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Mic drop, Rebel. So many of us have experienced moments like this one. Let’s all agree to take inspo from Rebel and be done: Done laughing off people’s hurtful comments; done thinking that our bodies have anything to do with our talents; done putting ourselves into a box based on our size; done surrounding ourselves with people who don’t believe in us. Watch the full segment on our page.

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HRS 25 - TRANSFORM-AF shows patients with atrial fibrillation and obesity treated with a GLP-1 RA experienced a reduction in atrial fibrillation (AF)-related events. We are joined by Dr Varun Sundaram (Case Western Reserve University, US) to discuss the findings from the TRANSFORM-AF Study, which aimed to determine whether GLP-1 RAs could reduce the burden of AF in patients with both AF and obesity. The study enrolled 2510 patients from Veteran Affairs medical centers across the United States. Interview Questions: 1. What is the importance of this study? 2. What was the study design and patient population? 3. What are your key findings? 4. What are the key take-home messages for clinicians? 5. What research questions remain, and what are the next steps? Recorded remotely from Ohio, 2025. Visit Radcliffe Cardiology: https://www.radcliffecardiology.com/ This content is intended for healthcare professionals only. Radcliffe brings medical knowledge, insight and innovation to life for CV clinicians around the world, using our communications & creative expertise, our platforms and connections across the community to help transform theory into practice faster. Like us on Facebook: https://www.facebook.com/RadcliffeCardiology Follow us on X: https://x.com/radcliffeCARDIO

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Patient in this case is @East-Bound (check out his YouTube Channel!) @chubbyemu video of this case: https://www.youtube.com/watch?v=ChPeG19qKUo Christopher's recount of his case: https://www.youtube.com/watch?v=7BpymtR2vpA Audio podcast for Heme Review: https://anchor.fm/chubbyemu Tweet me: https://www.twitter.com/hemereview IG me: https://www.instagram.com/hemereview FB me: https://www.facebook.com/hemereview Timestamps: 0:00 - Introduction 0:30 - Can you tell me about yourself? 1:21 - How did you get into lifting weights? 3:14 - Bernard talking about his high school experience 4:12 - What was your relationship like with the gym? 5:48 - How did things change in Christopher's life at the end of high school? 8:17 - Other people's perception of weight 9:24 - Christopher describing long time girlfriend cheating on him 10:32 - People judging others based on weight 14:45 - How did you get back in to fitness during college? 17:54 - Weight loss plateau 20:54 - Weight loss supplements 24:46 - Transition from supplements to harder weight loss chemicals 31:04 - What is clenbuterol like? 33:40 - How did you come across DNP? 35:41 - What is being on DNP like? 40:00 - How long did you take DNP for? 44:58 - What do you remember from day of accident? 50:19 - Tales from the emergency room, September 3 2015 51:10 - Waking up in the ICU 55:25 - How did the accident change your relationship with the gym? 57:54 - What would you tell someone thinking of taking DNP today? 2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss. It is a classic case of efficacy, but without safety in the setting of weight loss. This setting of weight loss can be prone to chemical misuse, further exacerbating understanding in human systems. Christopher is one of 2 - 3 cases documented in literature to have survived an accident with DNP for weight loss. As of 2021, one organization has permission from the US FDA to investigate DNP in some neurodegenerative disorders. These are rare diseases with limited standards of care, therefore extenuating circumstances to find anything that could potentially improve patient outcomes. References: Role of dantrolene in dinitrophenol (DNP) : A continuing question? Am J Emerg Med. 2019 Jun;37(6):1216.e1-1216.e2. https://pubmed.ncbi.nlm.nih.gov/30948257/ 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity . J Med Toxicol. 2011 Sep;7(3):205-12. https://pubmed.ncbi.nlm.nih.gov/21739343/ Ambient temperature and mortality from unintentional . JAMA. 1998 Jun 10;279(22):1795-800. https://pubmed.ncbi.nlm.nih.gov/9628710/ Beware the yellow slimming pill: fatal 2,4-dinitrophenol. BMJ Case Rep. 2016 Apr 4;2016. https://pubmed.ncbi.nlm.nih.gov/27045052/ Dantrolene is not the answer to 2,4-dinitrophenol poisoning: more heated debate. BMJ Case Rep. 2018 Dec 19;11(1):e225323. https://pubmed.ncbi.nlm.nih.gov/30573533/ The effect of 2,4-dinitrophenol on adipose-tissue metabolism. Biochem J. 1969 Feb;111(4):431-44. https://pubmed.ncbi.nlm.nih.gov/4388239/ The mechanism of uncoupling of oxidative phosphorylation by 2,4-dinitrophenol. J Biol Chem. 1967 Oct 25;242(20):4577-83. https://pubmed.ncbi.nlm.nih.gov/4964808/ MECHANISMS OF DINITROPHENOL TOXICITY. Simon E.W. Biological Reviews. Vol 28. (4). Nov 1953. Identification and Importance of Brown Adipose Tissue in Adult Humans. https://www.nejm.org/doi/full/10.1056/NEJMoa0810780 Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev. 2001 Nov;2(4):255-65. https://pubmed.ncbi.nlm.nih.gov/12119996/ LC-MS-MS analysis of 2,4-dinitrophenol and its phase I and II metabolites. J Ana Toxicol. Jan-Feb 2007;31(1):55-61. https://pubmed.ncbi.nlm.nih.gov/17389084/ Uncouplers of oxidative phosphorylation. Environ Health Perspect. 1990 Jul;87:213-8. https://pubmed.ncbi.nlm.nih.gov/2176586/ Texas Woman Charged with Selling Misbranded https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/press-releases/texas-woman-charged-selling-misbranded-drug

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