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David Ricks and Dr. Fatima Cody Stanford talk through the groundbreaking role of GLP-1 medications in transforming the treatment of obesity, and how they might reshape the future of health care, in this interview with Andrew Ross Sorkin at the 2024 New York Times DealBook Summit. Interviewer: Andrew Ross Sorkin, the founder and editor at large of DealBook Guests: David Ricks, the chair and C.E.O. of Eli Lilly and Company, and Fatima Cody Stanford, M.D., M.P.H., M.P.A., M.B.A. an obesity medicine physician at Massachusetts General Hospital/Harvard Medical School
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In continuation of my update "Metformin" GLP-1 receptor agonists, a class of drug used to treat type 2 diabetes, likely trump the widely prescribed metformin for curbing dementia risk in people with the condition, finds the largest study of its kind, published in the open access journal BMJ Open Diabetes Research & Care. The findings suggest that future clinical guidelines for the treatment of type 2 diabetes would do well to consider prioritizing drugs with both blood glucose and neuroprotective effects, say the researchers. Published research suggests that both GLP-1 receptor agonists and metformin, which are widely used to treat type 2 diabetes, protect the brains of people with the disease. But as yet there have been no direct real-world comparisons of the potential impact of these drugs on dementia risk—a risk that is around 70% higher in people with type 2 diabetes. To explore this further, the researchers drew on anonymized electronic health records from a global health research network (Trinetx) spanning the period 2004 to 2024 to track the development of dementia in patients with type 2 diabetes, treated with either GLP-1 receptor agonists or metformin (87,229 patients in each group; average age 58) for at least six consecutive months. There was no significant difference in vascular dementia risk between the two types of drug when used as first line therapy. But GLP-1 receptor agonist use was associated with a significantly lower cumulative (10%) risk of developing dementia, overall, with an incidence of almost 2.5% (2,130 people) compared with an incidence of nearly 5% (4,215 people) for metformin. And specifically, taking this type of drug was associated with a 12% lower risk of developing Alzheimer's disease, and a 25% lower risk of developing non-vascular dementias than metformin use. Further in-depth analyses showed that these positive effects were evident across all age groups, but with the strongest effect among the over 60s, women, and those of white ethnicity. Risk of death from any cause was also lower: nearly 5% of those treated with GLP-1 receptor agonists died compared with nearly 9% of those treated with metformin. "Both medications demonstrate neuroprotective properties, such as reducing neuroinflammation and oxidative stress, improving insulin sensitivity, and enhancing cerebrovascular health, which likely contribute to their benefits in overall dementia," explain the researchers. But unlike metformin, whose benefits primarily derive from systemic metabolic effects, GLP-1 receptor agonists exert direct central nervous system effects by crossing the blood-brain barrier, they add. "However, the multifactorial nature of [vascular dementia], driven by cerebrovascular damage, such as small vessel disease and white matter lesions, poses significant challenges for pharmacological interventions targeting metabolic or neurodegenerative pathways," they continue. This is an observational study, and as such, no firm conclusions can be drawn about cause and effect. And the researchers point out that the tracking period, while sufficient for observing dementia outcomes, may not fully capture long-term cognitive effects, especially given the progressive nature of Alzheimer's disease. REF:https://www.med-chemist.com/2025/07/glp-1-diabetes-drugs-likely-trump.html
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Welcome to Kickin Keto Com, the ultimate resource for everything you need to know about the popular ketogenic diet. Whether you’re just starting out on your keto journey or you’re a seasoned pro looking for new recipes and tips, Kickin Keto Com has you covered. Our team of experts has created a comprehensive website that is jam-packed with information on all things keto, from what to eat and how to meal prep to the science behind why the keto diet works. We are here to support you every step of the way as you work towards achieving your health and wellness goals.
Benefits of the Keto Diet
The keto diet has gained popularity in recent years for its ability to help people lose weight, improve their energy levels, and even potentially reduce their risk of certain diseases. By following a ketogenic diet, which is high in fat, moderate in protein, and low in carbohydrates, your body enters a state of ketosis where it burns fat for fuel instead of glucose. This can lead to rapid weight loss and a decrease in hunger and cravings.
Another benefit of the keto diet is its potential to improve mental clarity and focus. Many people report feeling more alert and productive when they are in ketosis, which can be especially helpful for those with demanding work schedules or busy lives. Additionally, the keto diet has been shown to have anti-inflammatory effects, which can help reduce the risk of chronic diseases such as diabetes and heart disease.
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One of the keys to success on the keto diet is knowing which foods you can eat and which ones to avoid. Keto-friendly foods include things like meat, fish, eggs, cheese, nuts, seeds, and low-carb vegetables. These foods are high in fat and protein and low in carbohydrates, making them perfect for the keto diet. On the other hand, you’ll want to steer clear of foods like bread, pasta, rice, and sugary treats, as these are high in carbs and can kick you out of ketosis.
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Meal planning is essential when following the keto diet, so it’s important to have a variety of keto-friendly foods on hand at all times. This can help you stay on track and avoid temptation when hunger strikes. With a bit of creativity and some meal prep, you can enjoy delicious and satisfying meals while still sticking to your keto goals.
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Meal planning is a crucial aspect of the keto diet, as it can help you stay on track and avoid making unhealthy food choices. Whether you’re meal prepping for the week ahead or looking for quick and easy keto-friendly recipes, Kickin Keto Com has you covered. Our website is full of delicious meal ideas, from hearty breakfasts and satisfying lunches to decadent dinners and indulgent desserts.
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Some popular keto meal ideas include avocado and bacon omelettes, zucchini noodle stir-fry, and cauliflower crust pizza. These meals are not only delicious but also easy to make and incredibly satisfying. With a bit of creativity and some inspiration from Kickin Keto Com, you’ll never run out of tasty keto meal ideas to try.
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Staying motivated on the keto diet can be challenging, especially when you’re first starting out or hitting a plateau in your weight loss journey. That’s where Kickin Keto Com comes in. Our website is full of motivational resources, success stories, and tips for staying on track with your keto goals. We understand that everyone’s journey is unique, and we’re here to support you every step of the way.
One way to stay motivated on the keto diet is to set realistic and achievable goals for yourself. Whether you want to lose a certain amount of weight, improve your energy levels, or simply feel better in your body, having a clear goal in mind can help keep you focused and motivated. It’s also important to celebrate your successes along the way, no matter how small they may seem.
Don’t forget to reach out to the keto community for support as well. Whether it’s joining a keto Facebook group, following keto influencers on social media, or attending keto meetups in your area, connecting with others who are on the same journey can help keep you motivated and inspired. Remember, you’re not alone on your keto journey, and Kickin Keto Com is here to help you every step of the way.
Conclusion
In conclusion, Kickin Keto Com is the ultimate resource for everything you need to know about the keto diet. From the benefits of the keto diet to keto-friendly foods, meal planning and recipes, and staying motivated on the keto diet, our website has you covered. Whether you’re a beginner just starting out or a seasoned pro looking for new inspiration, Kickin Keto Com has something for everyone. We are here to support you on your keto journey and help you achieve your health and wellness goals. So what are you waiting for? Dive in and start exploring all that Kickin Keto Com has to offer!
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Amy Hudson and Dr. James Fisher chat with Dr. Wayne Westcott, an accomplished international expert in health, fitness and aging. He’s the author of over 25 fitness books and the go-to expert and deep source of knowledge for maintaining strength at any age. They discuss how strength training not only combats muscle and bone loss but also helps prevent obesity, type 2 diabetes, and other chronic conditions. Tune in to hear how you can age gracefully and improve your overall health by focusing on strength, muscle retention, and longevity. ● How strength training enhances athletic performance. ● How your kids can benefit academically and cognitively from strength training. ● Learn how strength training prevents muscle loss and fights chronic diseases. ● Ways maintaining muscle keeps your metabolism running efficiently. ● Weight loss should focus on fat reduction, not muscle loss. ● The benefits of extra protein for muscle retention as we age. ● Strength training for postmenopausal health. ● How cutting calories alone leads to unhealthy muscle loss. ● Slower, controlled reps lead to better results with strength training. ● How training 20 minutes twice a week restores muscle and fights aging. ● Ways strength training builds functional muscle for lifelong strength. The Exercise Coach - Get 2 Free Sessions! - http://exercisecoach.com Strength Training Past 50 by Wayne Westcott and Thomas R. Baechle - https://a.co/d/9MVCRY2 Building Strength and Stamina by Wayne Westcott - https://a.co/d/ht7716r This podcast and blog are provided to you for entertainment and informational purposes only. By accessing either, you agree that neither constitute medical advice nor should they be substituted for professional medical advice or care. Use of this podcast or blog to treat any medical condition is strictly prohibited. Consult your physician for any medical condition you may be having. In no event will any podcast or blog hosts, guests, or contributors, Exercise Coach USA, LLC, Gymbot LLC, any subsidiaries or affiliates of same, or any of their respective directors, officers, employees, or agents, be responsible for any injury, loss, or damage to you or others due to any podcast or blog content. 00:00 Start 01:39 Dr. Wescott’s Interest in Resistance Training 04:15 The Most Important Health Benefit of Resistance Training 08:24 How to Lose Weight Without Losing Muscle 13:09 Understand That Successful Weight Loss Involves Maintaining Muscle 15:25 Why Experts Don’t Recommend Cardio For Losing Fat 20:47 Training Recommendations for The General Population 24:46 Repetitions and Time Under Load 29:35 The Future of Strength Training 34:10 Can Strength Training Reverse Aging? 38:24 Parting Thoughts #strengthtraining #healthyaging #balance
