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TODAY teamed with Dan Buettner to write down recipes from five areas of the world where people are unusually long-lived. When people in one American city went on a Blue Zones diet for three months, the results were dramatic. TODAY special anchor Maria Shriver reports. » Subscribe to TODAY: http://on.today.com/SubscribeToTODAY » Watch the latest from TODAY: http://bit.ly/LatestTODAY About: TODAY brings you the latest headlines and expert tips on money, health and parenting. We wake up every morning to give you and your family all you need to start your day. If it matters to you, it matters to us. We are in the people business. Subscribe to our channel for exclusive TODAY archival footage & our original web series. Connect with TODAY Online! Visit TODAY's Website: http://on.today.com/ReadTODAY Find TODAY on Facebook: http://on.today.com/LikeTODAY Follow TODAY on Twitter: http://on.today.com/FollowTODAY Follow TODAY on Instagram: http://on.today.com/InstaTODAY Follow TODAY on Pinterest: http://on.today.com/PinTODAY #BlueZonesDiet #Diet #TodayShow These People Tried The Blue Zones Diet For 3 Months: See What Happened | TODAY
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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)
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ACV Keto Gummie: The Acid Test for Your Ketosis
Exploring the World of Valiant Keto ACV Gummies
The weight loss industry is constantly evolving, with new products emerging nearly every day. One of the latest trends that has captured the attention of health enthusiasts is the use of Valiant Keto ACV Gummies. These confectionery delights combine the power of apple cider vinegar (ACV) with the ketogenic diet’s benefits to create a supplement that not only aids in weight loss but also appeals to the taste buds. The growing popularity of these gummies can be attributed to their convenience, effectiveness, and the added health benefits associated with both ACV and the ketogenic lifestyle.
Valiant Keto ACV Gummies are specifically designed to support individuals undertaking the ketogenic diet, which prioritizes low-carbohydrate, high-fat food consumption. The idea behind the ketogenic diet is to induce a metabolic state known as ketosis, where the body efficiently burns fat for energy instead of carbohydrates. By incorporating apple cider vinegar into this framework, Valiant Keto ACV Gummies promise enhanced fat-burning capabilities, reduced hunger cravings, and improved metabolic health. These gummies cater not only to those seeking to lose weight but also to individuals looking to maintain a healthier lifestyle.
Customer reviews play a significant role in shaping the perception of any product in today’s market. With over 100 user reviews analyzed, the feedback on Valiant Keto ACV Gummies varies from success stories to recommendations for improvement. Many users rave about the gummies’ taste and their ability to help in achieving health and fitness goals, while others have shared their experiences regarding the gummies’ effectiveness in complementing their weight loss journey. The following sections will delve deeper into the experiences of the users, the ingredients’ efficacy, the associated health benefits, and what potential consumers should know before trying Valiant Keto ACV Gummies.
Customer Feedback: What Users Are Saying
The analysis of over 100 user reviews reveals that Valiant Keto ACV Gummies have captivated a wide audience. Feedback typically centers around taste, effectiveness, and overall satisfaction with the product. Many users highlight that the gummies have a pleasant flavor, which makes them a delightful alternative to traditional supplements, often criticized for their unpleasant aftertaste or difficulty in swallowing. The infusion of apple cider vinegar in a gummy format has allowed users to bypass some of ACV’s more challenging aspects, such as its strong aroma and acidic taste.
Moreover, countless users reported positive effects when it comes to weight loss. Many have documented their journeys of using Valiant Keto ACV Gummies alongside a ketogenic diet, emphasizing how the gummies helped curb their appetite, which ultimately led to reduced caloric intake. A significant number of reviewers noted a decrease in cravings for sugary snacks, allowing them to stick more rigorously to their dietary plans. Users underscore this as one of the key benefits, as managing cravings can often pose a substantial challenge when attempting to lose weight.
On the flip side, some reviews contained constructive criticism regarding the gummies’ effectiveness in promoting weight loss on its own. A few users expressed the sentiment that the gummies didn’t provide miraculous results without proper dietary and exercise habits in place. While most reviews were generally positive, it’s essential to recognize that individual results may vary, and achieving weight loss requires a holistic approach that includes diet, exercise, and lifestyle changes. Overall, the reviews present a mix of excitement and cautious optimism, reflecting a realistic view of the product’s potential benefits and limitations.
Ingredient Breakdown: What’s Inside Valiant Keto ACV Gummies?
Understanding what goes into any dietary supplement is crucial for making informed choices. Valiant Keto ACV Gummies are crafted with a blend of effective ingredients designed to support weight loss and overall health. The primary ingredient, apple cider vinegar, boasts numerous health benefits, including improved digestion, enhanced metabolism, and better blood sugar control. The inclusion of this potent ingredient offers users an easy way to incorporate its properties into their daily routines without the inconvenience associated with traditional liquid ACV.
Additionally, these gummies often contain other supporting components such as B vitamins, which are known to bolster energy levels and support metabolic processes. Such vitamins play an essential role in converting food into usable energy, thereby enhancing the body’s ability to burn fat efficiently. Moreover, these vitamins are crucial for maintaining overall health, making the gummies more than just a weight-loss tool; they also provide a variety of health benefits that assist in the overall wellness journey.
Finally, the gummies are often enriched with natural flavors and sweeteners to improve taste without compromising nutrition. This focus on creating a product that not only acts as a supplement but also tastes good is critical to ensuring adherence to a weight-loss or health regimen. By synthesizing effective ingredients with desirable flavors, Valiant Keto ACV Gummies stand out as a supplement that can deliver results while making the process enjoyable for users.
Health Benefits Beyond Weight Loss
While Valiant Keto ACV Gummies primarily attract users for their weight-loss capabilities, they also present a variety of additional health benefits. The presence of apple cider vinegar in the gummies is noteworthy, as it is associated with enhanced gut health. Many users have reported improved digestion after incorporating ACV into their diets, leading to a reduction in bloating and an increase in overall comfort. With gut health being a cornerstone of physical well-being, these gummies can contribute positively in this area.
Beyond digestion, another significant benefit attributed to the consumption of apple cider vinegar is its potential to regulate blood sugar levels. Studies indicate that ACV can help improve insulin sensitivity and lower blood sugar levels after meals, which is particularly beneficial for those managing diabetes or insulin resistance. By maintaining stable blood sugar levels, users may experience fewer sugar cravings and a more stable energy level throughout the day, contributing to a more productive lifestyle.
Additionally, Valiant Keto ACV Gummies may offer benefits for cardiovascular health. Apple cider vinegar has been linked to improved cholesterol levels and overall heart health. Some users have reported a feeling of well-being and vitality when integrating these gummies into their supplements, highlighting the possible cardiovascular benefits. As heart health remains a vital concern for many, these gummies encapsulate a holistic approach to wellness that extends beyond just weight loss.
Navigating the Path to Success with Valiant Keto ACV Gummies
<pFor potential users keen on integrating Valiant Keto ACV Gummies into their weight-loss journey, it’s essential to have a clear understanding of how to maximize their effectiveness. These gummies are best used in conjunction with a balanced diet and regular exercise. While they can help curb cravings and enhance metabolism, relying solely on the gummies without making dietary changes or incorporating physical activity may yield unsatisfactory results.
Establishing a regular consumption routine can also be beneficial. Users are encouraged to take the gummies consistently, as part of a daily ritual, to reinforce their commitment to their health and wellness goals. Setting specific milestones and tracking progress can enhance motivation and provide a clearer picture of how well the gummies are working in conjunction with other lifestyle changes.
Lastly, surrounding oneself with a supportive community can also aid in the journey. Sharing experiences, challenges, and milestones with friends, family, or a wellness group can provide the encouragement needed to stay on track. Whether through social media, wellness blogs, or local meetups, connecting with others who share similar goals can make a significant difference in sustaining motivation and achieving success with Valiant Keto ACV Gummies.
Addressing Common Questions and Concluding Thoughts
As with any health supplement, potential users often have numerous questions surrounding Valiant Keto ACV Gummies. One of the most frequently asked questions pertains to dosage. Users typically find that taking one or two gummies per day is effective, depending on individual health needs and dietary goals. Consulting with a healthcare provider before starting any new supplement is always recommended, especially for those with existing health conditions or who are on medications.
Another common query relates to any potential side effects associated with the gummies. While most reviews are positive, some users may experience mild digestive discomfort when first introducing apple cider vinegar into their diet. Starting with a smaller dosage and gradually increasing can help mitigate these effects. It is vital to monitor one’s own body and adjust consumption levels accordingly.
In conclusion, Valiant Keto ACV Gummies present a promising option for individuals seeking to enhance their health and weight-loss efforts. The overwhelmingly positive feedback from users, coupled with the quality ingredients, creates a product that caters to the needs of many health-conscious individuals. While results may vary, the amalgamation of taste, convenience, and health benefits makes these gummies a noteworthy addition to personal wellness journeys. To ensure a successful experience, approach their usage as part of a broader dietary and lifestyle plan, and embrace the journey of achieving health goals.
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Unlock the secrets of how to achieve hyperketosis with this focused diet plan for optimal fat burning. Learn how a structured ketogenic approach, enhanced by fasting and smart nutrition, can elevate your metabolism and transform your energy. Whether you're a seasoned keto follower or just getting started, this video breaks down the key strategies for reaching deep ketosis safely and effectively. #hyperketosis #fatburning #ketodietplan See also: https://youtu.be/m2PKIgmh2DA
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