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Pharmaceutical interventions for weight loss & healthy weight management have become a topic of discussion over the last few months. One of the drugs which has created a spur in the market is GLP-1 RA. & there have been lot of questions “ Should GLP-1 RA be part of the treatment protocol for weight loss?” “ IS GLP-1 an anti-diabetic drug or a weight loss drug?” These questions are specifically coming from weight loss companies who believe that these drugs would have numerous side effects. Therefore, it becomes super important to understand the interaction between gut microbiome & these drugs. We all know that GLP-1 is an incretin hormone secreted by your gut microbiome that plays a key role in regulating satiety & blood sugar response. As such, the drug is being prescribed for glycemic control at present. However, the question still looms around if these drugs in small doses could promote healthy weight management? While this is a grey area, it is important to understand that not only does weight gain increase risk of insulin resistance but also insulin resistance caused by bad fats or functional loss of nitric oxide production could lead to weight gain. This insulin resistance derived weight gain is connected with hypothyroidism. Thyroid is the most essential hormone & our gut microbiome plays an important role in stimulating TSH & converting T4 to T3. Generally T4, the inactive form -T4 is converted into active form T3 with the help of type 2 deiodinase. Insulin resistance reduces the function of this enzyme, preventing the conversion of T4 to T3. This results in low levels of T3 & hence there is less T3 that could dock on the thyroid receptor expressed on cell membrane which disrupts cellular communication & interferes with metabolic activity, leading to weight gain. Controlling the blood sugar response could regulate the thyroid functions & may contribute to healthy weight management To really evaluate the efficacy of GLP-1 RA, it is important to understand the interaction between your gut microbiome & these drugs Citations https://pubmed.ncbi.nlm.nih.gov/17505150/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8793908/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6354569 #weightloss #weightlossjourney #weightlosstips #weightlossdiet #glp1 #glp1medication #glp1support #glp1weightloss #glp1community #obesity #obesitymedicine #obesityawareness #obesityawareness #obesitycontrol #obesityfreeindia #ozempicweightloss #ozempicsideeffects #ozempicjourney

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Findings from a retrospective trial show GLP-1 medications for moderate peripheral artery disease (PAD) significantly decreased the risk of amputations. Dr Catherine Go (Charleston Area Medical Center, Charleston, WV, US) joins us to discuss outcomes from the largest retrospective trial evaluating the impact of GLP-1 medications for patients with moderate PAD. The study used the TriNetX database to identify 55,000 patients who started medication on a GLP-1 receptor agonist and compared them to 55,000 patients who did not start on a GLP-1 receptor agonist, and the patients were followed for one year. Findings showed that GLP-1 receptor agonist treatment in patients with moderate PAD, including in those without diabetes, was associated with lower rates of cardiac events, limb events, hospital admissions and mortality. Interview Questions: 1. What is the importance behind the retrospective trial? 2. What was the study design and patient population? 3. What were the key findings, and were there any unexpected results? 4. What are the take-home messages for practice? 5. What further research is needed in this area, and what are the next steps? Recorded remotely from Charleston, 2025. Editors: Jordan Rance, Yazmin Sadik Videographers: David Ben-Harosh Support: This is an independent interview produced by Radcliffe Vascular. Visit Radcliffe Vascular: https://www.radcliffevascular.com/ This content is intended for healthcare professionals only. Radcliffe brings medical knowledge, insight and innovation to life for CV clinicians around the world, using our communications & creative expertise, our platforms and connections across the community to help transform theory into practice faster. Like us on Facebook: https://www.facebook.com/radcliffe.vascular/ Follow us on X: https://x.com/radcliffeVASCU

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