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A new study from The Lancet revealed that three-quarters of U.S. adults and almost half of teens are now overweight or obese. Weight loss drugs like Ozempic, Wegovy, and Mounjaro, known as GLP-1 drugs, have been making headlines as effective treatments that are in high demand. But should they be available to anyone who wants them or only when medically indicated? Those who believe they should be broadly available say they can increase self-esteem and are an important tool for those unable to lose weight through lifestyle changes alone. They also say they may reduce the risks of diabetes, heart disease, and joint issues and point to new research that suggests the drugs might help with improving cardiovascular and brain health and reduce the risk of conditions such as Alzheimer’s disease. Others argue that weight loss drugs are not right for everyone and caution against liberal access, citing both known side effects and unknown long-term effects. They also worry about what could happen if people take them without medical supervision and raise equity issues, given the high cost of the drugs. With this background, we debate whether prescription weight loss drugs should be available for all. Arguing Yes: David Allison, Obesity Researcher; Dean and Distinguished Professor at the Indiana University School of Public Health-Bloomington Arguing No: Stuart W. Flint, Associate Professor of the Psychology of Obesity at the University of Leeds Emmy award-winning journalist John Donvan moderates #weightloss #weightlossjourney #weightlossdrugs #Ozempic #wegovyweightloss #mounjaroweightloss =================================== Subscribe: https://www.youtube.com/@OpentoDebateOrg Official site: https://opentodebate.org/ Newsletter: https://opentodebate.org/insight/ X: https://twitter.com/OpentoDebateOrg Facebook: https://www.facebook.com/BeOpentoDebate/ LinkedIn: https://www.linkedin.com/company/opentodebate/ Instagram: https://www.instagram.com/opentodebateorg/ TikTok: https://www.tiktok.com/@open.to.debate Open to Debate Apple Podcasts: https://tinyurl.com/bdzmz5xt Open to Debate Spotify Podcasts: https://tinyurl.com/22tuxu7h ===================================

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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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This workout is beginner friendly... but that doesn't mean you won't be sweating! Burning fat is not easy, but if you stay consistent the results will come! This weight loss workout is designed for those who are ready and motivated to lose a few inches whilst keeping their joints healthy. 🥑 Diet tips: I always recommend to eat as healthy as possible and drink enough water throughout the day. Avoid soft drinks, have less food that is too high in saturated fats and sodium, eat enough veggies, fruit, protein, but also don't be scared to have rice and pasta as well (everything in moderate portions, your abs won't like too much carbs but the same time your body needs it :)) 🦋 SHARE AND POST YOUR PROGRESS PICTURES ON INSTAGRAM AND USE #getfitbyivana 🌈 BOOTY BOOST PROGRAMS: https://www.getfitbyivana.com/exercise-programs-1 Program designed by me and exercise physiologist to achieve the best results! 🌈 SUBSCRIBE to my BOYFRIEND'S Exercise Channel: @getfitbyjayden 📷 Instagram: getfitbyivana_ https://www.instagram.com/getfitbyivana_/?hl=en 🐦 Twitter: getfitbyivana https://twitter.com/getfitbyivana 📩 Business Enquires: [email protected] Music by: 1) Song: Sad Puppy - Where Did You Go Link: https://youtu.be/Jt2tpmeNIvA Music promoted by FreeMusicWave. 2) Track: Marin Hoxha x Invent - Lost On The Way (ft. Caravn) Music Provided by Magic Records Listen To The Original: https://youtu.be/ykIwoy3Xsw0 Free Download: https://fanlink.to/cyJY 3) Track: Deekrai - Feel You Link: https://youtu.be/85vCVGV4tFU 4) Song: Leonell Cassio - Lie 2 You (ft. Dylan Emmet) Link: https://youtu.be/Gycww3coH5s Music promoted by FreeMusicWave.

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Pretty much everyone in the United States has heard of Paula Deen. The queen of Southern comfort food, Paula Deen’s recipes for cobblers, cheesy casseroles, and stacked sandwiches can make you hungry just thinking about them. However, Paula Deen has come a long way from her rich and hearty meals to delving into something more toned down. After being diagnosed with Type 2 Diabetes, Paula Deen changed things up to lead a much healthier and happier life. Apart from cooking delicious food, there’s a lot more to her life than you know. Check it out, as Paula Deen’s transformation is seriously turning heads. #PaulaDeen #Transformation #Chef Southern roots | 0:00 Cooking as therapy | 1:15 Catering biz | 2:12 Restaurant roots | 2:54 Cookbook star | 3:50 Food Network debut | 4:43 Finding love again | 6:02 Penning her memoir | 7:30 Hiding her health issues | 8:12 The infamous scandal | 9:15 Launching her own network | 10:28 Can't stop, won't stop | 11:22 Read Full Article: https://www.mashed.com/313102/paula-deens-transformation-is-seriously-turning-heads/