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Drs Akshay Jain and Lorenzo Leggio discuss GLP-1 RA therapy and its potential to mitigate alcohol misuse syndrome. https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt --TRANSCRIPT-- Akshay B. Jain, MD: Today we are very excited to have Dr Leggio join us all the way from the National Institutes of Health (NIH). He is an addiction physician scientist in the intramural research program at NIH. Welcome, Dr Leggio. Thanks for joining us. Lorenzo Leggio, MD, PhD: Thank you so much. Jain: We'll get right into this. Your session was, in my mind, extremely informative. The session looked at glucagon-like peptide 1 receptor agonist (GLP-1 RA) therapy and its potential effects on mitigating alcohol misuse syndrome, so, reduction of alcohol addiction potentially. We've seen in some previous clinical trials, including many from your group, that alcohol use is known to be reduced — the overall risk of incidence, as well as recurrence of alcohol use — in individuals who are on GLP-1 RA therapy. Can you share more insights about the data already out there? Leggio: At the preclinical level, we have a very robust line of studies, experiments, and publications looking at the effect of GLP-1 RAs, starting from exenatide up to, more recently, semaglutide. They show that these GLP-1 RAs do reduce alcohol drinking. They used different animal models of excessive alcohol drinking, using different species — for example, mice, rats, nonhuman primates — models that reflect the excessive alcohol drinking behavior that we see in patients, like physical alcohol dependence or binge-like alcohol drinking, and other behaviors in animal models that reflect the human condition. In addition to that, we recently have seen an increase in human evidence that GLP-1 RAs may reduce alcohol drinking. For example, there is some anecdotal evidence and some analyses using social media showing that people on GLP-1 RAs report drinking less alcohol. There are also some pharmacoepidemiology studies which are very intriguing and quite promising. In this case, people have been looking at electronic medical records; they have used the pharmacoepidemiology approaches to match patients on GLP-1 RAs because of diabetes or obesity, and have compared and matched to patients on different drugs as the controls. A study was recently published in Nature Communications by a group in Cleveland in collaboration with Dr Nora Volkow from the National Institute on Drug Abuse. This study shows the association between being on a GLP-1 RA and the lower incidence of alcohol use disorder and lower drinking. There is also some promise from prospective randomized clinical trials. In particular, there was one clinical trial from Denmark, a well-known and -conducted clinical trial where they looked at exenatide, and they didn't see an effect of exenatide compared with placebo in the main analysis. But in a subanalysis, they did see that exenatide reduced alcohol drinking, but only in patients with alcohol use disorder and obesity. This suggests that these medications may work for some patients and not for other patients. That's fine, because just like in any other field in medicine, including diabetes, obesity, hypertension, Parkinson's, and depression, not all medications work for everybody. If these medications will work for alcohol addiction, we do not expect that they will work for everybody. One ongoing question in the field is to try to identify the phenotypes or the subgroup of people who may be more responsive to these medications. Jain: This is such a fascinating field, and all these studies are coming out. In your review of all the literature so far, do you think this is dose dependent? Also, we see that, for instance, with certain individuals, when they take GLP-1 RA therapy, they might have a lot of gastrointestinal (GI) side effects. Recent studies have shown that the rate of these GI side effects does not necessarily correlate with the amount of weight loss. In the alcohol addiction field, do you think that the GI side effects, things like nausea, could also have a potential role in mitigating the alcohol addiction? Leggio: This is a great question. They may play a role; they may contribute, too, but we don't think that they are the driving mechanism of why people drink less, for at least a couple of reasons. One is that, similar to the obesity field, the data we have so far don't necessarily show a relationship between the GI side effects and the reduction in drinking. Plus, the reduction in drinking is likely to happen later when many GI side effects are gone or attenuated. Transcript in its entirety can be found by clicking here: https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt
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In recent years, the keto diet has gained popularity for its ability to help people lose weight and improve their overall health. One of the latest products to hit the market is keto tablets that claim to boost ketosis and accelerate fat burning. But are these keto tablets really worth it? In this article, we will delve into the world of Shark Tank’s keto tablets to determine if they live up to the hype.
The Science Behind Keto Tablets
Keto tablets are designed to help people following a ketogenic diet reach ketosis more quickly. Ketosis is a metabolic state where the body burns fat for fuel instead of carbohydrates, leading to weight loss. These tablets typically contain exogenous ketones, such as beta-hydroxybutyrate (BHB), which can help increase blood ketone levels and support ketosis. However, it is important to note that taking keto tablets alone will not guarantee weight loss. They should be used in conjunction with a healthy diet and regular exercise for optimal results.
Potential Benefits of Keto Tablets
Proponents of keto tablets claim that they can provide a variety of benefits beyond weight loss. Some people report increased energy levels, improved mental clarity, and better athletic performance when taking these supplements. Additionally, keto tablets may help curb cravings and reduce hunger, making it easier to stick to a ketogenic diet. However, individual results may vary, and more research is needed to fully understand the long-term effects of keto tablets on overall health.
Potential Risks of Keto Tablets
While keto tablets may offer some benefits, there are also potential risks to consider. Some people may experience digestive issues, such as bloating, diarrhea, and stomach cramps, when taking these supplements. In addition, there is limited regulation of the supplement industry, so it is important to choose keto tablets from reputable brands that undergo third-party testing. It is always recommended to consult with a healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions.
Real People, Real Results?
Many supplement companies use testimonials and before-and-after photos to showcase the effectiveness of their products. However, it is important to approach these claims with caution. While some people may see positive results from taking keto tablets, others may not experience the same outcomes. Factors such as genetics, diet, exercise, and overall health can all play a role in how well keto tablets work for an individual. It is always best to set realistic expectations and focus on making sustainable lifestyle changes for long-term success.
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In conclusion, Shark Tank’s keto tablets may offer some benefits for people looking to enhance their ketogenic diet. However, they are not a magic solution for weight loss and should be used as part of a comprehensive approach to health and wellness. Before trying keto tablets, it is important to do your research, consult with a healthcare provider, and prioritize a balanced diet and regular exercise. Ultimately, the decision to try keto tablets is a personal one that should be based on individual goals, preferences, and health considerations.
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The ketogenic diet has become increasingly popular in Australia and around the world for its numerous health benefits, including weight loss, improved blood sugar control, and enhanced mental clarity. However, sticking to a strict keto diet can be challenging, especially when it comes to satisfying your sweet tooth. Fortunately, Apple Keto Gummies in Perth offer a delicious and convenient solution for those following a ketogenic lifestyle.
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Australia has experienced a surge in popularity when it comes to the ketogenic diet, with more and more people looking to improve their health and well-being through low-carb, high-fat eating. The keto diet involves drastically reducing your carbohydrate intake and replacing it with healthy fats, which puts your body into a state of ketosis where it burns fat for fuel instead of carbs.
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However, while the ketogenic diet has been shown to offer a wide range of benefits, including weight loss, increased energy levels, and reduced inflammation, many people struggle to find keto-friendly snacks that satisfy their cravings. That’s where Apple Keto Gummies come in, offering a delicious and guilt-free treat that fits perfectly into a keto lifestyle.
The Perfect Keto Treat
Apple Keto Gummies are made with only the highest quality ingredients, including grass-fed gelatin, organic apple extract, and natural sweeteners like stevia and erythritol. Each gummy is perfectly portioned to provide a burst of fruity flavor without any added sugars or artificial additives, making them a great option for anyone looking to indulge in a sweet treat without derailing their keto progress.
Not only are Apple Keto Gummies delicious, but they’re also incredibly convenient for busy individuals on the go. Whether you’re looking for a quick snack to satisfy your afternoon cravings or a tasty treat to enjoy after dinner, these gummies are the perfect solution. Plus, they’re easy to carry with you wherever you go, so you’ll always have a keto-friendly option on hand.
Unlocking the Benefits of Apple Keto Gummies
In addition to being a tasty and convenient snack, Apple Keto Gummies offer a variety of health benefits thanks to their carefully selected ingredients. The grass-fed gelatin used in these gummies is rich in collagen, which can help improve the health of your skin, hair, and nails. Meanwhile, the organic apple extract provides a natural source of antioxidants and vitamins, supporting your overall well-being.
Whether you’re new to the ketogenic diet or a seasoned pro, Apple Keto Gummies are the perfect way to satisfy your cravings while staying on track with your health goals. With their delicious flavor, high-quality ingredients, and convenient packaging, these gummies are sure to become a staple in your keto pantry. Say goodbye to sacrificing taste for nutrition and hello to a tasty keto delight with Apple Keto Gummies in Perth.
FAQ
Q: Are Apple Keto Gummies suitable for vegans?
A: Unfortunately, Apple Keto Gummies are not vegan-friendly, as they contain grass-fed gelatin sourced from animal products.
Q: How many gummies come in a pack?
A: Each pack of Apple Keto Gummies contains approximately 30 gummies, providing plenty of servings for your snacking needs.
Q: Can I eat Apple Keto Gummies if I’m not following a ketogenic diet?
A: While Apple Keto Gummies are specifically designed for those following a ketogenic lifestyle, anyone can enjoy these delicious gummies as a healthier alternative to traditional sweets.
Q: Do Apple Keto Gummies contain any artificial ingredients?
A: No, Apple Keto Gummies are made with natural, high-quality ingredients and are free from artificial sweeteners, colors, and preservatives.
Q: Where can I purchase Apple Keto Gummies in Perth?
A: Apple Keto Gummies are available for purchase online or at select health food stores in Perth, making it easy to get your hands on these tasty treats.
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Are you eating healthy, exercising regularly, and still not losing weight — especially after 50? You’re not alone. In this video, I break down exactly why your fat loss has stalled despite doing “everything right.” Whether you're following a clean eating plan, working out consistently, or even counting calories and still not seeing results, this is the video that explains the real reasons behind stubborn weight gain, especially during perimenopause and menopause. From metabolic slowdown and insulin resistance to protein intake, stress, hormones, and fat adaptation — we’ll connect the dots between midlife metabolism and sustainable fat loss strategies that actually work. If you're over 40, 50 or 60 and feel frustrated with traditional diet advice that just doesn't work anymore, this is the truth you’ve been waiting for. Learn how to boost your metabolism naturally, burn stubborn belly fat, fix your hunger hormones, and finally get the results your hard work deserves — without extreme restriction, obsessive calorie counting, or feeling hungry all the time. Subscribe for more real talk on fat loss, intermittent fasting, metabolic health, and simple, sustainable strategies to get strong, lean and energised for life. Eating Healthy and Exercising but NOT Losing Weight. Eating Well and Exercising but NOT Losing Weight? Here’s What WORKS! || Emma Voysey If you found this video helpful, please LIKE, SUBSCRIBE, and SHARE with friends who deserve to know these secrets too! 💬 Drop a comment if this hit home — I’d love to hear your story. Want more health insights, exclusive tips, and personal updates straight to your inbox? Join my EmmaVoyseyHealth email community! You'll be the first to receive practical health strategies, inspiring stories, and special content I don't share anywhere else: 👉 https://emmavoyseyhealth.kit.com/9a72ee5b4c 😍 𝐈 𝐇𝐎𝐏𝐄 𝐘𝐎𝐔 𝐆𝐔𝐘𝐒 𝐄𝐍𝐉𝐎𝐘 𝐓𝐇𝐈𝐒! ▶️ If you enjoy this video, please like it and share it. ▶️ Don't forget to subscribe to this channel for more updates. 👉𝑷𝒍𝒆𝒂𝒔𝒆 𝒔𝒉𝒂𝒓𝒆 𝒘𝒊𝒕𝒉 𝒚𝒐𝒖𝒓 𝒇𝒓𝒊𝒆𝒏𝒅𝒔 𝒂𝒏𝒅 𝒇𝒂𝒎𝒊𝒍𝒚. 𝑨𝒍𝒔𝒐 𝒅𝒐𝒏'𝒕 𝒇𝒐𝒓𝒈𝒆𝒕 𝒕𝒐 𝒍𝒊𝒌𝒆, 𝒔𝒖𝒃𝒔𝒄𝒓𝒊𝒃𝒆, 𝒂𝒏𝒅 𝒉𝒊𝒕 𝒕𝒉𝒆 𝒏𝒐𝒕𝒊𝒇𝒊𝒄𝒂𝒕𝒊𝒐𝒏 𝒃𝒆𝒍𝒍 𝒕𝒐 𝒏𝒐𝒕𝒊𝒇𝒚 𝒚𝒐𝒖 𝒊𝒇 𝑰 𝒑𝒐𝒔𝒕 𝒂 𝒏𝒆𝒘 𝒗𝒊𝒅𝒆𝒐. ============================================================== CONNECT WITH ME: 👉FACEBOOK:- / emmavoyseyhealth 👉INSTAGRAM: / emmavoyseyhealth 👉WEBSITE: http://www.EMMAVOYSEYHEALTH.com ============================================================== ▶️ 𝐇𝐀𝐒𝐇𝐓𝐀𝐆𝐒: #eatwelllivewell #healthyhabits #mindfuleating #exerciseforhealth #holistichealth #weightloss #healthylifestyle #wellnessjourney #healthymindandbody #everydaywellness #emmavoysey #bodypositivefitness #eattofeelgood #kto#ketogenic#ketogenic diet#ketodiet#lowcarbdiet Typical legal disclaimer (occupational hazard!): This is not medical advice, nor can I give you medical advice. Sorry! Everything here is for informational purposes only and not for the purpose of providing medical advice. You should contact your doctor to obtain advice with respect to any particular health issue or condition. Nothing here should be construed to form a doctor patient relationship. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. EmmaVoyseyHealth is not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site. Also, some of the links in this post may be affiliate links, meaning, at no cost to you, I may earn a small commission if you click through and make a purchase. But if you click, it really helps me make more of these videos!
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