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Learn about the design of a trail-blazing Randomized Controlled Trial (RCT) that will explore the physiology and biology of brain energy metabolism, while also informing clinical applications of ketogenic therapy as an adjunctive treatment option for patients with bipolar and schizophrenia spectrum disorders. RCTs are considered the gold standard when looking at the efficacy and safety of new treatment options. This type of research is necessary to understand whether ketogenic therapy should be offered as a first-line treatment option, as well as what types of strategies could increase accessibility of this intervention in the future. Dr. Bret Scher interviews principal investigators Dost Öngür, MD, PhD, and Dr. Virginie-Anne Chouinard, MD, about the details of this trial at McLean Hospital, a top-rated, Harvard-affiliated psychiatric hospital. Learn more about the impressive design of this trial which includes a multidisciplinary approach to clinical care, gathering a variety of data to inform understanding of underlying brain energy mechanisms (including MRIs and metabolic markers), and an “open-label” approach that will allow the control group to opt into ketogenic therapy at the end of the first trial phase if desired. Dr. Dost Öngür William P. and Henry B. Test Professor of Psychiatry, Chief of the Division of Psychotic Disorders, & Director of the Schizophrenia and Bipolar Disorder Research Program at McLean Hospital https://www.mcleanhospital.org/profile/dost-ongur Dr. Virginie-Anne Chouinard, Staff psychiatrist and Director of Research at McLean OnTrack™ & Instructor in Psychiatry at Harvard Medical School. https://www.mcleanhospital.org/profile/virginie-anne-chouinard Press release about the trial: https://www.prnewswire.com/news-releases/mclean-hospital-launches-clinical-trial-of-ketogenic-therapy-for-bipolar-disorder-302062402.html For information on enrolling: https://clinicaltrials.gov/study/NCT06221852 Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. Timestamps 0:00 Introduction 2:03 Interest leading up to a keto for bipolar study 5:36 Brain energy metabolism and bipolar 7:44 Patient population for the new Harvard study 8:46 About the study 9:21 Dietary studies vs pharmacologic studies 11:55 The different interventions in the keto for bipolar study 14:42 What researchers will be looking at during the clinical trial 17:20 Balancing mechanism and clinical impact in research 19:21 Impact of the clinical trial 21:54 Working with a clinician for ketogenic therapy 25:30 Conclusion #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #BipolarDisorder #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis #MentalIllness #AlternativeTreatment #Obesity #MedicationSideEffects #Schizophrenia #SchizoaffectiveDisorder #SchizophreniaSpectrumDisorders

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The problem with Ozempic is that it works too well for obesity and weight loss. Imagine losing weight simply because you’re not hungry. Imagine suddenly disliking the taste of your favorite, high-calorie foods and preferring healthy, lower-calorie foods instead... because your brain itself has literally been rewired. That’s Ozempic… objectively, it’s… awesome.  As a fitness coach, that may sound irresponsible of me. But if we're going to talk about it, we might as well do so honestly. In this video, I’ll cover everything to know about using Ozempic for weight loss, from how it works to Ozempic’s side effects. Click below to try the BWS+ app for free for 2 weeks, no strings attached: https://builtwithscience.com/ Credit to: Kurzgesagt and Jeff Nippard for the title/thumbnail inspiration Here’s how Ozempic works for weight loss, as explained by Dr. Eric Trexler. It works by mimicking a hormone called GLP-1, which, after we consume food, it tells us, ‘Hey, you're full, and it's time to stop eating.' But it also rewires what your brain actually wants to eat. When you're on ozempic, those same calorie dense, really delicious foods, they just aren't quite as satisfying. What you find is individuals who have less cravings for those high calorie foods and ultimately end up opting for lower calorie foods. Also, according to Dr. Spencer Nadolsky, America’s leading GLP-1 doctor and researcher, Ozempic might have benefits that extend far beyond just weight loss. Research found in those with a history of heart disease and obesity, it reduced more heart attacks than a placebo. People thought that it would be from the weight loss that you get from it, but they're actually these GLP-1 receptors all over the body and including the heart that it's thought that these drugs help reduce a lot of this risk of stuff through. But to be completely transparent with you, Dr. Spencer isn’t just familiar with the research on Ozempic, he prescribes it regularly. So if we’re going to be honest about its benefits, we should also be honest about Ozempic’s side effects.  The first is “Ozempic face” and “Ozempic butt”. So when you lose a lot of weight, you’ll see that “sucked-in” look. These side effects are made even more visible when you combine muscle loss into the equation. On Ozempic, you still might struggle to eat anything at all. What do you think happens to your muscle? Your body quickly starts breaking it down. Then, stack that on top of the other big problem: low energy. Because overeating becomes more difficult, Ozempic can unintentionally put you in a severe calorie deficit.  As a result, your workouts suffer. Another alarming, potential side effect is blindness. What happens to your body, and brain, when you stop taking Ozempic? Ozempic removes the part of “you” that makes you overweight. But when you go off it, your old self is back. That’s why on average, after hopping off drugs like Ozempic, most people regain 2/3rd’s of the weight they lost within the first year. And this is why most patients end up staying on the drug indefinitely. So many people, especially in the fitness industry, are against the idea of Ozempic. Ozempic gets you results without the suffering. It is kind of like... “cheating.” I without a doubt would have felt this way about Ozempic back when I was younger. But now, I understand something I didn’t back then. Many people who are obese or overweight WANT to change. Yes, obesity can be environmental, but obesity can also be, in many cases, genetic. So if you’re overweight and meet the criteria, Ozempic is a game changer. But what if… You’re healthy and just want to take ozempic to get leaner? The drug seems to be slowly making its way to the bodybuilding community. Is this bordering the line of abuse? Arguably, yes. But what we define as “abuse” of the drug I predict will very quickly change. It started as a treatment for diabetes. And now it's being used for weight loss.  In the future, I believe Ozempic, and a handful of drugs like it, will be used by many people. Because Ozempic is a very special weight-loss drug that causes you to lose weight better than anything else out there, and, for now, doesn’t seem to be dangerous to your health, and if anything, will improve it. Assuming you qualify for it, there is only one objective reason to not take ozempic right now. Cost. It’s expensive. But the primary patent protecting ozempic in the United States is expected to expire in December 2031. Shortly after that, I predict we’ll not only start seeing cheaper Ozempic generics hit the market, but more effective ones. I also predict the rules to qualify for the drug will be far more relaxed. And when that happens…. Who knows. Maybe Ozempic will become the new multivitamin. Maybe America will finally reverse its obesity epidemic and drop its average BMI back down to the global average.  Click below to subscribe for more videos: https://www.youtube.com/jeremyethier/?sub_confirmation=1

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Lizzo is celebrating her journey with unapologetic confidence! The 36-year-old superstar shared a striking Instagram carousel featuring her Yitty lingerie, a midriff-baring mirror selfie, and a nod to Severance memes—all while subtly showcasing her weight loss. Dive into the details of her empowering post, her recent clash with Andy Cohen, and how she’s owning her narrative. 💬 “Self-love looks GOOD on her!” — Share your thoughts below! Like, comment, and subscribe for more updates on Lizzo’s journey and celebrity empowerment stories. #Lizzo #BodyPositivity #Yitty #WeightLossJourney #InstagramVibes #Severance #CelebrityConfidence #MusicNews #SelfLove #AndyCohen

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