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Learn more about becoming an Insider: https://www.benbikman.com Dr. Bikman’s Metabolic Classroom lecture this week explores the physiological role and implications of GLP-1 (glucagon-like peptide-1) and the GLP-1 receptor agonist drugs used for type 2 diabetes management and weight loss. Ben begins by explaining GLP-1 as a hormone produced in the intestines in response to food. It plays a vital role in slowing gastric emptying, suppressing glucagon, and regulating appetite by signaling fullness to the brain. These mechanisms contribute to its effects on stabilizing blood sugar and enhancing insulin sensitivity. He then delves into GLP-1 receptor agonists, drugs that mimic GLP-1’s actions, including semaglutide, liraglutide, and others marketed under brand names like Ozempic and Wegovy. These medications have gained fame for their weight loss efficacy, often leading to reductions in body weight by 15% or more. However, Ben emphasizes that weight loss involves not only fat but also lean mass, raising concerns about muscle loss and metabolic health. Additionally, he discusses the medications’ side effects, including depression, anhedonia, and potential long-term complications like fat cell development and gallstones. The lecture also addresses the diminishing returns of these drugs over time, noting that their efficacy in reducing cravings and improving eating control tends to wane after prolonged use. Dr. Bikman highlights that education on healthy eating and resistance training is crucial for maintaining health outcomes, as reliance solely on medication can lead to unintended consequences, such as increased fat regain after discontinuation. Ben concludes by stressing the importance of combining these drugs with a low-carb diet and resistance training to minimize muscle loss and optimize long-term outcomes. He encourages using the lowest effective dose and underscores the need for lifestyle changes to complement pharmacological interventions. Show Notes/References: For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more about becoming an Insider on our website: https://www.benbikman.com (Auto-Translate Note: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) #GLP1 #WeightLossDrugs #Ozempic #Wegovy #Semaglutide #Liraglutide #Type2Diabetes #DiabetesManagement #InsulinResistance #WeightLossTips #MetabolicHealth #DrBenBikman #MetabolicScience #MuscleHealth #MentalHealthMatters #LowCarbDiet #FatLoss #HealthRisks #DiabetesDrugs #ScienceExplained Timestamps: 00:01 - Introduction and Overview 02:16 - What is GLP-1? 03:15 - GLP-1's Role in Metabolism 05:08 - Appetite Regulation and Insulin Effects 07:05 - GLP-1 and Blood Sugar Management 08:10 - Introduction to GLP-1 Receptor Agonists 09:05 - Key GLP-1 Drugs and Brand Names 12:04 - Weight Loss Mechanisms of GLP-1 Drugs 14:06 - Mental Health Risks of GLP-1 Drugs 16:15 - Muscle Loss Concerns 18:24 - Fat Cell Differentiation and Regain Risk 20:07 - Long-Term Diminishing Effects 25:30 - Pancreatitis and Gallstones 29:11 - Closing Thoughts and Recommendations Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: Ben10) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd Learn more about becoming an Insider on our website: https://www.benbikman.com

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00:00 - Intro 00:25 - Exploring the Genetic Link Between GLP-1 Medicines and Pancreatitis Risk 06:21 - Deadly Side Effects of Weight-Loss Drugs: New Investigation Reveals Risks 09:32 - Mounjaro Warning: The Common Mistake Putting You at Risk of Deadly Organ Damage 17:08 - Ozempic & GLP-1 Drugs: New Investigation Reveals Potentially Deadly Side Effects 1. Exploring the Genetic Link Between GLP-1 Medicines and Pancreatitis Risk In this video, we delve into the recent investigation by the MHRA and Genomics England regarding the potential genetic factors influencing the risk of acute pancreatitis in patients using GLP-1 receptor agonists. Learn about the Yellow Card scheme, the importance of reporting side effects, and how genetic testing could revolutionize personalized medicine. We also discuss the implications for healthcare professionals and patients alike. Stay informed about the latest developments in drug safety and patient care. 2. Deadly Side Effects of Weight-Loss Drugs: New Investigation Reveals Risks GLP-1 drugs like Ozempic and Wegovy have revolutionized weight loss, but they come with serious risks. A new UK investigation highlights potentially fatal side effects, including acute pancreatitis, linked to these medications. Learn about the alarming reports, symptoms to watch for, and what experts say about genetic screening to reduce risks. Stay informed about the latest findings and safety warnings from regulators. Keywords: weight-loss drugs, Ozempic side effects, Wegovy risks, GLP-1 drugs, acute pancreatitis, weight-loss drug dangers, UK investigation, FDA warnings, semaglutide risks, Mounjaro safety. 3. Mounjaro Warning: The Common Mistake Putting You at Risk of Deadly Organ Damage A critical warning for anyone using or considering the Mounjaro weight loss injection. A common oversight by some GPs could be putting patients at risk of severe, and even deadly, organ damage. In this video, we break down the urgent warning from health expert Rachael Joy, a nurse and chief clinical officer at SheMed. She explains why a simple, mandatory blood test is essential before starting Mounjaro. This vital screening can identify underlying health issues that could make the treatment dangerous. Learn about the serious risks associated with skipping this test, including: - Pancreatitis: A life-threatening inflammation of the pancreas linked to high triglyceride levels. - Organ Failure: How severe pancreatitis can lead to sepsis and the failure of major organs like the kidneys and lungs. - Severe Dehydration: A particular risk for people with uncontrolled diabetes, which can lead to seizures and kidney failure. We also cover the ongoing investigation by the UK's MHRA into GLP-1 injections (like Mounjaro, Ozempic, and Wegovy) after hundreds of users developed pancreatitis. Find out what symptoms to watch for and how genetic testing may make these drugs safer in the future. This information is crucial for patient safety. If you are using a weight loss jab, ensure you understand the risks and have had the proper medical screenings. Disclaimer: This video is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional regarding your health and before starting any new treatment. 4. Ozempic & GLP-1 Drugs: New Investigation Reveals Potentially Deadly Side Effects Are weight loss drugs like Ozempic and other GLP-1s safe? A new investigation reveals potentially deadly side effects. A UK regulator, the MHRA, has received nearly 400 reports of serious pancreas problems (pancreatitis) linked to these popular weight loss and diabetes medications. Tragically, at least 10 deaths in the UK are now associated with these complications. Learn about the risks, the ongoing investigation, and how genetic testing might play a role in preventing these serious side effects reported by users.

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