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The video version of this podcast can be found here: https://youtu.be/W0LL-1BwV3w?si=OT-GNCXaHoA7dcbs This podcast makes reference to guidelines produced by the "National Institute for Health and Care Excellence" in the UK, also referred to as "NICE". Please note that the content on this channel reflects my professional interpretation/summary of the guidance and that I am in no way affiliated with, employed by or funded/sponsored by NICE. My name is Fernando Florido and I am a General Practitioner in the United Kingdom. In this video I will go through a National Patient Safety Alert released on 3.1.2024 by the Department of Health and NHS England on the shortage of GLP1 receptor agonists, touching on sections of the NICE guideline on type 2 diabetes as well as relevant pharmaceutical information, always focusing on what is relevant in Primary Care only. I am not giving medical advice; this video is intended for health care professionals; it is only my summary and my interpretation of the guidelines and you must use your clinical judgement. There is a podcast version of this and other videos that you can access here: Primary Care guidelines podcast: · Redcircle: https://redcircle.com/shows/primary-care-guidelines · Spotify: https://open.spotify.com/show/5BmqS0Ol16oQ7Kr1WYzupK · Apple podcasts: https://podcasts.apple.com/gb/podcast/primary-care-guidelines/id1608821148 There is a YouTube version of this and other videos that you can access here: • The Practical GP YouTube Channel: https://youtube.com/@practicalgp?si=ecJGF5QCuMLQ6hrk The PDF document related to the safety alert on GLP- RA shortage can be found here: · https://www.cas.mhra.gov.uk/ViewandAcknowledgment/ViewAttachment.aspx?Attachment_id=104161 The safety alert on GLP- RA shortage can be found here: · https://www.cas.mhra.gov.uk/ViewandAcknowledgment/ViewAlert.aspx?AlertID=103245 The Central Alerting System Homepage can be found here: · https://www.cas.mhra.gov.uk/Home.aspx Intro / outro music: Track: Halfway Through — Broke In Summer [Audio Library Release] • Music provided by Audio Library Plus • Watch: https://youtu.be/aBGk6aJM3IU (https://www.youtube.com/watch?t=0s&v=aBGk6aJM3IU) • Free Download / Stream: https://alplus.io/halfway-through (https://www.youtube.com/redirect?event=video_description&q=https%3A%2F%2Falplus.io%2Fhalfway-through&redir_token=QUFFLUhqbVNpZlBNM0lCeDIxQzRkU29qUnJGQy15WEtTQXxBQ3Jtc0tuUUFSMkZwSEVuaHdUTWlYV21fZmpjWS1WRXI3R0hZU056MkpmRFpKdXdGYm1La3BlazhUemZ5SkVMTFdaWWRvSG9Ucy1neWpudTJ0MUIxNnl2NmhvR0lmdzduWXEwUUg0alduYkRNdjlWWTNsMnhzaw&v=aBGk6aJM3IU) Transcript If you are listening to this podcast on YouTube, for a better experience, switch to the video version. The link is in the top right corner of the video and in the episode description. Hello and welcome, I am Fernando, a GP in the UK. In this episode I will go through a National Patient Safety Alert released on 3.1.2023 by the Department of Health and NHS England on the shortage of GLP1 receptor agonists, touching on sections of the NICE guideline on type 2 diabetes as well as relevant pharmaceutical information, always focusing on what is relevant in Primary Care only. If you want to access the safety alert website or the associated PDF document, the link is in the episode description. Right, let’s jump into it. You are probably aware that the supply of GLP-1 receptor agonists continues to be limited, with supplies not expected to return to normal until at least the end of 2024. The supply issues have been caused by an increase in demand for these products for licensed and off-label indications. The situation at the moment is that exenatide as Byetta® will be discontinued in March 2024. In addition, liraglutide as Victoza® continues to be out of stock and further stock is not expected until end of 2024. The supply of other agents such as injectable semaglutide as Ozempic® and Dulaglutide as Trulicity® may be unreliable and the shortages may cause significant issues. So, what is the solution? Well, oral semaglutide has come to the rescue. Semaglutide as Rybelsus® tablets are now available in sufficient quantities to support initiation of GLP-1 RA for type 2 diabetes in line with NICE guidance. So let’s remind ourselves of what NICE recommends for type 2 diabetes. NICE says that if triple therapy with metformin and 2 other oral drugs is not effective, not tolerated or contraindicated, we can consider triple therapy by switching one drug for a GLP‑1 receptor agonist if: · The BMI is 35 or higher and there are psychological or medical problems associated with obesity. We will adjust the BMI to 32.5 for people from Black, Asian and other minority ethnic groups or · For lower BMIs if: o insulin would have occupational implications or o weight loss would benefit other significant comorbidities. NICE also says that we should only ...
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Health Canada is reviewing the class of drugs used in diabetes and weight-loss medications like Ozempic, following reports that they may lead to a risk of suicide. Other health agencies in the U.K. and Europe are also conducting similar reviews. #weightloss #health #cbcnews Watch The National live on YouTube Sunday-Friday at 9 p.m. ET Subscribe to The National: https://www.youtube.com/user/CBCTheNational?sub_confirmation=1 Connect with The National online: Facebook | https://www.facebook.com/thenational Twitter | https://twitter.com/CBCTheNational Instagram | https://www.instagram.com/cbcthenational More from CBC News | https://www.cbc.ca/news The National is the flagship of CBC News, showcasing award-winning journalism from across Canada and around the world. Led by Chief Correspondent Adrienne Arsenault and Ian Hanomansing, our team of trusted reporters help you make sense of the world, wherever you are. The National was named Canada’s Best National Newscast by the Canadian Screen Awards and RTDNA Canada.
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She's Mad Because People Are Losing Weight! I appreciate everyone who watches, please check out my Instagram - Twitter - Discord, And my Second Channel Discord - https://discord.gg/gy4cbgRgHz Insta - https://www.instagram.com/Not_DayVit/ X - https://twitter.com/Not_DayVit?t=F4dWcnSGMEnzhGXqY9Wotw&s=09 *Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. No copyright infringement intended. ALL RIGHTS BELONG TO THEIR RESPECTIVE OWNERS *Disclaimers: all opinions are my own, sponsors are acknowledged. Not financial advice, for entertainment purposes only.
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REFERENCE for Curious Interested Listeners & Physicians 48,25mar In Part 2 of our deep dive into Mounjaro vs. Ozempic, we’re busting myths and uncovering what doctors aren’t always saying. Here’s what we’ll cover: • Myth 1: “All GLP-1 drugs are the same.” • Reality: Ozempic targets a single pathway, while Mounjaro works on two—leading to potential greater weight loss in some, but it’s not a one-size-fits-all. • Myth 2: “These drugs only make you eat less.” • Reality: They also influence the brain’s reward system, reducing cravings and the emotional drivers of eating, not just physical hunger. We’ll break down how these medications work, the real-world impact, and why individual responses vary. Stay tuned Part 3 for more insights into what doctors might not be telling you about these weight loss treatments! 1. Animal Studies Alhadeff AL, Rupprecht LE, Hayes MR. (2012). Glucagon-like peptide-1 receptor signaling in the ventral tegmental area attenuates food intake. Journal of Neuroscience, 32(25), 8112-8120. Showed GLP-1 drugs reduce food-seeking behavior by acting on brain reward areas. 2. Brain Reward Pathways Dickson SL, Shirazi RH, Hansson C, et al. (2012). The role of GLP‑1 receptor activation in the central regulation of energy balance and reward. Physiology & Behavior, 106(2), 231–238. Explains how GLP-1 receptors in the brain influence eating for pleasure, not just hunger. 3. Incretin Hormones Review Nauck MA & Meier JJ. (2018). Incretin hormones: Their role in health and disease. Diabetes, Obesity and Metabolism. Details the dual role of GLP-1 in gut and brain signaling. 4. The SURPASS-2 Trial Jastreboff, A. M., et al. (2022). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2): A Randomized, Open-Label, Parallel-Group, Phase 3 Trial. This study and provided weight loss data for both tirzepatide (Mounjaro) and semaglutide (Ozempic). 5. The SURPASS Clinical Trials (Review and Meta-Analysis) Frías, J. P., et al. (2022). Insights from the SURPASS Clinical Trials: A Systematic Review and Meta-Analysis of Tirzepatide in Type 2 Diabetes. Diabetes, Obesity and Metabolism. Discusses how the additional GIP receptor activity might contribute to enhanced weight loss. 6. Eli Lilly (Mounjaro) https://www.lilly.com/news/media/media-kits/mounjaro https://mounjaro.lilly.com 7. Novo Nordisk (Ozempic) https://www.novonordisk.com.au/our-products-for-healthcare-professionals.html https://rss.medsinfo.com.au/no/pi.cfm?product=nopozemp
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