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Excess protein may dramatically increase the risk of cancer and accelerate aging. Dr. Valter Longo, one of the top scientists in aging research and creator of the Fasting Mimicking Diet, explains why the risk is so high. Viva Longevity's mission is to find the most credible scientists and help them tell their stories. PAPERS: Nature: Optimal dietary patterns for healthy aging https://www.nature.com/articles/s41591-025-03570-5 Fasting mimicking diet cycles versus a Mediterranean diet and cardiometabolic risk in overweight and obese hypertensive subjects: a randomized clinical trial by Valter Longo https://www.nature.com/articles/s44324-023-00002-1 Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population https://www.cell.com/cell-metabolism/fulltext/S1550-4131(14)00062-X Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30135-X/fulltext Dietary Amino Acids and Risk of Stroke Subtypes: Results from 3 Large Prospective Cohort Studies https://www.sciencedirect.com/science/article/pii/S0022316625001786 Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2540540 Dietary protein intake in midlife in relation to healthy aging – results from the prospective Nurses’ Health Study cohort https://www.sciencedirect.com/science/article/pii/S0002916523662823 FILM: Fasting and the Longevity Revolution with Valter Longo (awesome): https://www.fastingandthelongevityrevolution.com/ WEBSITES: All things Dr. Longo — books, a documentary, information https://valterlongo.com/ Fasting Mimicking Diet kits (Prolon): https://prolonlife.com/ The Create Cures Foundation (A Longo foundation): https://createcures.org/ Fondazione Valter Longo https://www.fondazionevalterlongo.org/en/ 0:00 Excess protein is dangerous 2:18 Valter Longo's mission & discoveries 8:24 IGF-1's profound role 17:35 Excess animal protein increases cancer risk by 400% 21:15 Foods that increase longevity 32:22 Why is red meat so bad? 37:11 Protein vs carbs 40:36 Plant vs animal protein 46:43 Low carb diets 49:00 Fasting mimicking diets 1:04:22 Cancer and autoimmunity 1:22:17 GLP-1 Ozempic 1:32:52 Protein powder 1:35:30 Chris' takeaways
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Understanding the Keto Diet and Its Relevance to Multiple Sclerosis
The ketogenic diet, often referred to as the keto diet, has gained significant popularity in recent years, particularly among those seeking to manage their weight or improve their overall health. Characterized by a high-fat, low-carbohydrate intake, the diet aims to induce a state of ketosis whereby the body shifts its primary fuel source from carbohydrates to fats. While the keto diet has been widely studied for its impact on conditions such as obesity and type 2 diabetes, its potential applications extend beyond these realms, attracting the attention of individuals grappling with chronic neurological conditions, including Multiple Sclerosis (MS).
Multiple Sclerosis is a complex and often debilitating autoimmune disease where the immune system mistakenly attacks the central nervous system, causing widespread neurological symptoms. The quest for effective dietary interventions for MS is driven by the recognition that nutrition plays a vital role in managing inflammation, neuroprotection, and overall health. Given the potential for the keto diet to modulate metabolic pathways and reduce inflammation, researchers and healthcare professionals have begun to explore its benefits for those living with MS. However, like any other dietary intervention, the keto diet presents both potential advantages and risks, necessitating a balanced examination.
This article aims to explore three potential benefits and risks of the keto diet specifically within the context of Multiple Sclerosis. By focusing on how this dietary approach may influence symptoms, enhance nutritional status, and affect medication efficacy, we aim to provide a comprehensive overview for individuals considering the keto diet. Furthermore, it is crucial to address the risks and challenges associated with this restrictive eating pattern, helping individuals make informed dietary choices in their effort to manage MS effectively. As we delve deeper into this topic, we will consider clinical research findings, anecdotal evidence, and practical implications that can guide decision-making for individuals with MS and their healthcare providers.
Potential Benefits of the Keto Diet for MS: Inflammation and Immune Function
The connection between diet and inflammation is a central theme in the management of Multiple Sclerosis. The keto diet, with its low carbohydrate content, potentially has implications for reducing inflammation. By limiting the intake of glucose, which can exacerbate inflammation, individuals may experience a reduction in the overall inflammatory response within the body. This switch can positively affect symptom management, reducing flare-ups and offering a new avenue for relief to those with MS.
Research indicates that the metabolic state achieved through ketosis may significantly influence immune function. In cases of autoimmune diseases like MS, where the immune system becomes dysregulated, a diet that promotes ketosis can have a balancing effect. Ketogenic diets may encourage the production of ketone bodies, which are not only efficient fuel sources but could also possess anti-inflammatory properties that help modulate immune responses. Such dietary changes may ultimately contribute to longstanding neurological health, benefitting individuals who are often seeking out means to manage their condition more effectively.
In addition to reducing inflammation, the keto diet has the potential to improve mitochondrial function. Mitochondria serve as the powerhouse of cells, including neurons, converting nutrients into energy. A dysfunctional energy metabolism is a noted characteristic of several neurological diseases, including MS. By providing an alternative substrate for energy production—specifically ketones—the ketogenic diet may promote better energy availability for neural tissues. This improvement could enhance cognitive function and overall neurological integrity, which are critical components for those affected by MS.
Exploring Neurological Protection: The Role of Ketones in MS
One of the intriguing aspects of the ketogenic diet is the way in which ketones may provide neuroprotective benefits, potentially altering disease trajectories in MS. Ketones, such as beta-hydroxybutyrate, are known to exert neuroprotective effects on brain cells through various mechanisms, including reducing oxidative stress and inflammation. This neuroprotection could be crucial for individuals with MS, who often experience degeneration of neurons as a result of the disease.
Additionally, the ketogenic diet may promote autophagy, a cellular cleaning process that removes damaged components within cells. In the context of MS, enhancing autophagy through a ketogenic approach could help in mitigating cellular damage and promoting cellular repair mechanisms. By clearing out waste products, the brain could function more efficiently, potentially restoring some of the lost capabilities in affected individuals and contributing to an improved quality of life.
Furthermore, research suggests that the ketogenic diet may enhance synaptic plasticity, a vital process for learning and memory involving the strengthening or weakening of synapses. For individuals with MS, the enhancement of synaptic plasticity could relate to improved neurological function, reframing how the disease is experienced daily. The cumulative benefits of these outcomes may significantly affect the overall prognosis and lifestyle management strategies for individuals living with MS.
The Challenge of Dietary Adoption: Practical Risks of the Keto Diet
While the potential benefits of the ketogenic diet for MS are compelling, the adoption of this high-fat, low-carbohydrate eating pattern presents distinct practical risks that must be acknowledged. First and foremost is the risk of nutritional deficiencies. Transitioning to a keto diet often requires significant changes in food choices, which can lead to the reduction of food groups, especially fruits and whole grains that are typically rich in vitamins, minerals, and fiber. This limitation may lead to deficiencies that can further complicate an already complex condition like MS.
Another critical risk is the initial adaptation phase, commonly referred to as the “keto flu.” During this phase, individuals may experience flu-like symptoms, including headaches, fatigue, and nausea, as their bodies adjust to processing fats for fuel instead of carbohydrates. For someone managing MS, experiencing additional symptoms during this transitional phase can exacerbate their condition and undermine their motivation to stick with the diet. Understanding and anticipating these challenges may help individuals better prepare for and navigate the initial adjustment period.
Compliance and sustainability of the keto diet also present significant challenges. The restrictive nature of the diet can lead to feelings of deprivation, which might result in episodes of binge eating or relapse into previous eating habits. For individuals with MS who may already be facing diverse challenges in self-management, maintaining adherence to such a stringent dietary program could become overwhelming and counterproductive. It is essential for both healthcare providers and individuals to consider how sustainable these dietary changes are in the long term.
Medication Interactions and Impact on Treatment: Navigating the Risks
Another layer of complexity in exploring the keto diet for individuals with MS is the potential interactions with prescribed medications. Many individuals with MS take medications that may significantly depend on patient nutrition to achieve optimal efficacy. Changes in dietary patterns, particularly macronutrient ratios and caloric intake, can potentially alter the way certain medications are absorbed or metabolized. Therefore, it’s crucial for individuals navigating dietary changes to maintain open communication with their healthcare providers to ensure a well-coordinated approach in managing their condition.
The ketogenic diet may also influence the effectiveness of certain disease-modifying therapies used to manage MS. Some treatments operate by influencing metabolic pathways that the keto diet itself also affects. Consequently, individuals following a ketogenic approach may need to be closely monitored by their healthcare team to detect any shifts in their symptom management or potential alterations in medication effectiveness.
A fundamental aspect of addressing these interactions lies in understanding the dose-response relationship of dietary fat as it pertains to drugs. Individuals with MS must consider how the increased intake of saturated fats from the keto diet may impact cholesterol levels and cardiovascular health over time, raising concerns about the potential need for dosage adjustments in certain medications. Evaluating these medications in conjunction with dietary choices is vital to achieving long-term health and wellness in individuals with MS.
Addressing Common Questions and Considerations for Individuals with MS
In considering the keto diet for Multiple Sclerosis, individuals often have numerous questions regarding its safety and efficacy. One of the most common inquiries is whether the keto diet can replace conventional medical therapies. While some may experience benefits that lead to noticeable symptom relief, it is important to recognize that dietary approaches should complement, rather than replace, a physician-approved treatment regimen. The integration of proper nutritional practices alongside prescribed medications can create a synergistic effect, enhancing overall management and improving health outcomes.
Another prevalent concern involves the long-term sustainability of the keto diet, particularly in relation to social interactions and lifestyle factors. Individuals with MS may find that strict adherence to such a diet complicates social dining experiences, travel, and family meals. Creative adaptations and open dialogues with friends and family can help mitigate these social barriers, permitting individuals to retain a sense of normalcy in their dietary practices while still prioritizing their health.
Finally, the importance of individualized dietary guidance cannot be overstated. Each person with MS presents a unique clinical picture, influenced by factors such as age, severity of the disease, and other comorbid conditions. Consulting with a registered dietitian, who can provide tailored advice, can enable individuals to bridge the gap between dietary theory and practical implementation. By promoting adaptive eating patterns and developing meal plans that consider personal preferences and nutritional needs, individuals are more likely to thrive on dietary interventions such as the keto diet while effectively managing their MS.
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Calorie Calculator Link : https://www.inchcalculator.com/harris-benedict-calculator/ 📩 Online Coaching : [email protected] Wondering why are you not gaining any weight? Could genetics be a reason? Or is it just your body type? How can you gain more weight? I'm here to answer all of these questions and then some to help you through your weight gain Journey so you can achieve your ideal body goal in a healthy and natural way! Gaining weight is often a massive challenge for many people, however, it is nothing that a healthy diet, workout, and a few lifestyle changes can't fix. In this video, I am sharing with you some of the major reasons that might be causing you to lose weight along with a set of tips and recommendations that you can include in your everyday routine to help with weight gain issues. Topics Discussed in the video include Body Type, Diet, Meal Portions, low fiber foods, and high fiber foods, Protein, Calories, Carbohydrates, Workout Volume, Workout Frequency, Workout Length, Strength gain, Recovery after a workout, Sleep time, Stomach Health, Eating Disorders, Indigestion, and more! By the end of this video, you will be fully prepared and aware to begin your weight gain journey so don't forget to share your progress with me! If you’re underweight and looking to gain weight, it’s very important to do it right. Consuming soda, donuts, and other junk foods may help you gain weight initially, but it can increase your risk of heart disease, diabetes, and cancer . A healthier approach to gaining weight involves gaining a balanced amount of muscle mass and subcutaneous fat rather than a lot of unhealthy belly fat . A recent animal study suggests that belly fat specifically may be correlated with increased cancer risk A high percentage of body fat also increases your chances of developing type 2 diabetes and other health problems, even if you are not overweight . To gain weight healthily, focus on eating more nutrient-dense foods and living an overall healthy lifestyle that involves exercising, getting enough sleep, and reducing stress, if you can. This article outlines simple strategies to quickly gain weight — without increasing your risk of disease. Although being lean can often be healthy, being underweight can be a concern if it's the result of poor nutrition or if you are pregnant or have other health concerns. So, if you're underweight, see your doctor or dietitian for an evaluation. Together, you can plan how to meet your goal weight. Here are some healthy ways to gain weight when you're underweight: Eat more frequently. When you're underweight, you may feel full faster. Eat five to six smaller meals during the day rather than two or three large meals. People can gain weight in several ways. The simplest method is to increase the overall calorie intake while focusing on eating a variety of food groups. Individuals who specifically want to gain muscle can combine this higher calorie intake with sufficient protein and exercise. Note that being underweight (or overweight) is not always solely measured by BMI, and there are other factors to consider.8 Some people naturally have less fat than others and could be perceived as underweight due to their low BMI but are otherwise perfectly healthy. The same goes for those who may be considered overweight or obese based on their BMI. That's why it's best to speak with your doctor who can provide an accurate diagnosis. If you're underweight and it's determined that your health would benefit from gaining weight, your doctor will likely recommend that you eat more foods that are nutrient- and calorie-dense to help you gain weight. But at the same time, there are many people struggling with weight gain. Gaining weight is not strenuous. How to Gain Weight at Home in 7 Days Here we create a list of tips that can help you to gain within a week naturally without creating health issues. Try to follow these weight gain diet tips and the result will start showing within 7 days: 1. Eat a lot of proteins: Protein forms the building blocks of your muscles. Eating sufficient protein is required to gain muscle weight instead of just fat. If you're trying to gain weight, aim for 0.7-1 grams of protein per pound of body weight (1.5 - 2.2 grams of protein per kilogram). 2. Eat Repeat Eat: Eat at least 3 meals per day and make sure to eat plenty of fat and carb. 3. Energy Dense Food for weight gain: Eat a lot of energy-dense food. Nuts: Almonds, walnuts, macadamia nuts, peanuts, etc. Dried fruit: Raisins, dates, prunes, and others. High-fat dairy: Whole milk, full-fat yogurt, cheese, cream. Fats and Oils: Extra virgin olive oil and avocado oil. Grains: Whole grains like oats and brown rice. Meat: Chicken, beef, pork, lamb, etc. Choose fattier cuts. 4. Weight Lifting Exercise: Lift heavy weights and improve your strength. This will help you gain muscle mass instead of just fat.
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