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Oral GLP-1 agonists—like oral semaglutide—are poised to transform the future of obesity and type 2 diabetes treatment. But how close are we to seeing these medications approved and widely available? In this video, we explore the following: How close are we to oral GLP-1s? Will we ever see ozempic and mounjaro tablets? If so, when? Will Eli Lilly, Novo Nordisk or someone else be first to market? Links: Pfizer’s press release discontinuing research on their candidate molecule: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-provides-update-oral-glp-1-receptor-agonist Eli Lilly’s April press release on Orfoglipron https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-demonstrated-statistically#:~:text=News%20Release-,Lilly's%20oral%20GLP%2D1%2C%20orforglipron%2C%20demonstrated%20statistically%20significant%20efficacy,orforglipron%20worldwide%20without%20supply%20constraints. And their follow-up press release on having these results prublished in the New England Journal of Medicine: https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-showed-compelling-efficacy-and#:~:text=Lilly's%20oral%20GLP%2D1%2C%20orforglipron,Medicine%20%7C%20Eli%20Lilly%20and%20Company NovoNordisk’s progress as of May 2025: https://www.reuters.com/sustainability/boards-policy-regulation/us-fda-accepts-novo-nordisks-application-oral-wegovy-2025-05-02/ Animal study linking *liraglutide* with thyroid cancer, suggesting it may be species-specific https://academic.oup.com/endo/article-abstract/151/4/1473/2456651?redirectedFrom=fulltext&login=false Timestamps: Timeline for getting a new drug to market [00:28] Who is developing oral GLP-1 agonists? [01:22] Eli Lilly - Orforglipron [02:22] Novo Nordisk - Rybelsus (semaglutide) and NN-9932 [04:42] What else is brewing (“The best of the rest”) [06:11] Okay, so you’ve hear a little something about ozempic, wegovy and the gang, a group of utterly revolutionary large molecules that can help aid in really significant weight loss through a series of injections helping to curb appetite and slow gastric emptying, making you feel fuller for longer, wouldn’t it be neat if this came as a tablet? Eli Lilly and Novo Nordisk think so. Eli Lilly, producer of Mounjaro and Zepbound has one drug in Phase III trials, orforglipron, with results coming out from last month and expected to keep rolling in for the rest of the year and the start of next. After which, we may see it launched as an oral medication for both diabetes and weight loss Novonordisk, already has an oral medication FDA approved but only for the management of diabetes, Rybelsus Eli Lilly have over 6,000 people enrolled in ACHIEVE phase 3 trial that is investigating orforglipron as a diabetes medicine and intend to publish the rest of the data in late 2025 and 2026. They are also running their phase 3 trials investigating its efficacy as a weight management drug under the name ATTAIN and expect to submit to the FDA and other global regulatory bodies before the end of 2025, meaning that if the trials continue to come in with positive results and the FDA are happy, Eli Lilly will be bringing an oral weight loss drug to market around the middle of 2026. as for Novo, they’ve been a lot quieter with their press releases of late Rybelsus, its an oral formulation of Novo Nordisk’s semaglutide molecule, which has proven itself effective time and time again in injection form under brands, Ozempic and Wegovy. Its already out there in the US and Europe and works, though the weight loss effects appear to be about half that of Wegovy. clinical studies have found that increasing the dose increases the weight loss achieved, with one 68-week study finding a 50mg daily oral dose led to 15% weight loss, again, linked down below. the best of the rest: On April 14, Pfizer announced the termination of the development of an attempt at an oral obesity medication after the molecule, named danuglipron, was found to damage the livers of a participant of a phase 2 trial. HRS9531, published their phase 2 trial outcomes in June 2024, finding that, in a study of 249 patients a 6.0mg INJECTION lead to an average weightloss of 16% in just 26 weeks in obese, non-diabetic participants. The phase two trial is linked down below https://diabetesjournals.org/diabetes/article/73/Supplement_1/1861-LB/155203/1861-LB-Efficacy-and-Safety-of-HRS9531-a-Novel Both Eli Lilly and Novo Nordisk are near the final hurdle, so, oral weight loss medications of the GLP-1 agonists may be arrive early 2026. ** All the information contained in this video is not intended nor implied to constitute professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general informational purposes only and does not replace a consultation with your own doctor/health professional **

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Country-rap singer Ford, who lost 60 lbs. after a heart attack last year, talked to pal Jelly Roll about his recent weight loss Colt Ford and pal Jelly Roll both hit it big as "big guys." But Ford, the country-rap singer-songwriter who co-wrote Jason Aldean's 2011 hit "Dirt Road Anthem," says when your public image is tied to your size, things can get complicated if you decide to get healthy and slim down. That's what Ford — who once weighed 340 lbs. but who's now down to 290 after a series of health scares — and fellow rapper Jelly Roll, 40, discussed when the two hung out late last year at one of Jelly Roll's concerts. "Jelly has lost a bunch of weight," Ford, 55, says of the rapper's more than 100-lb. slimdown over the past two years. "You start to think when you're a big guy like that and people love you, 'What if I lose weight? Are they going to still like me?' And I'm like, 'No, bro. I thought that for so long. No, no, no. As long as you're who you are, and you're authentic and good to people, sh--, they don't care." Ford's own health journey began in 2022 after he was diagnosed with myasthenia gravis, an autoimmune disease that causes muscle weakness, and then it took on new urgency after he suffered a near-fatal heart attack in April 2024. At the time of his heart attack, Ford had already slimmed to 250 lbs., and since then, he's lost another 60 lbs. by walking more and giving up fried foods and soda. The heart attack was a frightening wake-up call, but, he says, being in a coma for a week and in rehab for nearly months gave him a jump start on getting fit. "There's much easier diets," he jokes. "But when I tried to lose weight before, when you're as heavy as I was...you feel like you're working hard and you still look in the mirror and go, 'This sucks. I'd rather just go back to [fast food chain] Zaxby's.'" But since his health crisis, "I haven't drank a soda," he says. "I drink water and unsweet tea and I'm fine with that. I haven't had fried chicken at all. I'm eating a lot healthier. It's nice to feel good and be able to tell people like Jelly that." Ford, whose first single since his heart attack is out this month ("Hell Out of It"), says he wants to spread the word about healthier living. "I want to advocate all that, get healthier, walk, exercise, just move," he says. "You've got to move your body, whatever it is. If you can't work out every day, walk down the street, walk up and down the stairs at your house, apartment complex, whatever, just any of that sh--makes a difference. That's become a new part of my life now." *** Fair Use Disclaimer: This video is transformative and does not harm or compete with the original works. All content is created for educational or informational purposes. Only limited visual and audio materials are used, strictly when necessary. The purpose of this content is to spread knowledge and raise awareness. Note: This disclaimer is intended to support compliance with content policies and provide context for the material shared.

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