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#diabetes #weightloss #diabetesdrug Research Reveals Method to Improve Diabetes and Weight-Loss Drug Performance According to new research from the University of Michigan, a network of proteins found in the central nervous system could be leveraged to enhance the effectiveness and minimize the side effects of popular diabetes and weight-loss medications. The study, published in the Journal of Clinical Investigation, focused on two proteins, melanocortin 3 and melanocortin 4, primarily located on the surface of neurons in the brain. These proteins play a central role in regulating feeding behavior and maintaining the body's energy balance.Melanocortin 3 and 4 influence everything from sensing long-term energy stores to processing gut signals about short-term satiety. GLP-1 agonists, such as semaglutides (e.g., Ozempic) and tirzepatides (e.g., Mounjaro), have gained attention for effectively treating type 2 diabetes, obesity, heart disease, and potentially addiction. These drugs mimic a natural hormone produced by the gut when full, signaling the brain to reduce feeding behavior. In the study, researchers tested the effects of several hormones that reduce food intake in the mouse models and discovered that modifying the melanocortin system made mice more responsive to GLP-1 drugs and other hormones influencing feeding behavior. Mice treated with a combination of a GLP-1 drug and an MC4R agonist or MC3R antagonist experienced up to five times more weight loss and reduced feeding compared to those receiving only GLP-1 drugs. The researchers also measured brain activity in areas associated with nausea from GLP-1 drugs and found no increased activation when these drugs were combined with alterations to the melanocortin system. However, priming melanocortin neurons significantly boosted GLP-1 drug activation in hypothalamic feeding centers. The findings suggested that combining GLP-1 drugs with an MC4R agonist could increase the drugs' effectiveness by up to fivefold without enhancing side effects. This approach could allow patients sensitive to side effects to take lower doses or improve outcomes in those unresponsive to current dosages. Further drug development and clinical testing are needed to advance this strategy. Although this research has only been conducted in mouse models, researchers remain optimistic that the results will translate effectively to humans. "The melanocortin system is highly conserved in humans. Everything we've observed in the mouse over the past decades studying these proteins has also been found in humans, so I suspect that these results would also be translatable to patients,” said Cone, director of the U-M Life Sciences Institute Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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Stop Counting Calories Now | Safe Weight Loss in 30 Days | R2M Protocol | Peter Greenlaw For years, we've been taught to meticulously count calories, meticulously monitor our food intake, only to find ourselves frustrated with minimal results. But what if we told you that counting calories not only fails to deliver sustainable weight loss but also puts your health at risk? Recent peer-reviewed studies have shattered the myth of calorie counting, revealing that traditional dieting methods often lead to the loss of precious lean muscle mass, leaving individuals feeling fatigued and demotivated. In these groundbreaking studies, participants—80% women and 20% men—embarked on a non-dieting approach to weight loss. The results were astounding. In just one month, they witnessed transformations that would typically take a year on conventional diets. And here's the kicker: they achieved these results without stepping foot in a gym! Over the course of 30 days, participants not only shed excess weight but also experienced significant improvements in key health markers. From lowered blood pressure, blood sugar, cholesterol, and triglycerides to a remarkable reduction in inflammation by 25%, the evidence speaks volumes. Moreover, in just 8 weeks, participants saw a staggering 33% reduction in visceral fat—a feat unmatched by any conventional diet. But how did they achieve these remarkable results without counting calories or hitting the gym? It all boils down to a simple yet profound principle: Eat Calories That Count, not just any calories. Our bodies crave nourishment, not mere numbers. Imagine your body as a finely tuned machine craving essential nutrients to thrive. When we prioritize nutrient-dense foods over calorie counting, we nourish our bodies from within, fostering sustainable weight loss and vibrant health. Ready to transform your life and revolutionize your weight loss journey? Visit r2mprotocol.com to learn more about the studies, protocols, and how you can embark on your path to success. Don't let another year go by without achieving your weight loss goals. It's time to embrace the power of Protein Pacing and unlock your full potential. Further information: Start your Journey Today: https://thenewhealthconversation.com ************************************************************************ Connect through: YouTube: @TheNewHealthConversation TikTok: @thenewhealthconvesation Website: https://thenewhealthconversation.com ************************************************************************** #WeightLoss #DietingMyths #HealthScience #r2mprotocol #TheNewHealthConversation #health #fitness weight loss in a month weight loss in a month before and after weight loss in a month diet weight loss in a month challenge weight loss in 2 months weight loss procedures weight loss tips weight loss journey truth about weight loss truth about weight truth about weight loss summit 2024 truth about weight gain truth about losing weight truth about ozempic weight loss shocking truth about menopause weight gain the shocking new truth about weight loss the truth about my weight loss the truth about weight loss drug ozempic the truth about weight lifting the truth about weight loss surgery truth about carbs and weight loss diet myths diet myths debunked diet myths after delivery diet myths and facts diet myth tim spector carnivore diet myths carnivore diet myths debunked vegan diet myths keto diet myths and facts keto diet myth diet myths diet myth diet myths debunked diet myths and facts diet myths after delivery carnivore diet myths carnivore diet myths debunked vegan diet myths keto diet myths and facts the carnivore diet myth or miracle

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Jelly Roll’s incredible transformation took center stage at the 2024 CMA Awards as he proudly showed off his 100-lb. weight loss! After battling food addiction, Jelly Roll has truly turned his life around, and his inspiring journey is a testament to his hard work and determination. Watch as he shares his emotional victory and celebrates his success at the CMAs. In this video, we dive into Jelly Roll's powerful weight loss journey, how he overcame his struggles with food addiction, and the impact it's had on his life, both personally and professionally. Don’t miss this motivational moment from one of country music’s most resilient stars! Tags: #JellyRoll #100LbWeightLoss #2024CMAs #WeightLossTransformation #FoodAddiction #JellyRollTransformation #CMAs2024 #InspiringJourney #CountryMusic #JellyRollSuccess #MotivationalStory #OvercomingAddiction #WeightLossJourney #JellyRollCMAs

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Is it GLP-1 agonist or antagonist? That is the question that Matt and Ryan review and discuss. This medication has its positives and negatives that many people don’t seem to realize the negatives prior to taking. Sign up for your free Meet-and-Greet Traffic woes What is “time”? [1:09] Matt’s and Ryan discuss The Flash [1:39] Have you checked out all of our other episodes? [3:47] Matt’s favorite Batman movie [5:23] Movie concessions [7:05] Today’s topic [8:39] Is it a magic pill? Misleading advertising [10:30] When did GLP-1’s come on the market? [11:39] Matt’s number one concern [12:16] Matt’s number two concern [12:32] Conditionally essential supplements episode [12:39] GLP-1’s for fat loss [13:24] What is a GLP-1 anyway? [14:25] StatPearls on GLP-1 Agonist [15:40] Brief primer on diabetes mellitus [16:27] How GLP-1 Agonists work [17:37] The greatest impact to your blood sugar [19:46] The answer to everything [20:39] Sign up for your free Meet-and-Greet [20:56] Average amount of weight of weight loss on GLP-1 [21:25] Reiterating what Matt said earlier [23:28] How does this compare to baseball and steroids? [23:41] Administration of GLP-1’s [24:48] Call back to the movies [26:35] A caloric deficit causes weight loss? [26:56] Side effects of GLP-1 agonist [27:50] The amount of time to lose weight is almost the same as the trial time for GLP-1’s [29:10] What’s your end goal? [30:16] Follow us on social media [31:14] A quote from a doctor [31:38] What are the mental and emotional things that happened [33:50] Our philosophy [36:43] Sign up for your free Meet-and-Greet –Subscribe and share!-- –Book your free Meet-and-Greet today– https://franchisenf.com/#get-started