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Get My Book On Amazon: https://a.co/d/avbaV48 Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/ Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/ 👉Join The Fully Optimized Health Private Membership Group: https://www.fullyoptimizedhealth.com/start-here 1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/ Book A Call With Me: https://hunterwilliamscall.carrd.co/ Supplement Sources: https://hunterwilliamssupplements.carrd.co/ Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY Socials: Instagram: https://www.instagram.com/hunterwilliamscoaching/ Podcast: https://hunterwilliamspodcast.buzzsprout.com/ Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/ In this video, I dive deep into the reasons behind the infamous “GLP plateau”—that frustrating point where fat loss on GLP-1 peptides like semaglutide, tirzepatide, and retatrutide comes to a grinding halt. I break down the physiological, hormonal, and lifestyle factors that drive plateaus, plus practical, science-backed solutions to get results moving again. If you’re struggling with stalled progress, this is the most comprehensive breakdown you’ll find on how to identify, understand, and push through GLP plateaus. Let’s break it all down step by step: ⸻ Timestamps 0:00 – Introduction: Why Do GLP-1 Plateaus Happen? 0:35 – Why Weight Loss Plateaus Are Universal 1:22 – How GLP-1s Work (Mechanisms: Semaglutide, Tirzepatide, Retatrutide) 2:36 – Typical Weight Loss Trajectory on GLP-1s 3:18 – When (and Why) Most People Plateau 4:55 – Plateau ≠ Failure: The New Weight Set Point 5:39 – Physiological & Metabolic Causes of Plateaus 6:26 – Resting Metabolic Rate Drop & Adaptive Thermogenesis 7:31 – Decreased Thermogenesis, Exercise Efficiency, & Mitochondria 8:42 – Muscle Loss and Its Impact on Plateaus 9:44 – NEAT (Non-Exercise Activity Thermogenesis) Drops 10:18 – Why the Body Adapts: Our Ancestral Survival Mechanism 11:06 – Hormonal Adaptations: Leptin, Ghrelin, Insulin 13:03 – Leptin Drop: Increased Hunger, Lower Metabolism 13:41 – Ghrelin Rise: Appetite Returns 15:17 – Insulin, Metabolic Health & Fat Loss 17:20 – Thyroid Hormones: T3, Metabolic Rate, and the Plateau 19:03 – Cortisol, Stress, and Fat Storage 20:07 – Sex Hormones: Testosterone, Fat Loss, and Plateaus 21:46 – Amylin, Neuropeptide Y, and Brain Pathways 22:44 – Behavioral & Lifestyle Factors: NEAT, Adherence, Calorie Creep 24:44 – Psychological Fatigue, Sleep, Diet Quality, & Hydration 28:27 – Is It a True Plateau? Body Fat vs. Weight Loss 28:32 – Pharmacological Tolerance & Dosing Issues 30:00 – Appetite Pathways and Receptor Desensitization 31:52 – Dose Ceiling: When More Isn’t Always Better 33:26 – Strategies to Break Through a Plateau 34:16 – Re-evaluating Diet: Macros, Sugar Diet, and Tracking 34:45 – Activity, Resistance Training, and NEAT 35:03 – Sleep, Stress, Thyroid, and Other Medications 35:44 – Add-On Pharmacology: LDN, Cagrilintide, Leptin Analogs 37:01 – Mitochondrial Pathways: BAM15, SLU-PP-332, Carnitine 37:50 – Cycling, Refeeds, and Metabolic Resensitization 39:55 – Fasting, Intermittent Fasting, and Nutrition 40:08 – Recap: Everyone Plateaus—How Will You Respond? 41:02 – Thank You & Outro

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@East-Bound's personal recount of case: https://youtu.be/7BpymtR2vpA @East-Bound Interview: https://youtu.be/o15HCjtSkug @chubbyemu video on this case: https://youtu.be/ChPeG19qKUo @HemeReview Podcast version: https://anchor.fm/chubbyemu 2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss in the United States. It is a classic case of efficacy, but without safety in the setting of weight loss. This setting of weight loss can be prone to chemical misuse, further exacerbating understanding in human systems. Christopher is one of 2 - 3 cases documented in literature to have survived an accident with DNP for weight loss. As of 2021, one organization has permission from the US FDA to investigate DNP in some neurodegenerative disorders. These are rare diseases with limited standards of care, therefore extenuating circumstances to find anything that could potentially improve patient outcomes. Tweet me: https://www.twitter.com/hemereview IG me: https://www.instagram.com/hemereview FB me: https://www.facebook.com/hemereview References: Role of dantrolene in dinitrophenol (DNP) : A continuing question? Am J Emerg Med. 2019 Jun;37(6):1216.e1-1216.e2. https://pubmed.ncbi.nlm.nih.gov/30948257/ 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity . J Med Toxicol. 2011 Sep;7(3):205-12. https://pubmed.ncbi.nlm.nih.gov/21739343/ Ambient temperature and mortality from unintentional . JAMA. 1998 Jun 10;279(22):1795-800. https://pubmed.ncbi.nlm.nih.gov/9628710/ Dinitrophenol as a Medicine. Cells. 2019 Mar; 8(3): 280. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468406/ The Interaction of Highly Active Uncouplers With Mitochondria. Biochimica et Biophysica Acta, 639 (1981) 225-242. Beware the yellow slimming pill: fatal 2,4-dinitrophenol. BMJ Case Rep. 2016 Apr 4;2016. https://pubmed.ncbi.nlm.nih.gov/27045052/ Dantrolene is not the answer to 2,4-dinitrophenol poisoning: more heated debate. BMJ Case Rep. 2018 Dec 19;11(1):e225323. https://pubmed.ncbi.nlm.nih.gov/30573533/ The effect of 2,4-dinitrophenol on adipose-tissue metabolism. Biochem J. 1969 Feb;111(4):431-44. https://pubmed.ncbi.nlm.nih.gov/4388239/ The mechanism of uncoupling of oxidative phosphorylation by 2,4-dinitrophenol. J Biol Chem. 1967 Oct 25;242(20):4577-83. https://pubmed.ncbi.nlm.nih.gov/4964808/ MECHANISMS OF DINITROPHENOL TOXICITY. Simon E.W. Biological Reviews. Vol 28. (4). Nov 1953. Identification and Importance of Brown Adipose Tissue in Adult Humans. https://www.nejm.org/doi/full/10.1056/NEJMoa0810780 Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev. 2001 Nov;2(4):255-65. https://pubmed.ncbi.nlm.nih.gov/12119996/ LC-MS-MS analysis of 2,4-dinitrophenol and its phase I and II metabolites. J Ana Toxicol. Jan-Feb 2007;31(1):55-61. https://pubmed.ncbi.nlm.nih.gov/17389084/ Uncouplers of oxidative phosphorylation. Environ Health Perspect. 1990 Jul;87:213-8. https://pubmed.ncbi.nlm.nih.gov/2176586/ Texas Woman Charged with Selling Misbranded https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/press-releases/texas-woman-charged-selling-misbranded-drug

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Welcome to Episode 1 of The Take It Back Method — where we finally tell the truth about weight loss. In this episode, Joseph Debban FNP, certified by the Obesity Medicine Association and a national committee member, breaks down why most people fail to lose weight — and how to fix it for good. We’ll expose the two most common (and broken) approaches in medicine today: the “just use willpower” crowd and the “just take a shot and go home” crowd. Then, we’ll walk you through the real solution — the Take It Back approach to metabolic reset. In this episode, you’ll learn: Why insulin resistance, thyroid issues, PCOS, and hormone imbalances often go undiagnosed The simple structure behind the Debban Diet (and why it works when others don’t) How medications like Contrave, Qsymia, and GLP-1s fit into a real long-term plan Why muscle is medicine (and what’s coming in the next episode) The truth about set point theory — and why weight regain is not your fault This isn’t just another weight loss podcast. This is a revolution in how we reclaim health, energy, and vitality — one pillar at a time. Subscribe, share, and follow — and let’s Take It Back together. #weightloss #takeitbackmethod #obesitymedicine #metabolichealth #GLP1 #debbandiet #hormonetherapy #wellness #fatloss #healthspan

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