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Watch the full episode and view show notes here: http://bit.ly/3Tap47T Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ In this “Ask Me Anything” (AMA) episode, Peter focuses the discussion on two topics getting a lot of attention recently. He first dives deep into GLP-1 agonists, most notably semaglutide and tirzepatide, which originally came to market as diabetes drugs but are now being studied and prescribed for weight loss. He walks through the data and compares the effectiveness of the two drugs, the side effects, and perhaps more importantly, his reservations around wide use of these drugs and who he would consider to be a candidate for them. Next, Peter discusses how metformin, another drug originally brought to market for diabetes management, gained popularity as a potential longevity drug even for non-diabetics. Peter gives his take on this possibility and reviews data from a more recent study investigating the question of whether metformin should be used for general “geroprotection.” In this sneak peek, we discuss: 00:00 - Intro 00:08 - The hype around semaglutide, tirzepatide, and other GLP-1 agonists for weight loss 04:09 - Overview of GLP-1 agonists and why these drugs are getting so much attention 12:20 - Defining the term “geroprotective” 14:08 - Semaglutide: background, brand names, indications, and more 19:10 - Tirzepatide: background, brand names, indications, and more In the full episode, we also discuss: -How semaglutide and tirzepatide compare in their efficacy in terms of weight loss and other metabolic health metrics; -Data showing sustained weight loss and improved metabolic metrics with after more than a year of using semaglutide and tirzepatide; -What happens to body weight when a patient discontinues the medication?; -Noteworthy side effects of GLP-1 agonists and similar classes of drugs; -Increased resting heart rate and other concerning trends in patients using GLP-1 agonists; -Changes in body composition (body fat and lean muscle) in patients on GLP-1 agonists; -Possible reasons for the loss of lean muscle mass and tips for protecting lean mass; -GLP-1 agonists and thyroid cancer; -Who might be a candidate for GLP-1 agonists?; -The large financial cost of this class of drugs; -Metformin as a geroprotective drug: origin of the idea that metformin could be a longevity agent even for non-diabetic patients; -A 2022 study on metformin sheds more light on the question of whether metformin should be used for “geroprotection” in non-diabetics; -Peter’s current approach with metformin for his patients; and -More. -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.

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Schnell abnehmen ist das Ziel vieler Menschen, die unzufrieden mit ihrem Körper sind oder aus gesundheitlichen Gründen Gewicht verlieren müssen. Es gibt viele bewährte Methoden, um schnell abzunehmen, aber auch immer wieder neue Erkenntnisse und Techniken, die helfen können, das Gewicht dauerhaft zu reduzieren. In diesem Artikel werden wir auf einige dieser Methoden eingehen und Ihnen zeigen, wie Sie Ihr Ziel erreichen können.

Bewährte Methoden

Eine der effektivsten Methoden, um schnell abzunehmen, ist eine Kombination aus gesunder Ernährung und regelmäßiger Bewegung. Durch eine ausgewogene Ernährung, die reich an Gemüse, Obst, magerem Eiweiß und guten Fetten ist, können Sie Ihr Gewicht langfristig reduzieren. Bewegung in Form von Cardio- und Krafttraining hilft dabei, Kalorien zu verbrennen und Ihre Muskeln zu stärken, was wiederum Ihren Stoffwechsel ankurbelt.

Eine weitere bewährte Methode zum schnellen Abnehmen ist das Intervallfasten. Hierbei wechseln sich Phasen des Nahrungsverzichts mit Essenszeiten ab, was dazu führt, dass der Körper effizienter Fett verbrennt und somit Gewicht verliert. Intervallfasten kann auch dazu beitragen, den Blutzuckerspiegel zu stabilisieren und das Risiko für Krankheiten wie Diabetes zu reduzieren.

Neben Ernährung und Bewegung spielt auch ausreichender Schlaf eine wichtige Rolle beim Abnehmen. Studien haben gezeigt, dass Schlafmangel zu einem Anstieg des Hormons Ghrelin führen kann, das den Hunger erhöht. Ausreichender Schlaf hingegen reguliert den Hormonhaushalt und hilft dabei, das Gewicht zu kontrollieren.

Neue Erkenntnisse

In den letzten Jahren haben Wissenschaftler viele neue Erkenntnisse darüber gewonnen, wie der Körper funktioniert und wie man am effektivsten Gewicht verlieren kann. Eine dieser neuen Erkenntnisse ist die Bedeutung des Darmmikrobioms für die Gewichtsabnahme. Eine gesunde Darmflora kann dazu beitragen, dass der Körper Nährstoffe besser aufnimmt und Fett effizienter verbrennt.

Eine weitere neue Erkenntnis ist die Rolle von Stress beim Abnehmen. Studien haben gezeigt, dass chronischer Stress zu einer erhöhten Produktion von Cortisol führen kann, einem Hormon, das den Stoffwechsel verlangsamt und die Fettverbrennung hemmt. Daher ist es wichtig, Stress abzubauen, um erfolgreich Gewicht zu verlieren.

Auch die Bedeutung von spezifischen Nahrungsmitteln für die Gewichtsabnahme wurde in den letzten Jahren intensiv erforscht. Superfoods wie Chia-Samen, Avocado oder Quinoa können dabei helfen, den Stoffwechsel anzukurbeln und die Fettverbrennung zu fördern.

Zusammenfassung

Insgesamt gibt es viele bewährte Methoden und auch neue Erkenntnisse, die dabei helfen können, schnell abzunehmen. Eine Kombination aus gesunder Ernährung, regelmäßiger Bewegung, ausreichend Schlaf und Stressabbau ist der Schlüssel zum Erfolg. Probieren Sie verschiedene Methoden aus und finden Sie heraus, was am besten für Sie funktioniert. Konsultieren Sie im Zweifelsfall einen Experten, um individuelle Tipps und Ratschläge zu erhalten.

Das wichtigste ist jedoch, geduldig zu sein und sich nicht zu sehr unter Druck zu setzen. Schnelles Abnehmen kann zwar motivierend sein, aber langfristiger Erfolg erfordert Zeit und Engagement. Mit der richtigen Herangehensweise und der nötigen Disziplin können Sie Ihr Ziel erreichen und dauerhaft gesund abnehmen.

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