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#diabetes #weightloss #diabetesdrug Research Reveals Method to Improve Diabetes and Weight-Loss Drug Performance According to new research from the University of Michigan, a network of proteins found in the central nervous system could be leveraged to enhance the effectiveness and minimize the side effects of popular diabetes and weight-loss medications. The study, published in the Journal of Clinical Investigation, focused on two proteins, melanocortin 3 and melanocortin 4, primarily located on the surface of neurons in the brain. These proteins play a central role in regulating feeding behavior and maintaining the body's energy balance.Melanocortin 3 and 4 influence everything from sensing long-term energy stores to processing gut signals about short-term satiety. GLP-1 agonists, such as semaglutides (e.g., Ozempic) and tirzepatides (e.g., Mounjaro), have gained attention for effectively treating type 2 diabetes, obesity, heart disease, and potentially addiction. These drugs mimic a natural hormone produced by the gut when full, signaling the brain to reduce feeding behavior. In the study, researchers tested the effects of several hormones that reduce food intake in the mouse models and discovered that modifying the melanocortin system made mice more responsive to GLP-1 drugs and other hormones influencing feeding behavior. Mice treated with a combination of a GLP-1 drug and an MC4R agonist or MC3R antagonist experienced up to five times more weight loss and reduced feeding compared to those receiving only GLP-1 drugs. The researchers also measured brain activity in areas associated with nausea from GLP-1 drugs and found no increased activation when these drugs were combined with alterations to the melanocortin system. However, priming melanocortin neurons significantly boosted GLP-1 drug activation in hypothalamic feeding centers. The findings suggested that combining GLP-1 drugs with an MC4R agonist could increase the drugs' effectiveness by up to fivefold without enhancing side effects. This approach could allow patients sensitive to side effects to take lower doses or improve outcomes in those unresponsive to current dosages. Further drug development and clinical testing are needed to advance this strategy. Although this research has only been conducted in mouse models, researchers remain optimistic that the results will translate effectively to humans. "The melanocortin system is highly conserved in humans. Everything we've observed in the mouse over the past decades studying these proteins has also been found in humans, so I suspect that these results would also be translatable to patients,” said Cone, director of the U-M Life Sciences Institute Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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Top 10 Common Side Effects of Metformin (And How to Handle Them) If you're taking metformin for type 2 diabetes, you're not alone — it’s one of the most prescribed medications worldwide. While it’s incredibly effective at lowering blood sugar and improving insulin sensitivity, metformin can come with a few side effects, especially when you're just starting out. Wondering what to expect? Here are the 10 most common side effects of metformin, plus tips to manage them like a pro. 1. Nausea Feeling queasy after taking metformin? You’re not alone. Nausea is super common, especially when starting treatment. 👉 Quick Fix: Always take it with food, and start with a low dose. 2. Diarrhea Metformin can speed up digestion, sometimes a little too much. 💡 Pro Tip: Ask your doctor about switching to extended-release metformin (XR) if diarrhea doesn’t ease up. 3. Stomach Cramps & Bloating That gassy, crampy feeling? Totally normal at first. 🍽️ Fix it fast: Avoid greasy or spicy foods and eat smaller meals. 4. Metallic Taste A weird, bitter taste in your mouth after taking metformin? Yep, it’s a thing. 😬 Solution: Stay hydrated, chew sugar-free gum, or suck on mints. 5. Loss of Appetite Metformin can help reduce appetite — sometimes too well. 📉 What to watch for: If you’re losing too much weight or skipping meals often, talk to your doctor. 6. Vitamin B12 Deficiency (Long-Term) Over time, metformin can lower your B12 levels — which can cause fatigue, nerve issues, and memory problems. 🧪 Simple solution: Get regular blood tests and supplement if needed. 7. Headaches New to metformin and feeling a little headachy? 💧 Try this: Stay hydrated, eat regularly, and monitor your blood sugar. 8. Fatigue or Weakness Low energy on metformin? Could be due to B12 deficiency, low blood sugar, or digestive issues. 💬 Check in: If it lasts more than a few days, ask your doctor to run some tests. 9. Lactic Acidosis (Rare but Serious) This is very rare — but serious. Know the warning signs: deep breathing, muscle pain, confusion, and extreme fatigue. 🚨 Act fast: Seek emergency help if you notice these symptoms, especially if you have kidney issues or drink heavily. 10. Low Blood Sugar (When Combined with Other Meds) Metformin alone usually won’t drop your blood sugar too low — but when combined with insulin or other diabetes meds, it can. 🍬 Keep safe: Monitor blood sugar and carry a quick source of glucose just in case. When to Call Your Doctor Don’t tough it out — contact your provider if you experience: Persistent nausea, diarrhea, or fatigue Tingling in hands or feet Memory issues Symptoms of lactic acidosis How to Make Metformin Easier on Your Body ✔️ Take it with food ✔️ Start low, go slow ✔️ Try extended-release if needed ✔️ Stay hydrated and avoid alcohol ✔️ Monitor B12 levels Final Thoughts Metformin is a game-changer in managing type 2 diabetes — and most side effects are temporary and manageable. The key? Know what to expect, listen to your body, and stay in touch with your healthcare provider. Have you had side effects on metformin? Drop a comment below and share your tips — someone else might really benefit from your experience! Medical disclaimer: Medinaz Academy does not provide medical advice. The content available in our books and videos, on our website, or on our social media handles do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. We intend to provide educational information only. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition. #shortsfeed #diabetes #metformin #bloodsugar #health #latestnews

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