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How much protein do you need? Anywhere from 10% to 35% of your calories should come from protein. So if your needs are 2,000 calories, that's 200–700 calories from protein, or 50–175 grams. The recommended dietary allowance to prevent deficiency for an average sedentary adult is 0.8 grams per kilogram of body weight. The exact amount of protein you need depends on many factors, including activity level, age, muscle mass, and overall health. Few nutrients are as important as protein. Not getting enough of it will affect your health and body composition. However, opinions regarding how much protein you need vary. Most official nutritional organizations recommend a fairly modest protein intake. The DRI (Dietary Reference Intake) is 0.36 grams of protein per pound (0.8 grams per kg) of body weight. This amounts to 54 grams per day for an 150 pound sedentary person or 65 grams per day for an 180 pound sedentary person: This may be enough to prevent deficiency, but the amount you need depends on many factors, including your activity level, age, muscle mass, physique goals, and overall health. This article examines the optimal amounts of protein and how lifestyle factors like weight loss, muscle building, and activity levels factor in. What is protein, and why is it important? Protein is essential to good health. The very origin of the word — from the Greek protos, meaning "first" — reflects protein’s top-shelf status in human nutrition. You need it to put meat on your bones and to make hair, blood, connective tissue, antibodies, enzymes, and more. It’s common for athletes and bodybuilders to wolf down extra protein to bulk up. But the message the rest of us often get is that our daily protein intake is too high. The Recommended Dietary Allowance (RDA) for protein is a modest 0.8 grams of protein per kilogram of body weight. The RDA is the amount of a nutrient you need to meet your basic nutritional requirements. In a sense, it’s the minimum amount you need to keep from getting sick — not the specific amount you are supposed to eat every day. To determine your daily protein intake, you can multiply your weight in pounds by 0.36, or use this online protein calculator. For a 50-year-old woman who weighs 140 pounds woman and who is sedentary (doesn’t exercise), that translates into 53 grams of protein a day. Protein: Is more better? For a relatively active adult, a daily protein intake to meet the RDA would supply as little as 10% of his or her total daily calories. In comparison, the average American consumes around 16% of his or her daily calories in the form of protein, from both plant and animal sources. But is that too much? For some people, there may be potential benefits of higher daily protein intake to preserve muscle mass and strength. How and when you consume protein might also influence its effectiveness. Some studies described in the summit reports suggest that protein is more effective if you space it out over the day’s meals and snacks, rather than loading up at dinner like many Americans do. On a biological level, proteins are sort of like Legos for our bodies. They’re the building blocks that make up our organs, tendons, hormones and, of course, muscles. But it’s that last thing on the list that gets so much attention when it comes to protein intake and exercise. All over your local gym, you’ve probably seen your fair share of protein shakes. It’s synonymous with muscle gain and weight loss, but can you overdo it? Let’s take a look and find out. How much protein should I be consuming? According to the Dietary Reference Intake report for macronutrients, a sedentary adult should consume 0.8 grams of protein per kilogram of body weight, or 0.36 grams per pound. That means that the average sedentary man should eat about 56 grams of protein per day, and the average woman should eat about 46 grams. Can I eat an all-protein diet? Yes, technically you could. But it wouldn’t be good for you. (We’ll explore that more in a moment.) But basically, you should aim for anywhere between 10%-35% of your calories coming from protein. So if your body requires 2,000 calories per day, 200-700 calories should come from protein. How do exercise and dieting affect protein intake? The short answer is the more you exercise and burn calories, the more protein you can healthily eat. In fact, protein is great for weight loss because protein-rich foods leave you feeling much more full than fat and carbs. But all things in moderation — you can still gain weight when overeating protein, just like any other food. Remember to focus on calories in versus calories out — your body will only process or convert a certain percent of what you eat into energy.

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We were honored to host Professor Robert Lustig, MD, at Emery Pharma once again. Dr. Lustig, a renowned Pediatric Endocrinologist from UCSF, delivered an insightful presentation on the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and its critical links to metabolic dysfunction. Below are the key highlights from his talk: Non-Alcoholic Fatty Liver Disease (NAFLD) Overview NAFLD impacts 45% of Americans and 25% of the global population, often going undetected until complications arise. Once primarily associated with alcohol use, NAFLD is now prevalent in children, largely due to dietary factors like sugar consumption. Key Points from Dr. Lustig's Talk Core Arguments Fat and Metabolic Disease: Obesity is a risk factor but not the direct cause of metabolic diseases like type 2 diabetes and NAFLD. Internal fat distribution (e.g., visceral and liver fat) rather than subcutaneous fat plays a critical role, even in individuals with normal BMI. Fructose as a Toxin: Fructose, found in sugar and processed foods, overwhelms liver mitochondria, driving fat production (de novo lipogenesis). The liver damage caused by fructose is similar to that caused by alcohol, though without affecting the brain. Inflammation and Oxidative Stress: Fructose accelerates oxidative stress and inflammation, contributing to liver fat accumulation, insulin resistance, and type 2 diabetes. Three-Hit Hypothesis: NAFLD arises from three factors: Mitochondrial dysfunction causing fat buildup. Reactive oxygen species (ROS) leading to inflammation. Malnutrition impairing the liver's ability to export fat. Interventions: Addressing dietary quality, particularly by reducing sugar intake, is more effective than focusing solely on weight loss. While exercise and balanced nutrition help, drugs targeting NAFLD are still experimental. Key Data Points Children and NAFLD: 25% of children with type 2 diabetes have a normal BMI, underscoring the impact of diet over obesity alone. Fructose Restriction Study: Replacing fructose with glucose in obese children significantly reduced liver fat and metabolic syndrome markers without weight loss. Comparison to Alcohol: Fructose causes liver damage through similar pathways as alcohol, though it does not affect the brain. Call to Action Dr. Lustig urged for a shift toward reducing sugar consumption as a public health priority, emphasizing that fixing the food supply and curbing processed food consumption is critical to tackling metabolic diseases. Q&A Highlights Dr. Lustig discussed the limitations of GLP-1 agonists, noting their high cost, limited access, and failure to address the root causes of metabolic dysfunction. He reinforced that dietary quality, particularly reducing fructose and processed foods, plays a more significant role in combating these conditions than fat content. Closing Remarks Dr. Lustig emphasized the urgent need for systemic changes in food policies to prevent diseases associated with poor nutrition. He advocated for education and significant reductions in sugar intake as primary strategies to improve public health. To watch the full video of Dr. Lustig’s presentation, click here: https://youtu.be/oIWRmOIR_CM. To access the curated playlist of all Professor Lustig’s talks at Emery Pharma, click here: https://www.youtube.com/playlist?list=PLlTSLi3qD78edU0aWyV8x9yLMIS-FC2fv.

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