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Semaglutide is a medication that has been approved by the Food and Drug Administration (FDA) for the treatment of type 2 diabetes. It belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists, which work by increasing insulin secretion and reducing glucagon secretion in the body. In recent years, there has been growing interest in the potential of semaglutide for weight loss in patients who are overweight or obese. Studies have shown promising results, leading to increased attention on the FDA approval status of semaglutide for weight loss.

Current FDA Approval Status

As of now, semaglutide is not yet FDA-approved for weight loss. However, it has been approved for the treatment of type 2 diabetes at a lower dose under the brand name Ozempic. The FDA is currently reviewing data from clinical trials of semaglutide at higher doses for weight loss. These trials have shown that semaglutide can lead to significant weight loss in patients who are overweight or obese. If the FDA approves semaglutide for weight loss, it would be a groundbreaking development in the field of obesity treatment.

Clinical Trials

Several clinical trials have been conducted to evaluate the efficacy and safety of semaglutide for weight loss. One of the most notable studies is the STEP program, which consists of four phase 3 trials involving over 4,500 participants. The results of these trials have been promising, with participants who received semaglutide experiencing greater weight loss compared to those who received a placebo. In addition to weight loss, semaglutide has been shown to improve other markers of health, such as blood pressure and cholesterol levels.

Mechanism of Action

Semaglutide works by mimicking the effects of a hormone called GLP-1, which is naturally produced in the body. GLP-1 helps regulate blood sugar levels and appetite, making it a promising target for weight loss treatment. By activating GLP-1 receptors in the body, semaglutide can decrease appetite, increase feelings of fullness, and slow down gastric emptying, all of which can contribute to weight loss. This mechanism of action sets semaglutide apart from other weight loss medications on the market.





Potential Side Effects

Like any medication, semaglutide can cause side effects in some patients. Common side effects include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to improve over time as the body adjusts to the medication. In clinical trials, serious side effects were rare, but some patients did experience pancreatitis and gallbladder problems. It is important for patients considering semaglutide for weight loss to discuss the potential risks and benefits with their healthcare provider.

Future Implications

If the FDA approves semaglutide for weight loss, it could have significant implications for the treatment of obesity. Currently, there are limited options available for long-term weight loss, and many patients struggle to maintain weight loss with diet and exercise alone. Semaglutide offers a new approach to weight loss that targets the underlying hormonal imbalances in obesity. With further research and clinical experience, semaglutide could become a valuable tool in the fight against obesity and its associated health risks.

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In conclusion, the FDA approval status of semaglutide for weight loss is currently pending, with promising results from clinical trials. Semaglutide has shown potential for significant weight loss in patients who are overweight or obese, making it a promising candidate for FDA approval. As more data becomes available, healthcare providers and patients alike will have a better understanding of the benefits and risks of using semaglutide for weight loss.

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This Marry Me Melting Cabbage is a warm, feel-good dish that’s perfect for fat-burning and gut-loving goals! Cabbage is low in calories but high in fiber and antioxidants, making it a superstar for digestion and bloating. Olive oil brings in healthy fats that support heart health and help absorb fat-soluble nutrients. Greek yogurt adds a creamy touch while delivering protein and probiotics to nourish your gut and keep you full. Dijon mustard and apple cider vinegar give the sauce a tangy kick that helps boost metabolism and curb cravings. Nutritional yeast adds a cheesy flavor with a dose of B vitamins for natural energy. Topped with parsley for freshness and optional toasted nuts for crunch and extra healthy fats, this dish is light, satisfying, and full of clean, natural goodness. Eat smart. Burn fat. Feel your best. Preheat your oven to 400°F (200°C) and lightly grease a large baking dish. Arrange the cabbage wedges in a single layer, cut side up. Drizzle with olive oil and sprinkle with salt, pepper, smoked paprika, garlic powder, and red pepper flakes if using. Pour the vegetable broth into the bottom of the dish, around the cabbage (not on top). Cover tightly with foil and bake for 40 minutes. While the cabbage bakes, whisk together the Greek yogurt, Dijon mustard, nutritional yeast, and apple cider vinegar in a small bowl to create the creamy “Marry Me” sauce. After 40 minutes, remove the foil and spoon a generous amount of the sauce over each cabbage wedge. Return to the oven uncovered and bake for another 15 to 20 minutes, until the cabbage is golden and tender. Remove from the oven and sprinkle with fresh parsley and toasted pine nuts or almonds for a flavorful finish. Serve warm and enjoy every melt-in-your-mouth bite. Subscribe now and start your healthy journey — one bite at a time! 🍴🔥 🍴 Eat to Lose https://youtube.com/@EattoLose 🥤 Drink to Lose https://youtube.com/@DrinktoLose 🍴🥤 Eat & Drink to Lose https://youtube.com/@EatDrinktoLose ⚠️ Disclaimer All content on Eat to Lose is for informational purposes only. It is not medical advice. Always consult a healthcare professional before making any changes to your diet, lifestyle, or health routine.

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Get a free 2 week trial of MacroFactor here: http://bit.ly/jeffmacrofactor In this video I'm breaking down several potential strategies for "boosting metabolism". We'll discuss drinking more water, green tea, spicy foods, sauna, ice baths, reverse dieting, meal frequency, weighted vests, gaining muscle mass, and cardio. Along the way, we will categorize these based on if they “work”, “might work”, or “probably don't work”. ------------------------------- ** My Fundamentals Training Program: https://shop.jeffnippard.com/product/fundamentals-hypertrophy-program/ ** MacroFactor Diet App: http://bit.ly/jeffmacrofactor [FREE 2 week trial] ** My Ultimate Guide To Body Recomposition: https://shop.jeffnippard.com/product/the-ultimate-guide-to-body-recomposition/ ** MASS (Monthly Research Review): https://bit.ly/jeffMASS ** Rise Gym Apparel: https://rise.ca/jeff ** PEScience Supplements: https://www.PEScience.com/discount/jeff ** Instagram: https://instagram.com/jeffnippard ------------------------------- Categories: 0:00 - Intro 0:42 - What is metabolism? 2:47 - Drinking more water 3:58 - Green tea 4:39 - Spicy food (capsaicin) 5:47 - Sauna 6:18 - Ice baths 6:50 - Building muscle 7:43 - Reverse dieting 8:41 - Meal frequency 9:33 - Cardio 10:49 - Weighted vests 11:53 - Slow dieting 12:15 - NEAT smuggling 12:35 - Weight loss success ------------------------------- References: Variability in Daily Energy Expenditure: https://pubmed.ncbi.nlm.nih.gov/34385400/ Green Tea: https://pubmed.ncbi.nlm.nih.gov/33671139/ https://pubmed.ncbi.nlm.nih.gov/17906192/ https://pubmed.ncbi.nlm.nih.gov/10584049/ https://pubmed.ncbi.nlm.nih.gov/19445822/ https://pubmed.ncbi.nlm.nih.gov/20372175/ https://pubmed.ncbi.nlm.nih.gov/25740906/ https://pubmed.ncbi.nlm.nih.gov/24299662/ Spicy Foods: https://pubmed.ncbi.nlm.nih.gov/28001433/ Sauna: https://pubmed.ncbi.nlm.nih.gov/7743620/ Ice Baths: https://pubmed.ncbi.nlm.nih.gov/10751106/ Reverse Dieting: https://macrofactorapp.com/reverse-dieting/ Meal Frequency: https://pubmed.ncbi.nlm.nih.gov/22719910/ https://pubmed.ncbi.nlm.nih.gov/26024494/ Weighted Vest: https://pubmed.ncbi.nlm.nih.gov/29279372/ https://weightology.net/the-use-of-weighted-apparel-during-contest-prep/ Energy Expenditure and Weight Loss Success: https://pubmed.ncbi.nlm.nih.gov/35013190/ ------------------------------- Filmed by Matt Dziadecki https://www.instagram.com/dziadecki/ Edited by Jeff Nippard Music by Bankrupt Beats: https://www.youtube.com/watch?v=xUCZTjMJr2k ------------------------------- About me: I'm a Canadian natural pro bodybuilder and internationally-qualified powerlifter with a BSc in biochemistry/chemistry and a passion for science. I've been training for 15 years drug-free. I'm 5'5 and fluctuate between 160 lbs (lean) and 180 lbs (bulked). ------------------------------- Disclaimers: Jeff Nippard is not a doctor or a medical professional. Always consult a physician before starting any exercise program. Use of this information is strictly at your own risk. Jeff Nippard will not assume any liability for direct or indirect losses or damages that may result from the use of information contained in this video including but not limited to economic loss, injury, illness or death.

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Dr. Mejia is back with important information regarding GLP-1 medications! He's sharing the latest news about fasting before surgery if you take medications like ozempic or tirzepatide. Patient safety is the top priority! If you're currently using GLP-1 medications like Semaglutide or Tirzepatide for weight loss or blood sugar control, I want to share an important new update that can help keep you safe during any upcoming medical procedures." A new consensus statement, published in the British Journal of Anesthesia and co-sponsored by the American Association of Clinical Endocrinology, now recommends That you should fast from solid food for at least 24 hours before going under anesthesia—even for a routine procedure. That you should only stick to clear liquids during this time. And that you can continue your GLP-1 medication if you’re tolerating it well. So, Why do you need to fast for 24 hours before anesthesia? As you all know, GLP-1 medications slow gastric emptying to help with weight loss and blood sugar control. However, that same effect can leave food in your stomach longer. If you go under anesthesia with undigested food present, you may be at increased risk of aspiration—a serious complication. These new guidelines were based on a comprehensive review of 112 studies and developed using a rigorous consensus method. As lead author explains: “Fasting times are the most important factor to reduce the risk of residual gastric content in patients on GLP-1s.” So the bottom line is this: If you're scheduled for a procedure that requires anesthesia, you do not have to stop your GLP-1 if you are tolerating them well, but be sure to fast from solids for 24 hours, and only consume clear liquids.