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Weight loss drugs have become an increasingly popular, but controversial, way of quickly shedding extra pounds over the past few years. Part of that controversy deals with the side effects caused by some of the more well-known medications like Ozempic and Mounjaro. According to the Obesity Medicine Association (OMA), researchers are continually analyzing the pros and cons of these drugs. Here are some side effects of the eight FDA-approved weight loss drugs: Ozempic and Wegovy Ozempic and Wegovy are the brand names of a drug known as semaglutide, a medication that, according to Harvard Health, has been prescribed for about two decades to treat Type 2 diabetes. Ozempic has become controversial over the past few years as overweight and obese patients have sought it out for weight loss, creating a shortage of the drug for those using it to control their diabetes. Wegovy is the brand name for a form of semaglutide that has since been approved for weight loss. Semaglutide, which mimics a natural hormone called GLP-1, helps regulate blood sugar while slowing down the emptying of the stomach and signaling satiety or fullness to the brain. The OMA reports that the most common complaint among patients using semaglutide is gastrointestinal issues like nausea. Other side effects include fatigue, dizziness, headache, bloating, belching and heartburn.An American Medical Association study has also found that GLP-1 agonists are associated with an increased risk of pancreatitis, bowel obstruction, and gastroparesis. While headlines have warned about an increase in suicidal ideation with semaglutide, a January 2024 study in Nature Medicine suggested “a 49% to 73% lower risk of first-time or recurring suicidal ideations” compared with other obesity medications. Mounjaro and Zepbound Mounjaro and Zepbound are drugs known as tirzepatide. Mounjaro was approved in 2017 to treat Type 2 diabetes, while Zepbound was approved in more recent years to treat obesity. Like semaglutide, tirzepatide is a GLP-1 agonist that increases a person’s feeling of fullness and helps them maintain a weight loss diet. It causes common mild symptoms like nausea, constipation, diarrhea and bloating, but the OMA reports more serious side effects like kidney problems up to and including kidney failure, gallbladder symptoms, pancreatitis and hypoglycemia. Manufacturer Eli Lilly warns, however, that Tirzepatide may cause thyroid tumors or thyroid cancer. Patients should monitor themselves for symptoms like neck swelling, hoarseness, problems swallowing and shortness of breath. Contrave Contrave is the brand name for a medication that combines two drugs, bupropion and naltrexone. Bupropion, which is marketed under the brand name Wellbutrin, is an antidepressant that is also known to reduce a person’s appetite. Naltrexone, commonly sold under the brand names Revia and Vivitrol, is a medication used to treat drug and alcohol addiction. According to Drugs.com, naltrexone works by blocking the euphoric, intoxicated feeling of alcohol and opioids. It also helps reduce the cravings for the substances. The OMA reports that patients should not be prescribed Contrave if they suffer from a seizure disorder or if they take opioids for chronic pain. The most common side effects of the drug are nausea, vomiting, constipation, diarrhea, headache, dizziness, dry mouth and insomnia. Saxenda Saxenda is a medication containing liraglutide, a drug that mimics a person’s natural hormones affecting hunger, digestion and feelings of fullness. It was approved by the FDA in 2017 to treat obesity in people 12 and older. The most common side effects of liraglutide are nausea, vomiting, constipation, diarrhea, headache, fatigue, dyspepsia, dizziness and abdominal pain. It can also cause increased heart rate, increased lipase, which is a pancreatic enzyme, and decreased kidney function. Qsymia Qsymia is a medication that combines the drugs phentermine and topiramate. According to the OMA, phentermine has been around since 1959, making it the oldest and most widely used weight loss medication. The drug, which works in the brain as an appetite suppressant, is a stimulant similar to amphetamines and can be abused. It should not be used by patients who have suffered a stroke or who have heart disease, glaucoma or hyperthyroidism. The side effects of phentermine can be serious, including fast or irregular heart rate, headache, overstimulation, high blood pressure and tremors. It can also interact with several other drugs, including MAO inhibitors, alcohol, adrenergic neuron blockers and some anesthetic agents. When phentermine is combined with topiramate, an anticonvulsant, its effect on hunger is magnified. The side effects of the two drugs combined include dizziness, abnormal sensations, altered taste, insomnia, constipation and dry mouth. Topiramate also carries a risk of birth defects, so it should not be taken during pregnancy.
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Trisha’s weight loss journey had been a struggle for years. She had tried numerous diets, exercise plans, and supplements without much success. That was until she discovered a new product that changed everything – weight loss gummies. These gummies were unlike anything she had ever tried before, and they quickly became a game-changer in her weight loss journey.
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Trisha was curious about how these gummies were able to produce such impressive results. After doing some research, she learned that the key ingredients in the gummies were natural fat-burning compounds like green tea extract, Garcinia Cambogia, and apple cider vinegar. These ingredients worked together to boost metabolism, suppress appetite, and increase fat burning in the body.
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Trisha’s friends and family were amazed by her transformation and were eager to learn more about the gummies that had made such a difference in her life. She happily shared her secret with them, knowing that she was helping others on their own weight loss journeys.
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#glp1 #obesity #weightmanagement In late 2024 I spoke with an academically trained cardiologist expert in cardiometabolic risk prevention and obesity medicine, educator, Dr. Eldad Einav, from Beverly Hills, CA about the ongoing controversy about the shortage and patient access to the exciting new weight loss treatments such as GLP1 agonists. He shared many practical, clinical insights and research that are important to revisit today for patients, physicians, and payers who are seeking to provide the best solutions and learn from some recent shortcomings. 0:00 Highlight #1 - Distinguishing the quality of weight loss solutions 1:26 Highlight #2 - Providing reliable 503B Facility source for patients w/ no access to GLP1 3:18 - Speaker Introduction 6:14 - Why Dr. Einav decided to specialize in obesity / weight loss 9:38 - Why should cardiologists focus on weight management - preventive care? 11:58 - Not many cardiologists manage weight 12:34 - Patient preferences to treat weight vs hypertension or cholesterol 14:34 - Problem of maintaining long-term weight loss 15:00 Look AHEAD study - well-controlled lifestyle study of weight loss with 16:19 Drugs meeting newer targets of 15% or higher weight loss 16:57 - Select Trial: weight loss reduces risk of heart attack, stroke by 20% 19:07 - New drugs approaching efficacy of bariatric surgery 21:29 - 2024 Shortage and patient access to new GLP1 drugs 23:11 - Specialty pharmacy compounding GLP controversy 26:06 - What doctors should know about choosing compounded drug alternatives 27:54 - What patients should know about choosing their weight loss drugs 31:22 - Reality of types of compounded medications used by US hospitals 32:11 - Removing the double-standard of compounded medications to improve patient access 33:46 - Helpful resources to learn how to access the right weight-loss medication 37:47 - Advice to Patients & HCPs to improve access and consolidate care
