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Welcome to my channel. Today, we'll discuss GLP-1 | A New Era in Obesity Treatment. GLP-1 (glucagon-like peptide-1) receptor agonists were originally developed to treat type 2 diabetes. However, researchers soon discovered a notable side effect: significant weight loss. This revelation has reshaped obesity treatment, offering new hope to millions struggling with weight management. ----------------------------------------------------------------- ►Like Facebook Page: https://www.facebook.com/drsamrph ►Like Twitter Page: https://twitter.com/zeal_nutri ►Follow at Instagram: https://www.instagram.com/zealnutri123 Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statutes that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use.
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Click Here to Subscribe: http://Bit.ly/ThomasVid Get MY Groceries at MY Price with Thrive Market: http://ThriveMarket.com/Thomas My Website: http://ThomasDeLauer.com Snacking vs. Fat Loss | The Dangers of Snacking Between Meals | Insulin Spiking- Thomas DeLauer… Snacking - Insulin & Glucagon: Whenever you eat food, your pancreas releases insulin into the blood - as the nutrients are slowly absorbed into cells, insulin levels drop, until finally all the nutrients are absorbed, and insulin levels then remain steady at a low, “baseline” level. So, when you're constantly eating, you're consistently releasing insulin, which puts your body into its "absorptive phase." This means that the insulin in your body is storing sugar and not letting other enzymes in your body release sugar to break down fat. Glucagon: Insulin, the fat-storage and blocking hormone, has a counterpart known as glucagon – a fat-burning and unlocking hormone. About four to six hours after you eat, the glucose levels in your blood decrease, triggering your pancreas to produce glucagon. This hormone signals your liver and muscle cells to change the stored glycogen back into glucose. Glucagon signals the fat cells to release free fatty acids (a process called lipolysis), which signals the body to release stored fat to be used as fuel. Snacking & Digestion: Snacking can affect digestive function as it may increase risk for developing bacterial overgrowth. When bacteria replicate excessively in the small intestine, it results in a condition called Small Intestinal Bacterial Overgrowth. When the body is fasted, the muscles in the small intestine produce a periodic wave of forward motion called the migrating motor complex. The migrating motor complex is a distinct pattern of electromechanical activity observed in gastrointestinal smooth muscle during the periods between meals. It is thought to serve a "housekeeping" role and sweep residual undigested material through the digestive tube. The intestines need to be fasted for at least 90 minutes at a time in order for routine cleansing waves to occur. An increase in gastric, biliary and pancreatic secretion is also seen in conjunction with the motor activity. These secretions aid in the cleansing activity of the migrating motor complex and assist in preventing a buildup of bacterial populations in the proximal segments of the digestive tube. Study - 2 Meals vs 6 Meals per Day: Published in the journal Diabetologica, researchers found that eating 2 larger meals a day (breakfast and lunch) is more effective than 6 smaller meals in a reduced-energy regimen (for patients with type 2 diabetes.) The study compared the effect of six (A6 regimen) vs two meals a day, breakfast and lunch (B2 regimen), on body weight, hepatic fat content (HFC), insulin resistance and beta cell function. Design: Researchers assigned 54 patients with type 2 diabetes, both men and women, age 30–70 years, to follow two regimens of a hypoenergetic diet (below normal, caloric restriction), A6 and B2, each for 12 weeks. The diet in both regimens had the same macronutrient and energy content. Results: Body weight decreased in both regimens, more for B2 (-5.07 lbs for A6 vs −8.1 lbs for B2) HFC decreased in response to both regimens, more for B2 (−0.03% for A6 vs −0.04% for B2) Fasting plasma glucose and C-peptide levels decreased in both regimens, more for B2 Fasting plasma glucagon decreased with the B2 regimen, whereas it increased for the A6 regimen OGIS (oral glucose insulin sensitivity) increased in both regimens, more for B2 - No adverse events were observed for either regimen. Conclusion: Eating only breakfast and lunch reduced body weight, HFC, fasting plasma glucose, C-peptide and glucagon, and increased OGIS, more than the same caloric restriction split into six meals. References: 1) How Insulin Really Works: It Causes Fat Storage...But Doesn't Make You Fat | Muscle For Life. (n.d.). Retrieved from https://www.muscleforlife.com/how-insulin-works/ 2) Understanding Our Bodies: Insulin | Nutrition Wonderland. (n.d.). Retrieved from http://nutritionwonderland.com/2010/05/understanding-our-bodies-insulin/ 3) Insulin and Glucagon: How Do They Work? (n.d.). Retrieved from http://www.healthline.com/health/diabetes/insulin-and-glucagon#Workingtogether2 4) Unlock Glucagon: Your Body's Fat-Burning Hormone. (n.d.). Retrieved from http://healinggourmet.com/weight-loss-diet/unlock-glucagon-fat-burning-hormone/ 5) The effect of meal frequency in a reduced-energy regimen on the gastrointestinal and appetite hormones in patients with type 2 diabetes: A randomised crossover study. (n.d.). Retrieved from http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174820 6) The Migrating Motor Complex. (n.d.). Retrieved from http://www.vivo.colostate.edu/hbooks/pathphys/digestion/stomach/mmcomplex.html
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