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Pfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #

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Scroll to the bottom for the recipe Disclaimer: The information on our channel is not meant as medical advice. It is simply our experience. Please talk with your healthcare team about your specific health needs. ************************************************** Welcome to Keto Living With Dale & Judith where we share our experiences living an active keto lifestyle with the goal of aging well. Why Keto? Keto helps me maintain my 150lbs weight loss and manage Rheumatoid Arthritis while Dale maintains his 60lbs weight loss and manages his Type 2 Diabetes. Here we share tips, products, recipes and our keto journey. Instagram: https://instagram.com/ketolivingwithdaleandjudith?igshid=OGQ5ZDc2ODk2ZA%3D%3D&utm_source=qr Facebook: https://www.facebook.com/profile.php?id=61552255676360&mibextid=LQQJ4d This is the app we use to plan and track our food. We find the upgrade subscription worth the annual fee. Carb Manager https://apps.apple.com/us/app/carb-manager-keto-diet-tracker/id410089731 Ketone Meter Amazon affiliate links: KetoTrak Meter https://amzn.to/3NrwEcs #ad KetoTrak Test Strips https://amzn.to/3RGRGGm #ad ************** Black & White Cookie Bars Recipe Makes 16 Bars 1 Bar = 1.5g NC 1c Almond Flour 1/2c Confectioners Swerve or Xylitol 1 tsp Baking Powder 1 Tbs Unflavored Gelatin 1/2 tsp Salt 1 Stick Salted Butter 4 Egg Yolks 1 tsp Vanilla Extract 1/4c Choc Zero Dark Baking Chips 1/4c Choc Zero White Baking Chips https://www.choczero.com/collections/keto-baking-ingredients Preheat oven to 325° Mixed together almond flour, Keto sweetener, gelatin, salt and baking powder. Mix in the melted butter. Stir vanilla extract into egg yolks. Add egg yolks & mix well. Mix in baking chips. Oil 8 x 8 pan. Press batter into pan. Batter will be very thick. Bake on center rack of oven 30-35 minutes or until edges & top are browned. Remove from oven and cool on a wire rack. Hot bars will be very gooey. Bars firm up as they cool. Chill before cutting. Note: Choc Zero does not sponsor this video or our channel. They are simply a brand that we personally use and enjoy.

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Over the years, weight loss has been a major concern for many individuals looking to improve their health and overall well-being. One of the latest advancements in weight loss medication is Semaglutide, a prescription medicine that has shown promising results in helping individuals achieve their weight loss goals. As more and more people are turning to Semaglutide for weight loss, it is important to look at comprehensive reviews from actual users to understand its effectiveness and potential side effects.

User Experience with Semaglutide

Many users who have tried Semaglutide for weight loss have reported positive experiences with the medication. They have mentioned that Semaglutide helped them suppress their appetite, leading to fewer cravings and ultimately, weight loss. Users also noted an increase in energy levels, which motivated them to engage in physical activities and exercise regularly.

Additionally, users have commented on the convenience of Semaglutide as a once-weekly injection, making it easier to adhere to the medication regimen. Some users have also mentioned improvements in their blood sugar levels and overall health markers, indicating that Semaglutide not only aids in weight loss but also has potential benefits for managing other health conditions.

Potential Side Effects

While many users have had positive experiences with Semaglutide, some have reported experiencing side effects while taking the medication. Common side effects include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to resolve on their own over time as the body adjusts to the medication.

It is important to note that Semaglutide may not be suitable for everyone, especially individuals with a history of pancreatitis or thyroid tumors. It is essential to consult with a healthcare provider before starting Semaglutide to determine if the medication is safe and appropriate for your specific health conditions.

Long-Term Effects and Sustainability

Many users have raised concerns about the long-term effects of Semaglutide on weight loss and overall health. While Semaglutide has shown promising results in short-term studies, the sustainability of weight loss with the medication over an extended period is still being researched.

Some users have also questioned the long-term safety of Semaglutide and its potential impact on metabolic health. It is crucial for individuals using Semaglutide for weight loss to monitor their progress closely and communicate any concerns or changes in their health to their healthcare provider.





Final Thoughts on Semaglutide Weight Loss

Overall, comprehensive reviews from users suggest that Semaglutide can be an effective tool for weight loss when used in conjunction with a healthy diet and regular exercise. While the medication may have some side effects, many users have found the benefits of Semaglutide outweigh these potential risks.

As with any weight loss medication, it is important to approach Semaglutide with caution and under the guidance of a healthcare professional. By staying informed and proactive about your health, you can make educated decisions about incorporating Semaglutide into your weight loss journey.

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Ozempic and Mounjaro are two injectable treatments that are currently creating a buzz. Whether it’s celebrities, social media influencers, or businessmen, everyone is losing weight and achieving their desired body shape through these injections. While these treatments are gaining popularity on one hand, on the other hand, they are also raising several questions in people’s minds. To answer these questions and clear up any confusion, this video features Dr. Vineeta Pathak, a reputed dermatologist and skincare specialist at Dr. Haror’s Wellness, who addresses some common queries to help you make an informed decision. So if you're also considering trying Ozempic or Mounjaro, then this video is for you. ======================= 📍 Visit Dr. Haror's Wellness Clinic at any of our Pan India branches: 📌 Location: - Delhi: Greater Kailash 1 | Preet Vihar | Rajouri Garden | Model Town - Gurgaon, Haryana - Bengaluru, Karnataka - Kolkata, West Bengal - Indore, Madhya Pradesh - Ranchi, Jharkhand ======================= 🌐 Book a consultation: https://drharorswellness.com/book-appointment/ 📞 Call us: +91 963 78 666 66 ======================= Follow Dr. Haror's Wellness for more expert insights on weight loss, dermatology, and hair restoration: 📘 Facebook: https://www.facebook.com/dr.harorswellness/ 📸 Instagram: https://www.instagram.com/dr.harorswellness/ ======================= 🔔 Subscribe for more medical updates & aesthetic solutions https://www.youtube.com/@drharorswellness/ 👍 Like | 💬 Comment | 📤 Share ======================= #WeightLossIndia #WeightLossInjection #OzempicIndia #MounjaroIndia #MedicalWeightLoss #ObesityTreatmentIndia #WeightManagementClinic #GLP1Treatment #DoctorLedWeightLoss #DrVineetaPathak #DrHarorsWellness #HealthyLivingIndia #PharmaInnovation #WellnessClinicIndia #WeightLossJourneyKeto Ultra Diet Reviews Shark Tank Public Review

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