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Click Here to Subscribe: http://Bit.ly/ThomasVid Website: http://ThomasDeLauer.com Massive Discount on Locally Sourced Grassfed Beef Right to Your Door: https://www.farmfoodsmarket.com/discount/THOMAS2018 How Fasting Burns Fat: Activate Fat Burning Enzymes- Thomas DeLauer… Norepinephrine and Epinephrine: Adrenaline is released from the adrenal cortex & goes through the bloodstream to affect numerous tissues in the body. Noradrenaline is released from the nerve terminals and is the main neurotransmitter of the sympathetic nerves in the cardiovascular system. These two play a primary role in the breakdown of fat by binding to the beta-1 and 2 receptors in the body, which increases cAMP levels which in turn increases fat breakdown. The nervous system sends norepinephrine to the fat cells, making them break down body fat into free fatty acids that can be burned for energy (1,2) Hormone Sensitive Lipase: Fasting increases the activation of hormone sensitive lipase Activating hormone sensitive lipase initiates lipolysis, the breaking down of triacylglycerols into free fatty acids and glycerol (3) Glucagon: Fasting also increases glucagon levels, which breaks down fat - glucagon is a hormone that acts directly opposite to insulin (the pancreas secretes it in an effort to raise blood sugar levels) While insulin stores carbs and builds fat, glucagon is responsible for breaking down stored carbs and fats and releasing them so your body can use them for energy (4) How They All Work Together: The only site for regulation of fatty acid oxidation is at the level of hormone-sensitive lipase in adipose tissue. Under fasting conditions, with minimal insulin in the blood, glucagon promotes formation of the active form of hormone-sensitive lipase. When epinephrine is present, it further actives hormone-sensitive lipase, increasing the hydrolysis of triglycerides to produce free fatty acids (FFA) and glycerol. The glycerol is carried to the liver, where it enters gluconeogenesis, while the FFA are carried on serum albumin to the tissues where they are catabolized for energy. The liver uses some of the energy from fat mobilization to support gluconeogenesis (5) Additional: Ketone Production: Burn Fat Instead of Sugar- Fasting shifts your metabolism from burning sugar to burning fat - begins to break down triglycerides in the form of ketones. References: 1) Zauner C , et al. (n.d.). Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/10837292 2) Jensen MD , et al. (n.d.). Lipolysis during fasting. Decreased suppression by insulin and increased stimulation by epinephrine. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/3540009 3) Sztalryd C and Kraemer FB. (n.d.). Regulation of hormone-sensitive lipase during fasting. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/8141275 4) Marliss EB , et al. (n.d.). Glucagon levels and metabolic effects in fasting man. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/5480852 5) Hormone-sensitive lipase - an overview | ScienceDirect Topics. (n.d.). Retrieved from https://www.sciencedirect.com/topics/neuroscience/hormone-sensitive-lipase 6) Adrenalin and Noradrenalin The 'Dynamic Duo? (2015, April 9). Retrieved from https://thefatlossmanifesto.com/adrenalin-and-noradrenalin-the-dynamic-duo/

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Prescribing Semaglutide for weight loss has been a hot topic in the medical world recently. Semaglutide is a medication traditionally used to treat type 2 diabetes, but studies have shown that it can also be effective in helping patients lose weight. As doctors consider prescribing Semaglutide for weight loss, there are several factors they must take into account to ensure the safety and effectiveness of this treatment.

Effectiveness of Semaglutide for Weight Loss

Semaglutide works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) that is naturally produced in the body. This hormone helps regulate hunger and food intake, making Semaglutide an effective weight loss aid. Clinical trials have shown that patients who take Semaglutide in conjunction with a reduced-calorie diet and increased physical activity experience significant weight loss compared to those who do not take the medication.

However, it is important to note that Semaglutide is not a miracle drug – it is most effective when used as part of a comprehensive weight loss plan that includes healthy eating and exercise. Patients who take Semaglutide must be committed to making lifestyle changes in order to see the best results.

Additionally, not all patients will respond the same way to Semaglutide treatment. Doctors must carefully consider each patient’s individual health history, medical conditions, and weight loss goals before prescribing this medication.

Potential Side Effects and Risks

As with any medication, Semaglutide comes with potential side effects and risks. The most common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects typically subside over time as the body adjusts to the medication, but some patients may find them intolerable.

In rare cases, Semaglutide can also cause more serious side effects such as pancreatitis, gallbladder problems, and kidney issues. Patients with a history of these conditions may not be good candidates for Semaglutide treatment, and doctors must weigh the risks and benefits carefully before prescribing this medication.

It is important for doctors to monitor patients closely while they are taking Semaglutide to ensure that any potential side effects are caught early and managed appropriately. Patients should also be educated about the signs and symptoms of serious side effects so they can seek medical attention if necessary.

Long-Term Effects and Considerations

One of the biggest concerns when prescribing Semaglutide for weight loss is the long-term effects of the medication. While clinical trials have shown promising results in the short term, the safety and effectiveness of Semaglutide for long-term weight management are still being studied.

Doctors must consider the potential risks of long-term Semaglutide use, such as nutrient deficiencies, changes in gut hormone levels, and the development of drug resistance. It is important for patients to have regular follow-up appointments with their doctors while taking Semaglutide to monitor for any long-term effects and adjust treatment as needed.

Ultimately, the decision to prescribe Semaglutide for weight loss should be made on a case-by-case basis, taking into account each patient’s individual health needs and goals. While Semaglutide can be a helpful tool in the fight against obesity, it is not a one-size-fits-all solution and should be used carefully and judiciously.

Patient Education and Support

Another important factor for doctors to consider when prescribing Semaglutide for weight loss is patient education and support. Patients must be fully informed about the risks and benefits of Semaglutide treatment, as well as what to expect while taking the medication.

Doctors should also provide patients with resources and support to help them make healthy lifestyle changes and stick to their weight loss goals. This may include referrals to dietitians, exercise physiologists, or behavioral therapists who can help patients develop sustainable habits for long-term weight management.

By taking a holistic approach to weight loss that includes both medication and lifestyle changes, doctors can help patients achieve lasting results and improve their overall health and well-being.

Conclusion

Prescribing Semaglutide for weight loss is a decision that doctors must make carefully, taking into account the effectiveness of the medication, potential side effects and risks, long-term considerations, and patient education and support. While Semaglutide can be a valuable tool in helping patients achieve their weight loss goals, it is not a one-size-fits-all solution and should be used judiciously in conjunction with a comprehensive weight loss plan. By considering all of these factors, doctors can help their patients safely and effectively lose weight and improve their overall health.

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