you. Your doctor will evaluate your overall health, medical history, and weight loss goals to create a personalized treatment plan. They will also monitor your progress and adjust the dosage as needed to ensure optimal results.

Potential Side Effects and Considerations

Like any medication, Semaglutide and Phentermine can cause side effects. Common side effects of Semaglutide include nausea, diarrhea, and constipation, while Phentermine may cause dry mouth, insomnia, and dizziness. These side effects are usually mild and temporary, but it is essential to notify your doctor if you experience any unusual symptoms.

It is also crucial to follow a healthy diet and exercise regularly while using Semaglutide and Phentermine. These medications are not a magic bullet for weight loss and should be used in conjunction with lifestyle changes for long-term success. Maintaining a balanced diet, staying active, and getting enough sleep are essential for reaching and maintaining a healthy weight.

Furthermore, Semaglutide and Phentermine should not be used by pregnant women, individuals with a history of cardiovascular disease, or those with certain medical conditions. It is vital to disclose your complete medical history to your healthcare provider before starting this weight loss regimen to avoid any potential complications.

Conclusion

Using Semaglutide and Phentermine together can be an effective weight loss strategy for individuals struggling with obesity. These medications work in tandem to suppress appetite, increase metabolism, and promote healthy weight loss. However, it is essential to consult with a healthcare provider, follow a healthy lifestyle, and monitor for any potential side effects while using this combination.





By incorporating Semaglutide and Phentermine into a comprehensive weight loss plan, individuals can achieve significant results and improve their overall health and well-being. With the right support and guidance, successful weight loss is within reach for those looking to take control of their health and transform their lives.

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