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Dr Sundeep Ruder is an endocrinologist in private practice. In this interview with Mia Malan on Bhekisisa’s Health Beat, Ruder explains how Semaglutide works for weight loss. In South Africa, it’s only registered for the treatment of type 2 diabetes, in the form of a weekly injection sold under the brand name Ozempic and made by the drug company Novo Nordisk. Doctors prescribe it “off-label” for weight loss (it’s a relatively commonly accepted practice among doctors worldwide to prescribe medicines “off-label”).

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GLP-1 (Glucagon-Like Peptide-1) inhibitors, more accurately known as GLP-1 receptor agonists, are a class of medications primarily used to treat type 2 diabetes and obesity. Here's a comprehensive look at what they are, how they work, their benefits, and considerations: How They Work: Mimicking GLP-1: GLP-1 receptor agonists mimic the function of the GLP-1 hormone, which is naturally released in the gut in response to food intake. They stimulate insulin secretion from the pancreas when blood glucose levels are high, suppress glucagon release (which would normally increase blood glucose), slow gastric emptying, and increase satiety signals to the brain. Mechanisms: Insulin Release: They help the body release insulin more effectively in response to meals. Glucagon Inhibition: They reduce the amount of glucagon, which helps lower blood sugar. Gastric Emptying: By slowing how quickly food leaves the stomach, they control post-meal blood sugar spikes. Appetite Suppression: They signal to the brain to reduce food intake, aiding in weight management. Benefits: Blood Sugar Control: Effective in lowering HbA1c levels, managing blood sugar in type 2 diabetes. Weight Loss: They have been shown to reduce appetite and body weight, making them useful for obesity management. Cardiovascular and Renal Benefits: Some GLP-1 receptor agonists have demonstrated benefits in reducing cardiovascular risks and improving renal outcomes in diabetic patients. Common Medications: Semaglutide (Ozempic for diabetes, Wegovy for weight loss) Liraglutide (Victoza for diabetes, Saxenda for weight loss) Dulaglutide (Trulicity) Exenatide (Byetta, Bydureon) Tirzepatide (Mounjaro, Zepbound) - a dual agonist that also targets GIP receptor. Side Effects: Gastrointestinal Issues: Nausea, vomiting, diarrhea, and constipation are common, especially when starting treatment. Ozempic Face: Rapid weight loss can lead to sagging skin on the face. Other Side Effects: Less common but more serious side effects include pancreatitis or potential thyroid tumors. Considerations: Administration: Most are injectable, though there's an oral semaglutide option. Cost: These medications can be expensive, potentially limiting access. Off-label Use: There's growing off-label use for weight loss, which brings up debates on ethics, safety, and long-term effects. Insurance and Coverage: Coverage can be variable, with some insurance plans not covering these drugs for weight loss unless certain criteria are met. Long-term Effects: While effective, the long-term effects are still under study, especially with the newer drugs and higher doses used for weight loss. Current Developments: Research: There's ongoing research into their use for other conditions like non-alcoholic fatty liver disease and polycystic ovary syndrome. Market Impact: The popularity of these drugs has significantly influenced the pharmaceutical market, with companies like Novo Nordisk and Eli Lilly seeing substantial growth due to these medications. In summary, GLP-1 receptor agonists represent a significant advancement in managing type 2 diabetes and obesity, offering multiple health benefits alongside some considerations regarding side effects, costs, and ethical use.

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Christina Aguilera's fans have been speculating about her weight loss with Ozempic, but she has not been recognizable to them. Aguilera's blonde hair and smoky eye makeup are recognizable, but her face often looks different. Some fans have shared praise and backhanded compliments, while others question her ability to look younger in each photo. Aguilera is unlikely to explain her appearance changes. #Christina Aguilera's # Aguilera's blonde #looks different. #about her weight # look younger #hollywoodactor #bollywood #modeal #singer #celebrity #actress

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Hey, Team Live Lean! Today, Jessica and I are bringing you an exclusive full-body circuit workout straight from our Team Live Lean Inner Circle. This routine is designed to help you build muscle and torch fat, so get ready to sweat! ✔ Join Team Live Lean For More Workouts: https://bit.ly/3KaTGQx ✔ Live Lean Body Quiz: https://bit.ly/3jTKKUN ✔ Free 7 Day Meal Plan And Recipes: https://bit.ly/36yXeOI Timestamps: 00:00 Full Body Workout Circuit At The Gym 00:13 Barbell Deadlift 01:00 Neutral Grip Pull Up 01:43 Alternating Barbell Reverse Lunge 02:35 Decline Push Up 02:53 Hand Walkout With Push Up 03:23 Barbell Hang Clean And Press 03:55 Dumbbell Walking Lunge 04:10 Forearm Plank Full Body Workout Circuit At The Gym This full-body circuit is perfect for the gym. Complete exercises A1-A8 in circuit format, doing all the reps of each exercise once, then resting for 1 minute before moving on to the next. After finishing the circuit, rest for 2-3 minutes, then, depending on your fitness level, repeat for 1-2 more rounds. Number Of Rounds: Beginners: 1 round Intermediate: 2 rounds Advanced: 3 rounds Rest: 1 minute between exercises within the circuit 2-3 minutes between rounds Full Body Workout Circuit Exercises: A1. Barbell Deadlift Reps: 10 Rest: 1 minute A2. Neutral Grip Pull Up Reps: 10 Rest: 1 minute A3. Alternating Barbell Reverse Lunge Reps: 10 per leg Rest: 1 minute A4. Decline Push Up Reps: 20 Rest: 1 minute A5. Hand Walkout With Push Up Reps: 15 Rest: 1 minute A6. Barbell Hang Clean And Press Reps: 10 Rest: 1 minute A7. Dumbbell Walking Lunge Reps: 10 per leg Rest: 1 minute A8. Forearm Plank Duration: 60 seconds Rest: 1 minute Notes: Remember to maintain proper form throughout each exercise.Adjust weights and modifications according to your fitness level. That's your first round done! If you're a beginner, you've completed the workout. For intermediates and advanced athletes, rest for 2-3 minutes, then repeat for additional rounds based on your fitness level. Get ready to challenge your body and push your limits with this killer full-body circuit. Let's crush those fitness goals together, Team Live Lean! Full Blog Post Here: https://bit.ly/36sBmUX Subscribe Here! http://bit.ly/SubLiveLeanTV Check Out Our Top Videos! http://bit.ly/LiveLeanTVTopVideos WANT MORE DAILY TIPS ON HOW TO LIVE LEAN?: ✔ INSTAGRAM: http://www.instagram.com/bradgouthro ✔ INSTAGRAM: http://www.instagram.com/JessicaGouthroFitness ✔ INSTAGRAM: http://www.instagram.com/LiveLeanTV ✔ SNAPCHAT: http://www.snapchat.com/add/bradgouthro ✔ FACEBOOK: http://www.facebook.com/LiveLeanTV ✔ TWITTER: http://www.twitter.com/bradgouthro ✔ TWITTER: http://www.twitter.com/LiveLeanTV ✔ TIK-TOK: https://www.tiktok.com/@bradgouthro  ✔ TIK-TOK: https://www.tiktok.com/@liveleantv #FullBody #Workouts #LiveLeanTV About Live Lean TV: Welcome to Live Lean TV. The online fitness and nutrition show, hosted by Brad and Jessica Gouthro, teaching you how to LIVE THE LEAN LIFESTYLE 365 days a year. Watch hundreds of fat blasting & muscle building workouts, easy and delicious recipes, as well as fitness and nutrition tips to get you your dream body (and maintain it 365 days a year). Make sure you click the SUBSCRIBE button for new fitness and nutrition episodes every week! Business Enquiries: [email protected] Full Body Workout Circuit At The Gym (BUILD MUSCLE AND BURN FAT) | LiveLeanTV https://www.youtube.com/watch?v=lkwtLnCl0V4 Live Lean TV http://www.youtube.com/LiveLeanTV

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The ketogenic diet has gained popularity among many people and as a result, they are resorting to keto-friendly snacks and treats. These treats have become popular such as Oprah’s Keto Gummies. The product is known as a tasty way of dealing with sweet cravings while maintaining ketosis. But what’s the big deal about Oprah’s Keto Gummies? This article defines the true nature of these gummies that distinguish them from other low-carb snacks which are available in the market.

Unique Flavors Combination

One thing that makes Oprah’s Keto Gummies unique is their distinctive flavors combination. Unlike other keto snacks that may taste bland or artificial, these gummies come in various delicious flavors that are guaranteed to keep you satisfied. From sour citrus to sweet berry, there is something for everyone here. Each piece of this gummy is made in a manner which allows it to release its flavor without negating any of the principles of your ketogenic lifestyle.

High-Quality Components

Another reason why Oprah’s Keto Gummies stand out from others is because they are made of high-quality ingredients. Premium components sourced from trusted suppliers are used by the manufacturers of these gummy bears. The producers know how vital it is for you to munch on only healthy alternative so as not to feel deprived but satisfied too. By opting for Oprah’s Keto Gummies, you may rest assured that you fuel your system with top-grade elements backing up your ketonic existence.

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Many people prefer going keto because they want to cut down on carbs intake among other things. For example, Oprah’s Keto Gummies are designed with limited carbohydrate content compared to other types of snacks meant for individuals on keto diets.On each count, one gets a satisfying treat without falling off track.The routine introduction of these jellies will therefore not break your strides off ketosis.

A Convenient On-the-Go Option

Sometimes our lives get busy making it hard for us to access keto-friendly snacks. Oprah’s Keto Gummies are convenient options for fast, easy snacks that fit within your diet. These gummies come in portable packaging that you can easily toss into your bag or pocket for a grab-and-go treat.Whether you’re at work, out running errands, or on the move, you can be sure of staying within keto through these gummy bears.

Positive Customer Reviews

Finally, many people have given positive feedback on how they feel about Oprah’s Keto Gummies. Those who have tried them before speak well of their enticing taste plus the packing and ingredients that are safe for ketogenic living. Such reviews show that these gummies helped someone to keep a balanced nutrition while following the dietary plan and as such were sweet than common sugar-contained munchies. The plethora of positive responses underscores the credibility and attraction of this brand’s product.

Summary

Finally, it is important to note that the Oprah’s Keto Gummies are a special and original keto-friendly snack. They also provide a good example of delicious flavors, natural ingredients, few carbs and ease of accessibility with positive feedbacks from clients; these gummies are just as satisfying as they are healthy. If you want a sweet-tooth killing method that will not sidetrack your diet in any way shape or form then it would be well worth having some of these. Try them out and you will know what sets them apart from other keto snacks available today.

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💉 What is GLP-1 and should you be taking it? In this video, we break down everything you need to know about GLP-1 receptor agonists — the trending medications behind weight loss drugs like Ozempic, Wegovy, and Mounjaro. 🎯 We cover: ✅ What GLP-1 actually is and how it works in the body ✅ The pros and cons of using GLP-1 for weight loss ✅ Who it’s designed for — and who should avoid it ✅ What happens when you stop taking GLP-1 ✅ Natural alternatives and lifestyle considerations ✅ How we approach sustainable fat loss at Fitagain, especially for people over 40 and 50 ⚠️ This video is for educational purposes only and is not medical advice. Always consult your GP before starting any medication. 🏋️‍♀️ At Fitagain, we specialise in helping people over 40 and 50+ achieve lasting weight loss, improve strength, and feel confident in their bodies again — without fads or quick fixes. 👉 Learn more or book your free consultation: www.fitagain.co.uk 📲 Follow us on Instagram: @fitagain.uk 📍 Based in the Devon countryside 🔔 Subscribe for weekly advice on weight loss, strength training, and health over 50. #GLP1 #Ozempic #Wegovy #WeightLossOver40 #GLP1Explained #fatlossover40 #MenopauseWeightLoss #fitagain #fitnesseducation #SustainableWeightLoss #seniorfitness #devon #personaltrainer #healthyliving #fatlosstips